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Context Info
Confidence 0.33
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.77
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 11 99.36 Very High Very High Very High
Inflammation 9 85.68 High High
COX-2 inhibitor 8 68.36 Quite High
Bile 2 39.04 Quite Low
aspirin 2 22.88 Low Low
COX2 1 10.00 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 99.68 Very High Very High Very High
Adenocarcinoma 21 98.62 Very High Very High Very High
Apoptosis 2 90.64 High High
INFLAMMATION 12 85.68 High High
Retinoblastoma 1 82.76 Quite High
Reprotox - General 1 1 62.32 Quite High
Duodenogastric Reflux 1 31.88 Quite Low
Esophageal Cancer 2 24.52 Low Low
Body Weight 4 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition correlated significantly with reduced cyclin D1 and increased p21 protein expression.
Negative_regulation (reduced) of cyclin D1
1) Confidence 0.33 Published 2000 Journal Mol. Cell Biol. Res. Commun. Section Abstract Doc Link 11170841 Disease Relevance 0.15 Pain Relevance 0.21
Increased nuclear cyclin D1 expression was observed in 22 - 64% of the esophageal adenocarcinomas.33 Recent studies report that NSAIDs suppress cancer cell growth by inhibiting cyclin D1 expression.34,35
Negative_regulation (inhibiting) of cyclin D1 associated with adenocarcinoma, cancer and cinod
2) Confidence 0.32 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.47 Pain Relevance 0.26
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Negative_regulation (decrease) of cyclin D1
3) Confidence 0.17 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
For example, there is the down-regulation of cyclin D1, cyclin-dependent kinase 4, c-myc and Bcl-2 [19, 24].
Negative_regulation (regulation) of cyclin D1
4) Confidence 0.15 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.09 Pain Relevance 0

General Comments

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