INT9344

Context Info Confidence 0.28 First Reported 1992 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.74 Pain Relevance 0.37

Anatomy Link Frequency dendritic cells 1 Atp9a (Mus musculus)

Pain Link Frequency Relevance Heat Pain 5 91.16 cytokine 9 50.52 Inflammation 8 50.12 qutenza 2 42.84 Snapping jaw 1 27.68 headache 1 10.00 dexamethasone 4 5.00 Multiple sclerosis 3 5.00 Potency 3 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Ileus 4 97.48 Dislocations 3 96.72 Acute Erythroblastic Leukemia 1 93.12 Lymphatic System Cancer 24 91.32 Pain 3 91.16 Malocclusion 1 89.96 Recurrence 3 89.04 Syndrome 1 83.44 Cancer 55 81.92 Toxicity 18 78.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastrointestinal transit and ileus in mice.

Regulation (Effects) of IIa associated with ileus

1) Confidence 0.28 Published 1999 Journal Bioorg. Med. Chem. Section Title Doc Link 10482465 Disease Relevance 0.33 Pain Relevance 0

The cumulative treatment and retention effects were compared with a sample of untreated Class II controls matched for age, sex, and mandibular plane angle.

Regulation (controls) of Class II

2) Confidence 0.22 Published 1999 Journal Am J Orthod Dentofacial Orthop Section Abstract Doc Link 10511673 Disease Relevance 0.09 Pain Relevance 0

Recent studies suggest that it has only weak inhibitory effect on class IIa enzymes (Bradner et al. 2010).

Regulation (effect) of IIa

3) Confidence 0.02 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.56 Pain Relevance 0.05

The PB has been proved to be most effective in Groups Ia, IIa and IVb although it is beneficial in half the cases in Groups IIb and III.

Regulation (effective) of IIa

4) Confidence 0.01 Published 1992 Journal Prosthet Orthot Int Section Abstract Doc Link 1408668 Disease Relevance 0.69 Pain Relevance 0.32

Thus, this randomized, controlled clinical trial provides Class II evidence of no effect on primary and secondary endpoints of 4 dosage regimens of IM IFNbeta-1a added to IVIg in persons with CIDP.

Neg (no) Regulation (effect) of Class II

5) Confidence 0.01 Published 2010 Journal Neurology Section Body Doc Link 20177118 Disease Relevance 0 Pain Relevance 0

The urease of H. pylori can also bind to CD74 (the class II-associated invariant chain that regulate the intracellular transport and functions of class II) to affect the cell motility of dendritic cells [36], or cause megasome formation [37].

Regulation (regulate) of class II in dendritic cells

6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.