INT93398

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 2.61
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
RG2 2
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 33 99.36 Very High Very High Very High
Inflammation 36 98.52 Very High Very High Very High
fluoxetine 8 96.50 Very High Very High Very High
5HT 6 86.80 High High
antagonist 2 86.52 High High
agonist 1 80.80 Quite High
COX-2 inhibitor 30 76.20 Quite High
Serotonin 3 74.00 Quite High
sSRI 3 73.92 Quite High
Hippocampus 1 51.00 Quite High
Disease Link Frequency Relevance Heat
Glioblastoma 38 100.00 Very High Very High Very High
Cancer 95 99.68 Very High Very High Very High
Adenocarcinoma 85 98.62 Very High Very High Very High
INFLAMMATION 43 98.52 Very High Very High Very High
Retinoblastoma 1 82.76 Quite High
Reprotox - General 1 2 80.40 Quite High
Death 3 59.68 Quite High
Apoptosis 34 57.84 Quite High
Malignant Neoplastic Disease 15 50.00 Quite Low
Brain Tumor 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, sulindac treatment reduced cyclin D1 expression.
Negative_regulation (reduced) of Gene_expression (expression) of cyclin D1
1) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.46 Pain Relevance 0.31
We suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.



Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1 associated with inflammation
2) Confidence 0.32 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628171 Disease Relevance 0.45 Pain Relevance 0.09
In conclusion, we suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.



Negative_regulation (decreased) of Gene_expression (expression) of cyclin D1 associated with inflammation
3) Confidence 0.32 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.46 Pain Relevance 0.23
Increased nuclear cyclin D1 expression was observed in 22 - 64% of the esophageal adenocarcinomas.33 Recent studies report that NSAIDs suppress cancer cell growth by inhibiting cyclin D1 expression.34,35
Negative_regulation (inhibiting) of Gene_expression (expression.34,35) of cyclin D1 associated with adenocarcinoma, cancer and cinod
4) Confidence 0.32 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.47 Pain Relevance 0.26
Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of cyclin D1
5) Confidence 0.28 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Negative_regulation (decrease) of Gene_expression (expression) of cyclin D1
6) Confidence 0.28 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
This inhibition correlated significantly with reduced cyclin D1 and increased p21 protein expression.
Negative_regulation (reduced) of Gene_expression (expression) of cyclin D1
7) Confidence 0.24 Published 2000 Journal Mol. Cell Biol. Res. Commun. Section Abstract Doc Link 11170841 Disease Relevance 0.15 Pain Relevance 0.21
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Negative_regulation (inhibitor) of Gene_expression (expression) of cyclin D1 associated with fluoxetine
8) Confidence 0.18 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.02
The protein expression of cdk2, cdk4, cdk6, cyclin D1 and cyclin E in BP-treated GBM cells was also measured, and all five proteins were decreased in DBTRG-05MG and DBTRG 8401 cells; similar results for cdk2, cdk4, cdk6, cyclin D1, cyclin E and p21 were detected in RG2 cells after treatment with BP (Fig. 2b).
Negative_regulation (measured) of Gene_expression (expression) of cyclin D1 in RG2 associated with glioblastoma
9) Confidence 0.05 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.47 Pain Relevance 0

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