INT93468

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 26
Disease Relevance 10.12
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn1) plasma membrane (Cldn1)
Anatomy Link Frequency
fat 4
epithelium 3
bile 2
surface epithelium 1
ileum 1
Cldn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 99.64 Very High Very High Very High
ischemia 355 99.38 Very High Very High Very High
Bile 704 98.56 Very High Very High Very High
Inflammation 124 97.84 Very High Very High Very High
cytokine 50 84.48 Quite High
IPN 2 75.00 Quite High
Lasting pain 1 67.20 Quite High
tolerance 55 66.64 Quite High
anesthesia 36 5.00 Very Low Very Low Very Low
Cholecystokinin 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 44 100.00 Very High Very High Very High
Reperfusion Injury 254 99.76 Very High Very High Very High
Pain 3 99.64 Very High Very High Very High
Cv Unclassified Under Development 303 99.38 Very High Very High Very High
INFLAMMATION 112 97.84 Very High Very High Very High
Pancreatitis 160 97.64 Very High Very High Very High
Cv General 4 Under Development 52 90.08 High High
Sprains And Strains 203 85.60 High High
Apoptosis 47 84.56 Quite High
Impaired Glucose Tolerance 88 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Claudin-1 protein expression was present at the BBB and remained unchanged during inflammation.
Gene_expression (expression) of Claudin-1 protein associated with inflammation
1) Confidence 0.27 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179069 Disease Relevance 0.90 Pain Relevance 0.68
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Gene_expression (expression) of claudin-1 in ileum
2) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.57 Pain Relevance 0.13
Claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin expression was observed in the recovering epithelium, but the reticular pattern was partly disrupted and irregular at the apical surfaces.
Gene_expression (expression) of Claudin-1 in epithelium
3) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.29 Pain Relevance 0.07
The reticular pattern of the tight junction protein ZO-1, occludin and claudin-1, -3, and -5 expression observed at 24 hr post-reperfusion may reflect the functional recovery of tight junctions.
Gene_expression (expression) of claudin-1
4) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.36 Pain Relevance 0.11
Concerning the role of claudin-2 in barrier function, Furuse et al. [7] showed that the addition of claudin-2 markedly decreased the barrier function measured by TER in MDCK-1 cells that endogenously expressed claudin-1 and -4.
Gene_expression (expressed) of claudin-1 in MDCK
5) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Claudin-1, claudin-3, claudin-5, ZO-1, and occludin were expressed in linear fashion along the whole surface of the epithelial cells from the crypts to the villi with a typical reticular pattern (Fig. 3A1, C1, E1–G1).
Gene_expression (expressed) of Claudin-1 in epithelial cells
6) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.66 Pain Relevance 0.15
Various cells, organs, and tissue compartments have unique distributions of the various claudins, and according to recent reports, claudin-1, -2, -3, -4, and -5 are strongly expressed in the rat intestine [9, 13].
Gene_expression (expressed) of claudin-1 in intestine
7) Confidence 0.26 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.21 Pain Relevance 0.16
To explore the mechanisms underlying the high fat-induced increase in intestinal permeability, we evaluated the expression of TJ proteins, occludin, claudin-1, claudin-3, and JAM-1, and their association with the actin cytoskeleton in the small intestine, cecum and colon of rats.
Gene_expression (expression) of claudin-1 in small intestine
8) Confidence 0.24 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.18 Pain Relevance 0
In the small intestine, claudin-1, claudin-3, and JAM-1 expression was influenced by diet (P < 0.05, 2-way ANOVA, Fig. 4), with high-fat feeding resulting in a decrease in expression.
Gene_expression (expression) of claudin-1 in fat
9) Confidence 0.24 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.20 Pain Relevance 0.06
Contrary to occludin and claudin-1, the pore-forming TJ protein, claudin-2 [7], was only scarcely detectable in crypts of sham-operated animals, whereas rats from the AP group showed intense staining of claudin-2 both in crypt and surface epithelium (fig 3).
Gene_expression (detectable) of claudin-1 in surface epithelium associated with pancreatitis
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.62 Pain Relevance 0
Claudin-1 was not detected near areas of epithelial disruption, suggesting that detachment of enterocytes was preceded by loss of claudin-1.
Neg (not) Gene_expression (detected) of Claudin-1 in enterocytes
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.73 Pain Relevance 0
At 24 hr post-reperfusion, villi had recovered and the reticular pattern of distribution of ZO-1, occludin and claudin-1, -3, and -5 expression had also reverted to resemble that in the non-treated, control samples (Fig. 3A4, C4, E4–G4).
Gene_expression (expression) of claudin-1
12) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.13 Pain Relevance 0.03
Using this model, we measured the intestinal mucosa-to-blood permeability by intraluminal administration of fluorescein isothiocyanate (FITC)-dextran and analyzed the expression of ZO-1, occludin and claudin-1, -2, -3, -4, and -5 by immunoconfocal microscopy.
Spec (analyzed) Gene_expression (expression) of claudin-1 in blood
13) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.56 Pain Relevance 0.21
The present study demonstrated that the expressions and localizations of multiple kinds of tight-junction proteins varied during recovery of intestinal barrier function in ischemia-reperfusion injury, i.e., the expression, especially with reticular pattern, of ZO-1, occludin and claudin-1, -3, and -5, was closely correlated with recovery of intestinal barrier function, whereas claudin-2 and claudin-4 showed unique changes in the expression.
Gene_expression (expression) of claudin-1 associated with reperfusion injury and ischemia
14) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.36 Pain Relevance 0.09
These data demonstrated that recovery of intestinal barrier function is associated with expression of ZO-1, occludin, and claudin-1, -3, and -5, whereas claudin-2 and claudin-4 show unique changes in expression and localization.



Gene_expression (expression) of claudin-1
15) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828083 Disease Relevance 0.62 Pain Relevance 0.14
From 6 to 24 hours post-reperfusion, villous epithelium was restored by cell migration, and barrier function together with reticular pattern expression of ZO-1, occludin, and claudin-1, -3, and -5, recovered time-dependently.
Gene_expression (expression) of claudin-1 in epithelium
16) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828083 Disease Relevance 0.72 Pain Relevance 0.16
In conclusion, we demonstrated that the expression, especially with reticular pattern, of multiple kinds of tight-junction proteins ZO-1, occludin and claudin-1, -3, and -5, was correlated with recovery of intestinal barrier function after ischemia-reperfusion injury.
Gene_expression (expression) of claudin-1 associated with reperfusion injury and ischemia
17) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.40 Pain Relevance 0.11
Occludin expression in the cells incubated with 10 and 20% bile juice were lower and higher than the control value, respectively, whereas the expression of JAM-1 and claudin-1 in cells incubated with 10 and 20% bile juice and claudin-3 in those incubated with 20% bile juice were all lower than the control value.
Gene_expression (expression) of claudin-1 in bile associated with bile
18) Confidence 0.19 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.05 Pain Relevance 0.34
The expression of JAM-1 and claudin-1 in cells treated with 0.5 and 1% fat emulsion and claudin-3 in those treated with 1% fat emulsion were all lower than the control value.


Gene_expression (expression) of claudin-1 in fat
19) Confidence 0.19 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.49 Pain Relevance 0.30
Feeding the high fat diet increased intestinal permeability in both the OLETF and LETO rats, and the increases correlated with decreases in TJ proteins (claudin-1, claudin-3, occludin and junctional adhesion molecule-1) expression in the small, but not in the large intestine (cecum or colon).
Gene_expression (expression) of claudin-1 in large intestine associated with adhesions
20) Confidence 0.19 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2848226 Disease Relevance 0.71 Pain Relevance 0.23

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