INT93481

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 7.24
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
spinal cord 8
nucleus 4
skin 4
RAW 264 2
PC-3 2
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 36 99.98 Very High Very High Very High
Spinal cord 10 99.48 Very High Very High Very High
Inflammation 45 97.36 Very High Very High Very High
Hyperalgesia 5 95.20 Very High Very High Very High
Analgesic 19 91.72 High High
Sciatic nerve 1 88.64 High High
agonist 13 85.40 High High
Intracerebroventricular 6 75.00 Quite High
headache 2 73.08 Quite High
IPN 1 72.32 Quite High
Disease Link Frequency Relevance Heat
Necrosis 8 100.00 Very High Very High Very High
Cancer 8 100.00 Very High Very High Very High
Pressure And Volume Under Development 23 99.90 Very High Very High Very High
INFLAMMATION 40 97.36 Very High Very High Very High
Nociception 4 95.60 Very High Very High Very High
Neuropathic Pain 2 95.48 Very High Very High Very High
Hyperalgesia 6 95.20 Very High Very High Very High
Reprotox - General 1 10 91.04 High High
Sinusitis 1 73.96 Quite High
Toothache 1 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.
Negative_regulation (prevented) of Protein_catabolism (degradation) of IkB-alpha associated with hyperalgesia
1) Confidence 0.39 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.62 Pain Relevance 0.86
PEA prevented IkB-alpha degradation and NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
Negative_regulation (prevented) of Protein_catabolism (degradation) of IkB-alpha associated with inflammation
2) Confidence 0.36 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.51 Pain Relevance 0.50
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (evaluated) of Protein_catabolism (degradation) of kappaB-alpha in spinal cord associated with pressure and volume under development and spinal cord
3) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.55
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (inhibitor) of Protein_catabolism (degradation) of kappaB-alpha in spinal cord associated with pressure and volume under development and spinal cord
4) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.52 Pain Relevance 0.55
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (evaluated) of Protein_catabolism (degradation) of I kappa B-alpha in spinal cord associated with pressure and volume under development and spinal cord
5) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.53 Pain Relevance 0.55
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Negative_regulation (inhibitor) of Protein_catabolism (degradation) of I kappa B-alpha in spinal cord associated with pressure and volume under development and spinal cord
6) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.52 Pain Relevance 0.55
Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IkappaBalpha, preventing the activation of NF-kappaB.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of IkappaBalpha associated with qutenza
7) Confidence 0.20 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16540674 Disease Relevance 0.54 Pain Relevance 0.88
In further studies, capsaicin inhibited tumor necrosis factor-alpha-stimulated degradation of IkappaBalpha in PC-3 cells, which was associated with the inhibition of proteasome activity.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of IkappaBalpha in PC-3 associated with necrosis, qutenza and cancer
8) Confidence 0.15 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16540674 Disease Relevance 0.57 Pain Relevance 0.88
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of IkappaB-alpha in skin associated with qutenza
9) Confidence 0.08 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.19 Pain Relevance 0.58
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Negative_regulation (blockade) of Protein_catabolism (degradation) of IkappaB-alpha in skin associated with qutenza
10) Confidence 0.06 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.58
Furthermore, EAAD suppressed LPS-induced phosphorylation of p38 MAPK and extracellular-signal regulated kinases 1/2 (ERK1/2), I-kappaBalpha degradation, and NF-kappaB activation in RAW 264.7 cells.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of I-kappaBalpha in RAW 264
11) Confidence 0.04 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17229575 Disease Relevance 1.07 Pain Relevance 0.27
The NF-kappaB complex was composed of p50 and p65 subunits and its activation required inhibitor of NF-kappaBalpha degradation.
Negative_regulation (inhibitor) of Protein_catabolism (degradation) of NF-kappaBalpha
12) Confidence 0.01 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17896809 Disease Relevance 0.14 Pain Relevance 0
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (blocking) of Protein_catabolism (degradation) of IkappaB-alpha in nucleus
13) Confidence 0.01 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.23
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (inhibitor) of Protein_catabolism (degradation) of IkappaB-alpha in nucleus
14) Confidence 0.01 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.23

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