INT93427

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.50
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
neurons 1
brain 1
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 100.00 Very High Very High Very High
Clonidine 1 99.96 Very High Very High Very High
withdrawal 5 98.56 Very High Very High Very High
Dismenorea 2 98.40 Very High Very High Very High
COX-2 inhibitor 1 96.24 Very High Very High Very High
tolerance 1 94.16 High High
antagonist 1 92.48 High High
noradrenaline 3 91.40 High High
cytokine 1 91.08 High High
cINOD 4 90.04 High High
Disease Link Frequency Relevance Heat
Injury 7 99.82 Very High Very High Very High
Middle Cerebral Artery Infarction 12 98.80 Very High Very High Very High
Reprotox - General 1 2 98.40 Very High Very High Very High
Apoptosis 11 97.84 Very High Very High Very High
Death 5 96.56 Very High Very High Very High
Stroke 36 96.04 Very High Very High Very High
Neurodegenerative Disease 2 87.88 High High
Hypoxia 3 86.88 High High
Cv Unclassified Under Development 21 86.56 High High
Adhesions 1 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of PPARdelta leads to reduced 14-3-3e and hence a decline in Bad sequestration, resulting in an increased Bad-induced apoptosis via the mitochondrial death pathway.
Negative_regulation (decline) of Bad associated with apoptosis and death
1) Confidence 0.02 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.77 Pain Relevance 0.26
OBJECTIVE: To evaluate the effectiveness of GnRH agonist (GnRH-a) plus tibolone in the treatment of severe premenstrual syndrome (PMS).
Negative_regulation (effectiveness) of agonist associated with dismenorea and agonist
2) Confidence 0.02 Published 2001 Journal Fertil. Steril. Section Abstract Doc Link 11172843 Disease Relevance 0.17 Pain Relevance 0.22
The inhibitory effect of clonidine (alpha2-agonist; 1 mg/kg) on the accumulation of DOPA (15-41%) and 5-HTP (22-41%) was markedly decreased or abolished after chronic WIN and precipitated withdrawal, mainly in noradrenergic and serotonergic brain regions, which indicated desensitization of alpha2-autoreceptors and alpha2-heteroreceptors regulating the synthesis of noradrenaline and 5-HT.
Negative_regulation (abolished) of alpha2-agonist in brain associated with noradrenaline, agonist, withdrawal and clonidine
3) Confidence 0.02 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18709357 Disease Relevance 0 Pain Relevance 0.99
Administering melatonin prior to MCAO or at the onset of reperfusion restores the injury-induced reduction in phosphorylated AKT (p-AKT), p-Bad and Bcl-XL levels and the binding of p-Bad and 14-3-3 as well as decreases caspase-3 activation.38,39 Treatment of melatonin also suppresses the immunoreactivity of cytosolic cytochrome c oxdiase in the ischemic cortex four and 24 hours after MCAO.40 To investigate whether melatonin directly inhibits neuronal apoptosis after hypoxia/ischemia, mouse striatal neurons are cultured and subjected to oxygen and glucose deprivation (OGD).
Negative_regulation (reduction) of p-Bad in neurons associated with hypoxia, middle cerebral artery infarction, ischemia, injury and neurodegenerative disease
4) Confidence 0.02 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 1.55 Pain Relevance 0.16

General Comments

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