INT93399

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 21.00
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
parathyroid 5
esophagus 2
RG2 2
mammary gland 1
thyroid 1
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 75 99.14 Very High Very High Very High
Inflammation 106 98.52 Very High Very High Very High
Sciatic nerve 11 94.24 High High
fluoxetine 8 94.10 High High
COX-2 inhibitor 72 91.60 High High
5HT 6 82.00 Quite High
antagonist 44 81.72 Quite High
agonist 15 76.00 Quite High
sSRI 3 73.92 Quite High
Kinase C 10 73.52 Quite High
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 82 99.94 Very High Very High Very High
Carcinoma 57 99.92 Very High Very High Very High
Breast Cancer 41 99.68 Very High Very High Very High
Thyroid Neoplasm 24 99.60 Very High Very High Very High
Cancer 719 99.46 Very High Very High Very High
Parathyroid Cancer 240 99.08 Very High Very High Very High
Glioma 96 98.96 Very High Very High Very High
Glioblastoma 76 98.88 Very High Very High Very High
Apoptosis 116 98.68 Very High Very High Very High
Adenocarcinoma 217 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased nuclear cyclin D1 expression was observed in 22 - 64% of the esophageal adenocarcinomas.33 Recent studies report that NSAIDs suppress cancer cell growth by inhibiting cyclin D1 expression.34,35
Gene_expression (expression) of cyclin D1 associated with adenocarcinoma, cancer and cinod
1) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.47 Pain Relevance 0.29
In conclusion, we suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.



Gene_expression (expression) of cyclin D1 associated with inflammation
2) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.46 Pain Relevance 0.20
In addition, sulindac treatment reduced cyclin D1 expression.
Gene_expression (expression) of cyclin D1
3) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.46 Pain Relevance 0.31
Increased proliferating cells and an expanded proliferative compartment were demonstrated in Barrett's esophagus and adenocarcinoma.31,32 Therefore, we studied the localization of BrdU-labeled cells and cyclin D1 expression.
Gene_expression (expression) of cyclin D1 in esophagus associated with adenocarcinoma
4) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.60 Pain Relevance 0.34
This study showed that cyclin D1 and PCNA expression were increased in the lower esophagus of rats exposed to gastroduodenal reflux contents.
Gene_expression (expression) of cyclin D1 in esophagus
5) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.45 Pain Relevance 0.33
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Gene_expression (expression) of cyclin D1
6) Confidence 0.51 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.
Spec (determine) Gene_expression (expression) of cyclin D1
7) Confidence 0.51 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0
Cyclin D1 protein is overexpressed in human thyroid cancers that have causal links to environmental radiation exposures at nuclear test sites (Meirmanov et al. 2003).
Gene_expression (overexpressed) of Cyclin D1 in thyroid associated with thyroid neoplasm
8) Confidence 0.51 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.49 Pain Relevance 0
Increased nuclear cyclin D1 expression was observed in 22 - 64% of the esophageal adenocarcinomas.33 Recent studies report that NSAIDs suppress cancer cell growth by inhibiting cyclin D1 expression.34,35
Gene_expression (expression.34,35) of cyclin D1 associated with adenocarcinoma, cancer and cinod
9) Confidence 0.51 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.47 Pain Relevance 0.26
Cyclin D1 expression was increased in rats undergoing EGDA compared with those undergoing the sham surgery and with the sulindac-treatment groups (Fig. 5).


Gene_expression (expression) of Cyclin D1
10) Confidence 0.45 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.38 Pain Relevance 0.14
Cyclin D1 expression was negligible in the sulindac-treated group compared with the control group.


Gene_expression (expression) of Cyclin D1
11) Confidence 0.45 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628171 Disease Relevance 0.38 Pain Relevance 0.04
COX-2, cyclin D1, and PCNA expression
Gene_expression (expression) of cyclin D1
12) Confidence 0.45 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.39 Pain Relevance 0.03
We suggest that the chemopreventive effect of sulindac is related to decreased COX-2 and cyclin D1 expression, which may be influenced by reduced inflammation.



Gene_expression (expression) of cyclin D1 associated with inflammation
13) Confidence 0.45 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628171 Disease Relevance 0.45 Pain Relevance 0.09
This inhibition correlated significantly with reduced cyclin D1 and increased p21 protein expression.
Gene_expression (expression) of cyclin D1
14) Confidence 0.38 Published 2000 Journal Mol. Cell Biol. Res. Commun. Section Abstract Doc Link 11170841 Disease Relevance 0.15 Pain Relevance 0.21
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Gene_expression (expression) of cyclin D1 associated with fluoxetine
15) Confidence 0.32 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 0.95
The same difficulties are encountered when interpreting the results for expression levels of cyclin D1 and TGF-?
Gene_expression (expression) of cyclin D1
16) Confidence 0.29 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.26 Pain Relevance 0
Expression of cyclin D1 was lowest in mammary gland from age-matched virgin animals but was similar in mammary tissues from the two parous groups (Fig. 10).
Gene_expression (Expression) of cyclin D1 in mammary gland
17) Confidence 0.29 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.07 Pain Relevance 0
Expressions of cyclin D1 and transforming growth factor-?
Gene_expression (Expressions) of cyclin D1
18) Confidence 0.29 Published 2004 Journal Breast Cancer Res Section Abstract Doc Link PMC468665 Disease Relevance 0.50 Pain Relevance 0
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Gene_expression (expressions) of cyclin D1
19) Confidence 0.28 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
The regulation of cyclin D1 expression is also mediated by the Ras/ERK signaling pathways [181, 182].
Gene_expression (expression) of cyclin D1
20) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.08 Pain Relevance 0

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