INT93388

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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) plasma membrane (Pdyn)
nucleus (Rbm39)
Rbm39 (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 32 100.00 Very High Very High Very High
nMDA receptor 3 100.00 Very High Very High Very High
nMDA receptor antagonist 1 96.18 Very High Very High Very High
Enkephalin 1 82.20 Quite High
Spinal cord 4 79.92 Quite High
Opioid 3 58.40 Quite High
antagonist 1 38.28 Quite Low
Antinociceptive 1 29.32 Quite Low
Endogenous opioid 1 28.04 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 3 99.36 Very High Very High Very High
Drug Induced Neurotoxicity 2 75.00 Quite High
Spinal Cord Injury 2 33.40 Quite Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NMDA receptor antagonist MK-801 (dizocilpine) (10 microM) significantly attenuated the neurotoxic effects of dynorphin A and/or dynorphin-derived fragments except dynorphin A (13-17), suggesting that the neurotoxic effects of dynorphin were largely mediated by NMDA receptors.
receptors Positive_regulation (mediated) of Positive_regulation (effects) of dynorphin associated with nmda receptor antagonist, dynorphin and nmda receptor
1) Confidence 0.03 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170722 Disease Relevance 0.32 Pain Relevance 1.40

General Comments

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