INT93387

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 30
Disease Relevance 2.58
Pain Relevance 5.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular amino acid metabolic process (Sds)
cytoplasm (Sds)
Anatomy Link Frequency
neurons 14
neuronal 1
spinal cord 1
brainstem 1
midbrain 1
Sds (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 505 100.00 Very High Very High Very High
GABAergic 21 100.00 Very High Very High Very High
spinal dorsal horn 5 100.00 Very High Very High Very High
Cannabinoid 399 99.76 Very High Very High Very High
analgesia 42 99.64 Very High Very High Very High
projection neuron 21 99.40 Very High Very High Very High
medulla 42 99.16 Very High Very High Very High
Spinal cord 486 99.08 Very High Very High Very High
midbrain 21 98.60 Very High Very High Very High
Cannabinoid receptor 189 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lung Cancer 3 98.60 Very High Very High Very High
Cognitive Disorder 10 96.80 Very High Very High Very High
Urological Neuroanatomy 21 96.48 Very High Very High Very High
Targeted Disruption 22 95.68 Very High Very High Very High
Pain 64 95.36 Very High Very High Very High
Nociception 86 95.24 Very High Very High Very High
Body Weight 2 94.28 High High
Toxicity 1 92.12 High High
Generalized Anxiety Disorder 3 91.12 High High
Pruritus 21 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevations in mitochondrial LPO along with decrements in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, vitamin E and vitamin A), citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (alpha-KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and respiratory chain enzymes (NADH dehydrogenase and Cytochrome c oxidase) were observed in B(a)P (50mg/kg body weight) administered animals.
Gene_expression (Elevations) of SDH in respiratory associated with body weight
1) Confidence 0.65 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18023135 Disease Relevance 0.35 Pain Relevance 0.16
Figure 2 and Table 1 compare the properties of GlyR-mediated mIPSCs recorded in SDH and DDH neurons.
Gene_expression (neurons) of SDH in neurons
2) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.14
Thus, future experiments are needed to determine why the kinetics of GlyR channels in the SDH and DDH differ.
Gene_expression (channels) of SDH
3) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.08 Pain Relevance 0.19
Interestingly, the slower decay times of GABAA-mediated mIPSCs in the SDH resulted in a significantly greater charge transfer per mIPSC in SDH versus DDH neurons (717.3 ± 75.5 vs. 486.3 ± 52.4 pA.ms).
Gene_expression (transfer) of SDH in neurons
4) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0
Many of the properties of GABAAR-mediated mIPSCs were similar in SDH and DDH neurons (Table 1, Figure 3).
Gene_expression (neurons) of SDH in neurons
5) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.06
In addition, we observed a significant effect of methAEA on GABAAR-mediated mIPSC rise time, however, this was confined to SDH neurons.
Gene_expression (neurons) of SDH in neurons
6) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.05 Pain Relevance 0.33
In both SDH and DDH neurons, GlyR- and GABAAR-mediated mIPSCs were best fit by a single decay time constant [39].


Gene_expression (neurons) of SDH in neurons
7) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.03
Interestingly, the slower decay times of GABAA-mediated mIPSCs in the SDH resulted in a significantly greater charge transfer per mIPSC in SDH versus DDH neurons (717.3 ± 75.5 vs. 486.3 ± 52.4 pA.ms).
Gene_expression (neurons) of SDH in neurons
8) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0
This can not explain the slower kinetics of SDH mIPSCs, as developmental studies in spinal cord [55] and brainstem neurons [39,53] show GlyRs containing ?
Gene_expression (mIPSCs) of SDH in neurons associated with medulla and spinal cord
9) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.28
Expression of glycine, GABAA, and CB1 receptor subunits in SDH and DDH
Gene_expression (Expression) of SDH
10) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.03
The marked differences in GlyR-mediated mIPSC amplitude in SDH and DDH neurons could be attributable to specific properties of the GlyR, such as differences in single-channel conductance, number of receptors open during quantal release (No), or channel open probability (Po).
Gene_expression (neurons) of SDH in neurons
11) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.09
The decay time constant for mIPSCs was slower in SDH versus DDH neurons (8.5 ± 0.8 vs. 5.5 ± 0.3 ms), however, mIPSC rise times were identical in the two regions (0.85 ± 0.07 vs. 0.85 ± 0.04 ms). mIPSC frequency was lower in the SDH compared to the DDH (0.15 ± 0.03 vs. 0.72 ± 0.13 Hz).
Gene_expression (neurons) of SDH in neurons
12) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.12
2 ratio is higher in the SDH, whereas the Gly?
Gene_expression (higher) of SDH
13) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.11
In summary, methAEA reduced mIPSC frequency but had no direct effect on GlyRs located at synapses on either SDH or DDH neurons.


Gene_expression (neurons) of SDH in neurons
14) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.16
The only major difference we observed in mouse dorsal horn was a slower decay time constant (23 vs. 18 ms) in SDH versus DDH neurons.
Gene_expression (neurons) of SDH in neurons associated with dorsal horn
15) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.06 Pain Relevance 0.27
The type-one cannabinoid receptor (CB1R), which has long been known to be involved in analgesia [23,24], is also expressed at different levels in the SDH versus DDH [25].
Gene_expression (expressed) of SDH associated with cannabinoid receptor and analgesia
16) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.05 Pain Relevance 0.83
3 expression in the SDH as reported by Harvey et al., (2004) using immunohistochemistry.
Gene_expression (expression) of SDH
17) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.18
One explanation is that the somato-dendritic distribution of inhibitory synapses may differ for SDH versus DDH neurons.
Gene_expression (neurons) of SDH in neurons
18) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.10 Pain Relevance 0.03
Projections from the SDH terminate mostly in brainstem and midbrain centres such as the parabrachial nuclei and periaqueductal grey [14,15].
Gene_expression (Projections) of SDH in brainstem associated with medulla, periaqueductal grey, midbrain and parabrachial
19) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.27 Pain Relevance 0.51
In mice, however, we have shown that GlyR properties do not change in SDH neurons after P17 [39].
Gene_expression (neurons) of SDH in neurons
20) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.06

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