INT93470

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Context Info
Confidence 0.09
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Notch1, Prkcg) nucleus (Notch1, Prkcg) plasma membrane (Notch1, Prkcg)
cell differentiation (Notch1) Golgi apparatus (Notch1) intracellular (Prkcg)
Anatomy Link Frequency
nucleus 2
Notch1 (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 18 100.00 Very High Very High Very High
opioid receptor 5 90.96 High High
antagonist 5 88.80 High High
Opioid 4 75.80 Quite High
addiction 1 75.00 Quite High
ischemia 3 71.56 Quite High
Enkephalin 2 68.04 Quite High
MU agonist 1 66.64 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 71.56 Quite High
Myocardial Infarction 2 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAN-67 induced the translocation of PKC-alpha to the sarcolemma, PKC-beta(1) to the nucleus, PKC-delta to the mitochondria, and PKC-epsilon to the intercalated disk and mitochondria.
TAN-67 Positive_regulation (induced) of Localization (translocation) of PKC in nucleus associated with kinase c
1) Confidence 0.09 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179083 Disease Relevance 0.20 Pain Relevance 1.09
Finally, we demonstrate that genistein did not affect protein kinase C (PKC) translocation induced by TAN-67.
TAN-67 Positive_regulation (induced) of Localization (translocation) of PKC associated with kinase c
2) Confidence 0.06 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0.11 Pain Relevance 0.56

General Comments

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