INT93463

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.58
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt)
Anatomy Link Frequency
MnPO 2
olfactory bulb 2
hypothalamus 1
spinal 1
granule cells 1
Hcrt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 2 99.98 Very High Very High Very High
Neuropeptide 25 99.92 Very High Very High Very High
anesthesia 2 98.92 Very High Very High Very High
antiallodynic 3 98.72 Very High Very High Very High
cocaine 4 98.44 Very High Very High Very High
Clonidine 6 98.04 Very High Very High Very High
narcan 9 97.96 Very High Very High Very High
depression 1 97.80 Very High Very High Very High
agonist 2 97.32 Very High Very High Very High
Catecholamine 2 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1 99.36 Very High Very High Very High
Depression 1 97.80 Very High Very High Very High
Anxiety Disorder 2 97.16 Very High Very High Very High
Neuropathic Pain 3 93.68 High High
Stress 13 93.48 High High
Pain 1 92.68 High High
Pressure And Volume Under Development 6 87.12 High High
Post Operative Pain 2 75.00 Quite High
Recurrence 6 61.12 Quite High
Drug Dependence 1 53.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we compared hypocretin-1 and K(+)-evoked norepinephrine release from the cerebrocortical slices prepared from young-adult and middle-aged rats.
Localization (release) of hypocretin
1) Confidence 0.78 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885435 Disease Relevance 0.16 Pain Relevance 0.24
Endogenous orexin might be released after incision injury to activate the spinal OX1 receptors as an endogenous analgesic protector.
Localization (released) of orexin in spinal associated with analgesic and injury
2) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14551290 Disease Relevance 0.51 Pain Relevance 1.06
SB-334867 concentration-dependently inhibited orexin A-evoked norepinephrine release with pIC50 (Imax) of 6.05+/-0.14 (86.4+/-5.4%); clonidine (alpha2-agonist) was ineffective.
Localization (release) of orexin associated with agonist and clonidine
3) Confidence 0.78 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16085362 Disease Relevance 0 Pain Relevance 0.45
Similarly, hypocretin-1 evoked norepinephrine release from cerebrocortical slices prepared from young-adult rats was significantly higher than that of middle-aged rats whilst K(+)-evoked release did not differ between the groups.
Localization (release) of hypocretin
4) Confidence 0.73 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885435 Disease Relevance 0.17 Pain Relevance 0.18
This diverse set of functions is consistent with the localization of Hcrt neurons in the lateral hypothalamus, a major integrating center of sensory inputs and emotional processes, and their widespread excitatory projections throughout the brain.
Localization (localization) of Hcrt in hypothalamus
5) Confidence 0.69 Published 2010 Journal Curr Neurol Neurosci Rep Section Abstract Doc Link 20425032 Disease Relevance 0.38 Pain Relevance 0.19
These results indicate that orexin-A, but not orexin-B, suppresses GnRH secretion via beta-endorphin.
Localization (secretion) of orexin-A
6) Confidence 0.68 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11178985 Disease Relevance 0 Pain Relevance 0.31
MnPO is innervated by lateral hypothalamic neurons that synthesize and secrete the arousal-promoting and excitatory orexin (hypocretin) neuropeptides.
Localization (secrete) of orexin in MnPO associated with neuropeptide
7) Confidence 0.68 Published 2008 Journal Neuroscience Section Abstract Doc Link 18674591 Disease Relevance 0 Pain Relevance 0.14
MnPO is innervated by lateral hypothalamic neurons that synthesize and secrete the arousal-promoting and excitatory orexin (hypocretin) neuropeptides.
Localization (secrete) of hypocretin in MnPO associated with neuropeptide
8) Confidence 0.68 Published 2008 Journal Neuroscience Section Abstract Doc Link 18674591 Disease Relevance 0 Pain Relevance 0.14
In the present study, we have examined a possible interaction between orexinergic and alpha2-adrenergic systems in orexin-A (100 nM)- and K+ (25 mM)-evoked norepinephrine release from slices of rat cerebrocortex.
Localization (release) of orexin
9) Confidence 0.68 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16085362 Disease Relevance 0 Pain Relevance 0.32
Orexin A modulates mitral cell activity in the rat olfactory bulb: patch-clamp study on slices and immunocytochemical localization of orexin receptors.
Localization (localization) of orexin in olfactory bulb associated with neuropeptide
10) Confidence 0.55 Published 2005 Journal Endocrinology Section Title Doc Link 15976062 Disease Relevance 0 Pain Relevance 0.05
At the same ages, immunocytochemical data show that orexin 1 receptors are localized in the cell bodies of periglomerular, mitral/tufted, and granule cells.
Localization (localized) of orexin in granule cells
11) Confidence 0.55 Published 2005 Journal Endocrinology Section Abstract Doc Link 15976062 Disease Relevance 0 Pain Relevance 0.17
In the present study, RT-PCR experiments were done to determine orexin receptor expression during the early postnatal life of rats, and immunocytochemical experiments were performed to further clarify the structural and ultrastructural localization of orexin receptors in the olfactory bulb.
Localization (localization) of orexin in olfactory bulb
12) Confidence 0.55 Published 2005 Journal Endocrinology Section Abstract Doc Link 15976062 Disease Relevance 0 Pain Relevance 0
Orexin-A/hypocretin-1 has been shown to induce noradrenaline release (Hirota et al. 2001) and orexin-A/hypocretin-1 induced reinstatement of cocaine seeking has been blocked using CRF-1 and noradrenergic receptor antagonists (Boutrel et al. 2005).
Localization (release) of orexin-A associated with antagonist, noradrenaline and cocaine
13) Confidence 0.32 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0.37 Pain Relevance 0.26

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