INT93483

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.10
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
RAW 264 2
skin 2
lung 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 139 100.00 Very High Very High Very High
agonist 56 99.80 Very High Very High Very High
palliative 1 98.74 Very High Very High Very High
qutenza 8 96.72 Very High Very High Very High
Hyperalgesia 5 96.44 Very High Very High Very High
Inflammation 111 94.16 High High
aspirin 1 93.40 High High
Morphine 156 92.24 High High
Sciatic nerve 1 88.64 High High
Analgesic 5 87.00 High High
Disease Link Frequency Relevance Heat
Apoptosis 79 98.18 Very High Very High Very High
Death 15 97.64 Very High Very High Very High
Hyperalgesia 6 96.44 Very High Very High Very High
Necrosis 7 96.36 Very High Very High Very High
Cancer 62 96.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 95.40 Very High Very High Very High
INFLAMMATION 131 94.16 High High
Neuropathic Pain 1 90.76 High High
Atherosclerotic Plaque 2 89.48 High High
Pressure And Volume Under Development 7 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.
Negative_regulation (prevented) of Localization (translocation) of p65
1) Confidence 0.57 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.28 Pain Relevance 0.19
In further studies, NNU-hdpa was found to significantly inhibit the productions of PGE(2) and LTB(4) in LPS-challenged RAW 264.7, which is parallel to its prevention of the nuclear translocation of the NF-kappaB p50 and p65 subunits.
Negative_regulation (prevention) of Localization (translocation) of p65 in RAW 264
2) Confidence 0.41 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345206 Disease Relevance 0.46 Pain Relevance 0.29
PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.
Negative_regulation (prevented) of Localization (translocation) of p65 associated with hyperalgesia
3) Confidence 0.41 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.62 Pain Relevance 0.87
In the present study, treatment with LMB blocked cytokine production, despite the continued presence of nuclear p65 (RelA), indicating that NF-?
Negative_regulation (blocked) of Localization (presence) of p65 associated with cytokine
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.10 Pain Relevance 0.64
In the present study, treatment with LMB blocked cytokine production, despite the continued presence of nuclear p65 (RelA), indicating that NF-?
Negative_regulation (blocked) of Localization (presence) of RelA associated with cytokine
5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.10 Pain Relevance 0.64
In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.
Negative_regulation (decreased) of Localization (accumulation) of p65 associated with apoptosis, death and palliative
6) Confidence 0.28 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.44 Pain Relevance 0.10
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Negative_regulation (inhibition) of Localization (translocation) of p65 in skin associated with qutenza
7) Confidence 0.27 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.59
degradation, block p65 nuclear translocation and phosphorylation, and finally, down-regulate the expression levels of NF-?
Negative_regulation (block) of Localization (translocation) of p65
8) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.26 Pain Relevance 0
Moreover, we also demonstrate that the selective and potent LXR agonist T0901317 inhibited the nuclear translocation of p65 in the lung tissues at 4 h after carrageenan administration.
Negative_regulation (inhibited) of Localization (translocation) of p65 in lung associated with agonist
9) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.29 Pain Relevance 0.32
B (by preventing p65 nuclear translocation) following irradiation thereby inhibiting the microglial proinflammatory response [107].
Negative_regulation (preventing) of Localization (translocation) of p65
10) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.30 Pain Relevance 0.26
, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) by inhibiting the translocation of the p65 subunit of nuclear factor ?
Negative_regulation (inhibiting) of Localization (translocation) of p65 subunit
11) Confidence 0.01 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 1.08 Pain Relevance 0.29

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