INT93406

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Context Info
Confidence 0.14
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
thickening 2
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 99.70 Very High Very High Very High
qutenza 8 96.24 Very High Very High Very High
bradykinin 3 95.64 Very High Very High Very High
Deafferentation 1 87.88 High High
Calcitonin gene-related peptide 4 84.84 Quite High
antagonist 1 74.16 Quite High
cOX1 1 10.00 Low Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 38.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of gel thickening by indomethacin in response to multiple agonists suggests that cyclooxygenase activity is essential for duodenal gel thickness regulation.
Positive_regulation (essential) of Regulation (regulation) of cyclooxygenase in thickening associated with agonist
1) Confidence 0.14 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11171630 Disease Relevance 0 Pain Relevance 0.90
CONCLUSION: Piroxicam's oral clearance was impaired and its inhibitory effect on cyclooxygenase 1 activity was increased in CYP2C9*1/*2 or CYP2C9*1/*3 individuals, as compared with CYP2C 9*1 homozygous individuals.


Positive_regulation (increased) of Regulation (effect) of cyclooxygenase 1
2) Confidence 0.02 Published 2005 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16198655 Disease Relevance 0 Pain Relevance 0

General Comments

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