INT93482

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 56
Total Number 56
Disease Relevance 24.52
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
nucleus 8
astrocytes 2
lung 2
microglia 1
granulocyte 1
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 893 100.00 Very High Very High Very High
Morphine 780 99.56 Very High Very High Very High
agonist 76 99.36 Very High Very High Very High
palliative 2 98.38 Very High Very High Very High
Inflammation 510 97.92 Very High Very High Very High
Substantia nigra 112 96.64 Very High Very High Very High
Hyperalgesia 5 96.44 Very High Very High Very High
qutenza 11 96.28 Very High Very High Very High
opiate 182 94.04 High High
Inflammatory response 90 93.24 High High
Disease Link Frequency Relevance Heat
Cancer 436 100.00 Very High Very High Very High
Necrosis 56 100.00 Very High Very High Very High
Hepatitis C Virus Infection 103 99.52 Very High Very High Very High
Injury 115 99.40 Very High Very High Very High
Infection 175 99.34 Very High Very High Very High
Epstein-barr Virus 6 99.12 Very High Very High Very High
Pancreatic Cancer 488 98.88 Very High Very High Very High
Respiratory Syncytial Virus 300 98.52 Very High Very High Very High
Sepsis 14 97.96 Very High Very High Very High
Pneumonia 31 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.
Localization (translocation) of p65
1) Confidence 0.78 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.28 Pain Relevance 0.19
In further studies, NNU-hdpa was found to significantly inhibit the productions of PGE(2) and LTB(4) in LPS-challenged RAW 264.7, which is parallel to its prevention of the nuclear translocation of the NF-kappaB p50 and p65 subunits.
Localization (translocation) of p65 in RAW 264
2) Confidence 0.78 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345206 Disease Relevance 0.45 Pain Relevance 0.29
PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.
Localization (translocation) of p65 associated with hyperalgesia
3) Confidence 0.78 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.61 Pain Relevance 0.81
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Localization (translocation) of p65 associated with morphine
4) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.78
B and reduced Tat±morphine-induced increases in p65 nuclear translocation.
Localization (translocation) of p65 associated with morphine
5) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.36
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Localization (translocation) of RelA associated with morphine
6) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.79
phosphorylation, the rate of p65 translocation into the nucleus, and NF-?
Localization (translocation) of p65 in nucleus
7) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.24 Pain Relevance 0.98
In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.
Localization (localization) of p65 associated with apoptosis, death and palliative
8) Confidence 0.52 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.45 Pain Relevance 0.10
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Localization (translocation) of p65 in skin associated with qutenza
9) Confidence 0.51 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.59
Conversely, adding excess extracellular Ca2+ accelerated translocation of p65 (RelA) into the nucleus in all treated groups.
Localization (translocation) of RelA in nucleus
10) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.75
Conversely, adding excess extracellular Ca2+ accelerated translocation of p65 (RelA) into the nucleus in all treated groups.
Localization (translocation) of p65 in nucleus
11) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.75
In the present study, treatment with LMB blocked cytokine production, despite the continued presence of nuclear p65 (RelA), indicating that NF-?
Localization (presence) of p65 associated with cytokine
12) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.63
In the present study, treatment with LMB blocked cytokine production, despite the continued presence of nuclear p65 (RelA), indicating that NF-?
Localization (presence) of RelA associated with cytokine
13) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.63
In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.
Localization (accumulation) of p65 associated with apoptosis, death and palliative
14) Confidence 0.48 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.44 Pain Relevance 0.10
Note that some p65 (RelA) nuclear shuttling occurs in vehicle-treated astrocytes suggesting that tonic levels of nucleocytoplasmic shuttling occur and that other events such as the phosphorylation of specific NF-?
Localization (shuttling) of RelA in astrocytes
15) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.57
Note that some p65 (RelA) nuclear shuttling occurs in vehicle-treated astrocytes suggesting that tonic levels of nucleocytoplasmic shuttling occur and that other events such as the phosphorylation of specific NF-?
Localization (shuttling) of p65 in astrocytes
16) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.57
B p65 than WT groups, however, within Fc?
Localization (however) of p65
17) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.06 Pain Relevance 0.06
In our model, we observed increased mRNA for both p65 and p50, but only the p65 protein exhibited prominent accumulation in microglia.
Localization (mRNA) of p65 in microglia
18) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0
B p65 was decreased, rather than increased, in the Fc?
Localization (decreased) of p65
19) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.21 Pain Relevance 0.16
B2, RelA), or 10 seconds (?
Localization (seconds) of RelA
20) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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