INT93451

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 29.09
Pain Relevance 31.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
forebrain 24
cingulate cortex 8
neurons 4
cortex 4
hippocampus 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 987 100.00 Very High Very High Very High
Anterior cingulate cortex 685 100.00 Very High Very High Very High
Central grey 464 100.00 Very High Very High Very High
Glutamate 267 100.00 Very High Very High Very High
Inflammation 252 99.98 Very High Very High Very High
long-term potentiation 690 99.92 Very High Very High Very High
Lasting pain 284 99.92 Very High Very High Very High
Morphine 270 99.78 Very High Very High Very High
IPN 107 99.72 Very High Very High Very High
Anterior cingulate 6 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 467 100.00 Very High Very High Very High
Targeted Disruption 432 99.98 Very High Very High Very High
INFLAMMATION 252 99.98 Very High Very High Very High
Pain 557 99.92 Very High Very High Very High
Inflammatory Pain 107 99.72 Very High Very High Very High
Anxiety Disorder 202 99.64 Very High Very High Very High
Immunization 6 99.02 Very High Very High Very High
Bone Cancer 41 99.00 Very High Very High Very High
Injury 236 98.84 Very High Very High Very High
Nervous System Injury 67 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with targeted disruption and ipn
1) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.56 Pain Relevance 0.44
Genetic enhancement of inflammatory pain by forebrain NR2B overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with pain and ipn
2) Confidence 0.68 Published 2001 Journal Nat. Neurosci. Section Title Doc Link 11175877 Disease Relevance 0.84 Pain Relevance 0.89
For example, peripheral inflammation at one hindpaw in adult mice increased the expression level of NR2B proteins in the ACC [17].
Positive_regulation (increased) of Gene_expression (expression) of NR2B associated with inflammation and anterior cingulate cortex
3) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.69 Pain Relevance 0.56
We have demonstrated that inflammation-related pain was selectively increased in mice with forebrain-targeted NR2B overexpression, while physiological or acute pain is not affected [12].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with pain, inflammation and acute pain
4) Confidence 0.68 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.57 Pain Relevance 0.61
Does genetically overexpression of NR2B mimic physiological or pathological conditions?
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B
5) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.97 Pain Relevance 0.92
However, a previous study using genetic overexpression of NR2B subunits indicate the involvement of NMDA NR2B receptor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B
6) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.09 Pain Relevance 0.82
These findings are in good accord with previous genetic studies that forebrain NR2B overexpression enhanced spatial and fear memory [30].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with anxiety disorder
7) Confidence 0.63 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.63 Pain Relevance 0.39
Painful stimuli potentiate the prefrontal synaptic transmission and induce glutamate NMDA NR2B receptor expression in the ACC.
Positive_regulation (induce) of Gene_expression (expression) of NMDA NR2B receptor in ACC associated with pain, glutamate and anterior cingulate cortex
8) Confidence 0.60 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18410946 Disease Relevance 0.56 Pain Relevance 1.23
We studied the effect of forebrain-targeted overexpression of the NMDA receptor subunit NR2B on the response of mice to tissue injury and inflammation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NMDA receptor subunit NR2B in forebrain associated with inflammation, nmda receptor and injury
9) Confidence 0.60 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11175877 Disease Relevance 0.79 Pain Relevance 0.57
Such genetic manipulation of NMDA NR2B subunit overexpression can be at least mimicked in pathological conditions.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NMDA NR2B subunit
10) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.65 Pain Relevance 0.58
The importance of NMDA receptor NR2B subunit in hippocampal LTP and behavioral learning has been demonstrated by studies using transgenic mice with forebrain overexpression of NR2B subunits [11].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with targeted disruption, nmda receptor and long-term potentiation
11) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.42 Pain Relevance 1.00
In a recent study we found that after persistent inflammation (the Complete Freund's Adjuvant (CFA) animal model for chronic inflammation), the expression of NMDA NR2B receptors in the ACC was increased over a long-period of time, thereby increasing the NR2B component in NMDA receptor mediated EPSCs [17] (see Figure 3A, B).
Positive_regulation (increased) of Gene_expression (expression) of NMDA NR2B associated with inflammation, nmda receptor and anterior cingulate cortex
12) Confidence 0.55 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 1.09 Pain Relevance 1.10
Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC).
Positive_regulation (increased) of Gene_expression (expression) of NR2B in cingulate cortex associated with inflammation and anterior cingulate cortex
13) Confidence 0.50 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.61 Pain Relevance 0.59
Taken together, these results suggest that chronic morphine treatment increases both synaptic and extrasynaptic NR2B NMDA receptor activity.


Positive_regulation (increases) of Gene_expression (extrasynaptic) of NR2B associated with nmda receptor and morphine
14) Confidence 0.49 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 1.12
Although we are still unclear about the exact molecular mechanism for the NR2B containing NMDA receptor in morphine tolerance, one possible mechanism is that NR2B containing NMDA receptor may contribute to the induction of the synaptic process that may contribute to the establishment of morphine tolerance.
Positive_regulation (induction) of Gene_expression (containing) of NR2B associated with nmda receptor, tolerance and morphine
15) Confidence 0.49 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0 Pain Relevance 2.22
The results demonstrate a significant increase in NR2B expression in the lateral areas of the PAG (LPAG).
Positive_regulation (increase) of Gene_expression (expression) of NR2B in lateral areas associated with central grey
16) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.01 Pain Relevance 1.25
As shown in Fig. 2, expression of NR2B subunit was significantly increased in the LPAG of CFA-injected mice (n = 5) as compared with control mice (n = 6).
Positive_regulation (increased) of Gene_expression (expression) of NR2B
17) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.08 Pain Relevance 0.65
Our results show that NR2B expression is increased in the PAG after peripheral injury, suggesting that inhibition of the NR2B subunit may alter inflammation -induced behavioral responses.
Positive_regulation (increased) of Gene_expression (expression) of NR2B associated with inflammation, injury and central grey
18) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.06 Pain Relevance 0.63
In addition, forebrain overexpression of NR2B is sufficient for enhancement of inflammatory pain [35].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR2B in forebrain associated with ipn
19) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0.50 Pain Relevance 0.66
Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC).
Positive_regulation (increased) of Gene_expression (expression) of NR2B in cingulate cortex associated with inflammation and anterior cingulate cortex
20) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.62 Pain Relevance 0.60

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