INT93396

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.59
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
parathyroid 6
thyroid 2
esophagus 2
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 24 96.40 Very High Very High Very High
Sciatic nerve 9 94.80 High High
fluoxetine 8 94.30 High High
5HT 6 82.40 Quite High
COX-2 inhibitor 21 82.24 Quite High
antagonist 1 82.12 Quite High
agonist 1 76.40 Quite High
sSRI 3 73.92 Quite High
Inflammation 28 73.84 Quite High
Pain 9 70.80 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 27 99.92 Very High Very High Very High
Thyroid Neoplasm 21 99.60 Very High Very High Very High
Mantle-cell Lymphoma 41 99.52 Very High Very High Very High
Parathyroid Cancer 120 99.00 Very High Very High Very High
Cancer 144 98.44 Very High Very High Very High
Adenocarcinoma 64 98.24 Very High Very High Very High
Intussusception 15 96.32 Very High Very High Very High
Lymphatic System Cancer 21 93.08 High High
Apoptosis 13 91.36 High High
Glioma 24 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased nuclear cyclin D1 expression was observed in 22 - 64% of the esophageal adenocarcinomas.33 Recent studies report that NSAIDs suppress cancer cell growth by inhibiting cyclin D1 expression.34,35
Positive_regulation (Increased) of Gene_expression (expression) of cyclin D1 associated with adenocarcinoma, cancer and cinod
1) Confidence 0.52 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.48 Pain Relevance 0.29
Cyclin D1 protein is overexpressed in human thyroid cancers that have causal links to environmental radiation exposures at nuclear test sites (Meirmanov et al. 2003).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Cyclin D1 in thyroid associated with thyroid neoplasm
2) Confidence 0.38 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.49 Pain Relevance 0
This study showed that cyclin D1 and PCNA expression were increased in the lower esophagus of rats exposed to gastroduodenal reflux contents.
Positive_regulation (increased) of Gene_expression (expression) of cyclin D1 in esophagus
3) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.45 Pain Relevance 0.34
Cyclin D1 expression was increased in rats undergoing EGDA compared with those undergoing the sham surgery and with the sulindac-treatment groups (Fig. 5).


Positive_regulation (increased) of Gene_expression (expression) of Cyclin D1
4) Confidence 0.35 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.38 Pain Relevance 0.14
This inhibition correlated significantly with reduced cyclin D1 and increased p21 protein expression.
Positive_regulation (increased) of Gene_expression (expression) of cyclin D1
5) Confidence 0.29 Published 2000 Journal Mol. Cell Biol. Res. Commun. Section Abstract Doc Link 11170841 Disease Relevance 0.15 Pain Relevance 0.21
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Positive_regulation (increased) of Gene_expression (expression) of cyclin D1 associated with fluoxetine
6) Confidence 0.28 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 0.95
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (expressions) of cyclin D1
7) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
Cyclin D1 overexpression is a feature of typical parathyroid adenomas as had been suggested by early DNA studies [7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 in parathyroid associated with parathyroid cancer
8) Confidence 0.12 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.02 Pain Relevance 0
Although His et al studied only three patients with parathyroid carcinoma, two of the patients tumors stained strongly for Cyclin D1, raising the possibility that the frequency of Cyclin D1 overexpression may be greater in carcinoma.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 in parathyroid associated with cancer, parathyroid cancer and carcinoma
9) Confidence 0.12 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.40 Pain Relevance 0.12
Cyclin D1 overexpression appears to highlight a central pathway in parathyroid neoplasia.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 in parathyroid associated with parathyroid cancer
10) Confidence 0.12 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.47 Pain Relevance 0.13
The combination of decreased pRb in the absence of functional p16 may cause the cell to lose adequate control over the pRb pathway which is reinforced by the increase in cyclin D1 expression.
Positive_regulation (increase) of Gene_expression (expression) of cyclin D1
11) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.93 Pain Relevance 0
Additionally, cytogenetic analysis of MCL shows rearrangement of the bcl-1 locus on chromosome11 due to t (11:14) (q13:q32) translocation, accompanied by cyclin D1 antigen overexpression [15].
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with mantle-cell lymphoma
12) Confidence 0.07 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2732623 Disease Relevance 0.94 Pain Relevance 0
A translocation between chromosomes 11; 14 takes place, leading to the juxtaposition of the cyclin D1 and the consequent over- expression of the CCND1 gene [5].
Positive_regulation (leading) of Gene_expression (expression) of CCND1 gene
13) Confidence 0.03 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2933587 Disease Relevance 0.87 Pain Relevance 0.03

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