INT93395

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Context Info
Confidence 0.51
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.64
Pain Relevance 2.26

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signal transduction (Faslg) extracellular space (Faslg) extracellular region (Faslg)
cytoplasmic membrane-bounded vesicle (Faslg) plasma membrane (Faslg)
Anatomy Link Frequency
pancreas 2
acinar cells 2
Faslg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 96.20 Very High Very High Very High
Chronic pancreatitis 12 91.64 High High
Pain 12 82.12 Quite High
Inflammation 17 80.68 Quite High
cytokine 2 77.84 Quite High
COX2 2 25.00 Low Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 99.18 Very High Very High Very High
Cancer 2 98.68 Very High Very High Very High
Necrosis 2 98.44 Very High Very High Very High
Pancreatitis 12 91.64 High High
Injury 10 90.88 High High
Frailty 12 87.12 High High
Pain 10 82.12 Quite High
Disease 3 82.04 Quite High
INFLAMMATION 17 80.68 Quite High
Death 2 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fas and FasL mRNA were expressed when the pancreas was still pathologically normal, and showed a biphasic peak at 12 and 20 weeks.
Transcription (expressed) of FasL in pancreas
1) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.68 Pain Relevance 0.25
An apoptotic index in acinar cells correlated to the expression of Fas and FasL mRNAs.
Transcription (expression) of FasL in acinar cells associated with apoptosis
2) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.62 Pain Relevance 0.24
Fas and FasL mRNAs in the pancreas were detected with a reverse transcription-polymerase chain reaction method.
Transcription (detected) of FasL in pancreas
3) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.73 Pain Relevance 0.22
An apoptotic index in acinar cells correlated to the expression of Fas and FasL mRNA.
Transcription (expression) of FasL in acinar cells
4) Confidence 0.49 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.07 Pain Relevance 0
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Transcription (levels) of CD95-L associated with necrosis, cancer and apoptosis
5) Confidence 0.33 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.78 Pain Relevance 0.78
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Transcription (levels) of CD95 associated with necrosis, cancer and apoptosis
6) Confidence 0.33 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.77 Pain Relevance 0.78

General Comments

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