INT934

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Context Info
Confidence 0.35
First Reported 1979
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 11.35
Pain Relevance 6.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
nerve 3
plasma 2
stellate cells 2
platelet 2
brain 1
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 22 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
gABA 4 100.00 Very High Very High Very High
dexamethasone 51 99.84 Very High Very High Very High
cytokine 17 99.80 Very High Very High Very High
c fibre 5 99.64 Very High Very High Very High
Hippocampus 6 99.32 Very High Very High Very High
spastic colon 4 99.26 Very High Very High Very High
anesthesia 7 98.12 Very High Very High Very High
Thalamus 4 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 17 100.00 Very High Very High Very High
Natriuresis 10 100.00 Very High Very High Very High
Renal Disease 6 99.44 Very High Very High Very High
Renal Failure 46 99.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 99.26 Very High Very High Very High
Functional Bowel Disorder 1 99.16 Very High Very High Very High
Toxicity 2 99.10 Very High Very High Very High
Diabetes Mellitus 273 98.12 Very High Very High Very High
Neuropathic Pain 10 97.68 Very High Very High Very High
Liver Failure 2 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study tested the effects of in vivo administration of brain-derived neurotrophic factor (BDNF) and of its antibody (anti-BDNF) in a Morris Water Maze (MWM) task.
Regulation (effects) of factor in brain
1) Confidence 0.35 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10863031 Disease Relevance 0.07 Pain Relevance 0.23
Earlier studies have demonstrated that the levels of prostacyclin synthesis stimulating plasma factor are changed during various clinical situations thus leading to disturbances in hemostatic balance.
Regulation (changed) of factor in plasma
2) Confidence 0.17 Published 1985 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3887434 Disease Relevance 0.28 Pain Relevance 0.07
Changes in nerve growth factor levels in dorsal root ganglia and spinal nerves in a rat neuropathic pain model.
Regulation (Changes) of factor in nerve associated with pain, nerve growth factor and neuropathic pain
3) Confidence 0.15 Published 2000 Journal Exp Brain Res Section Title Doc Link 10638445 Disease Relevance 0.27 Pain Relevance 0.66
Role of atrial natriuretic factor, hemodynamic changes and renal nerves in the renal effects of intraperitoneal morphine in conscious rats.
Regulation (Role) of factor in renal nerves associated with natriuresis and morphine
4) Confidence 0.12 Published 1997 Journal Kidney Blood Press. Res. Section Title Doc Link 9192906 Disease Relevance 0.53 Pain Relevance 0.40
The potential relationship between stress and irritable bowel syndrome (IBS) symptomatology suggests a possible role for stress-mediating hormones, such as corticotropin-releasing factor (CRF), in the altered perception of stimuli in IBS patients.
Spec (possible) Regulation (role) of factor in bowel associated with stress and spastic colon
5) Confidence 0.11 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15916629 Disease Relevance 0.51 Pain Relevance 0.37
The results suggest that relatively small changes in transfer factor may be detected without losing power, and thus that this model could be used as a biological exposure indicator.
Regulation (changes) of transfer factor
6) Confidence 0.10 Published 1994 Journal Clin Physiol Section Abstract Doc Link 8149710 Disease Relevance 0 Pain Relevance 0
The down-regulation of nerve growth factor (NGF) mRNA and protein expression in the cortex and thalamus at defined time points between 1 and 24h after the propofol treatment, as well as a decrease of phosphorylated Akt were observed.
Regulation (regulation) of factor in nerve associated with nerve growth factor and thalamus
7) Confidence 0.10 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19150648 Disease Relevance 0.50 Pain Relevance 0.30
The mean values of transfer factor, alveolar volume and transfer constant were 0.50 (0.09) mmol min-1 kPa-1, 127 (8) ml and 3.9 (0.6) mmol min-1 kPa-1 l-1, respectively.
Regulation (values) of transfer factor
8) Confidence 0.09 Published 1994 Journal Clin Physiol Section Abstract Doc Link 8149710 Disease Relevance 0 Pain Relevance 0
To examine the role of corticotropin-releasing factor (CRF) receptor antagonist on conditioned-withdrawal-induced reinstatement of CPP, different doses of alpha-helical CRF (0.1 and 1 mug, i.c.v.) were administered 30 min prior to the CPP testing.
Spec (examine) Regulation (role) of factor
9) Confidence 0.08 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15739075 Disease Relevance 0.07 Pain Relevance 0
The purpose of this study was to measure the changes in levels of nerve growth factor (NGF) in dorsal root ganglia (DRG) and spinal nerves with the aim of investigating the role of NGF in a rat neuropathic pain model.
Regulation (changes) of factor in dorsal root ganglia associated with nerve growth factor and neuropathic pain
10) Confidence 0.07 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10638445 Disease Relevance 0.26 Pain Relevance 0.38
SP induced changes in MIF, cyclooxygenase-2, nerve growth factor, c-fos and edema were decreased by intraluminal anti-MIF.
Regulation (changes) of factor in nerve
11) Confidence 0.05 Published 2004 Journal J. Urol. Section Body Doc Link 15371880 Disease Relevance 0.15 Pain Relevance 0
This prolactin-releasing factor (PRF)-like activity was not altered in plasma from rats treated with bromocryptine or chlorpromazine despite significant suppression and stimulation of plasma PRL levels, respectively.
Neg (not) Regulation (altered) of factor in plasma
12) Confidence 0.04 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 114870 Disease Relevance 0 Pain Relevance 0.28
Together, these findings suggest that an interaction exists between a benzodiazepine receptor mechanism(s) and regulation of hypothalamic corticotropin-releasing factor(s) which in turn controls beta-END-LI secretion from the AL of the rat pituitary gland.
Regulation (regulation) of factor in pituitary gland
13) Confidence 0.03 Published 1985 Journal Endocrinology Section Abstract Doc Link 2990851 Disease Relevance 0.07 Pain Relevance 0.18
Acute and chronic toxicity of standard PD fluids to mesothelial cells, affecting cell turnover and the pattern of growth factor and cytokine release, is considered a key mechanism underlying the progressive transformation of the peritoneum.
Regulation (affecting) of factor in mesothelial cells associated with toxicity, renal failure and cytokine
14) Confidence 0.03 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC529259 Disease Relevance 1.15 Pain Relevance 0.17
Indeed, variable urine Na+ excretion mechanism was introduced to control ECF [Na+] and volume (ANPs factor), as well as a Na+ retention mechanism (ALD factor).
Regulation (control) of factor in urine
15) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0 Pain Relevance 0
The effects of a naturally occurring deleted form of hepatocyte growth factor (HGF) on hepatic disorder were studied in various models of hepatic failure.
Regulation (effects) of factor in hepatocyte associated with liver failure
16) Confidence 0.03 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9548396 Disease Relevance 0.56 Pain Relevance 0.11
Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells.
Regulation (effects) of factor in stellate cells
17) Confidence 0.03 Published 2005 Journal Pancreas Section Title Doc Link 16025003 Disease Relevance 0.17 Pain Relevance 0.17
OBJECTIVE: The cytokines platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta1 are major factors influencing the transformation from the quiescent to the activated phenotype of pancreatic stellate cells (PSC), a process involved in the pathogenesis of chronic pancreatitis.
Regulation (influencing) of factor in platelet associated with primary sclerosing cholangitis, chronic pancreatitis and cytokine
18) Confidence 0.03 Published 2005 Journal Pancreas Section Abstract Doc Link 16025003 Disease Relevance 0.19 Pain Relevance 0.18
Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells.
Regulation (effects) of factor in stellate cells
19) Confidence 0.03 Published 2005 Journal Pancreas Section Title Doc Link 16025003 Disease Relevance 0.18 Pain Relevance 0.18
OBJECTIVE: The cytokines platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta1 are major factors influencing the transformation from the quiescent to the activated phenotype of pancreatic stellate cells (PSC), a process involved in the pathogenesis of chronic pancreatitis.
Regulation (influencing) of factor in platelet associated with primary sclerosing cholangitis, chronic pancreatitis and cytokine
20) Confidence 0.03 Published 2005 Journal Pancreas Section Abstract Doc Link 16025003 Disease Relevance 0.19 Pain Relevance 0.18

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