INT93484

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 9.31
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
liver 2
striatum 2
proximal 2
epidermis 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 83 99.98 Very High Very High Very High
qutenza 24 99.98 Very High Very High Very High
Inflammation 167 99.72 Very High Very High Very High
COX2 5 99.58 Very High Very High Very High
Hippocampus 14 98.32 Very High Very High Very High
cytokine 49 96.32 Very High Very High Very High
Analgesic 3 94.60 High High
Inflammatory response 11 93.28 High High
COX-2 inhibitor 9 91.28 High High
cINOD 16 89.32 High High
Disease Link Frequency Relevance Heat
Stress 70 100.00 Very High Very High Very High
INFLAMMATION 197 99.72 Very High Very High Very High
Apoptosis 101 97.84 Very High Very High Very High
Cancer 214 97.24 Very High Very High Very High
Repression 6 95.80 Very High Very High Very High
Injury 19 93.76 High High
Ventricular Remodeling 1 92.96 High High
Sepsis 1 91.76 High High
Neuropathic Pain 3 90.92 High High
Myocardial Infarction 26 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of AP-1 can be inhibited by numerous natural product polyphenols such as resveratrol, curcumin, epigallocatechin gallate and theaflavins [6,15,16].
Negative_regulation (inhibited) of Positive_regulation (Activation) of AP-1
1) Confidence 0.58 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.32 Pain Relevance 0.09
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Negative_regulation (reduced) of Positive_regulation (induction) of immediate early in liver
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.06 Pain Relevance 0
However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B (UVB) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells.
Negative_regulation (suppressed) of Positive_regulation (activation) of AP-1
3) Confidence 0.56 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12433932 Disease Relevance 0.18 Pain Relevance 0.18
Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment.
Negative_regulation (abolished) of Positive_regulation (activation) of activator protein-1 associated with qutenza
4) Confidence 0.50 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.17 Pain Relevance 0.59
The ability of resveratrol to inhibit the stress-induced activation of AP-1 has been reported in a number of studies.
Negative_regulation (inhibit) of Positive_regulation (activation) of AP-1 associated with stress
5) Confidence 0.43 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.24 Pain Relevance 0
Numerous plant polyphenols have been shown to inhibit the activation of AP-1, which often is ascribed to the anti-oxidant properties of these natural products.


Negative_regulation (inhibit) of Positive_regulation (activation) of AP-1
6) Confidence 0.43 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2632638 Disease Relevance 0.38 Pain Relevance 0.10
Inhibition or enhancement of the TPA-induced activation of AP-1 by methoxy-substituted trans-stilbenes
Negative_regulation (Inhibition) of Positive_regulation (activation) of AP-1
7) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
For example, resveratrol suppressed TNF-induced activation of AP-1 in a variety of cells through inhibition of activation of MAP kinases [17].
Negative_regulation (suppressed) of Positive_regulation (activation) of AP-1
8) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.31 Pain Relevance 0.08
Some of these trans-stilbenes, such as 8, 9, 10and 11, were strong inhibitors of the TPA-induced activation of AP-1 with IC50 values in the range 0.7 to 3.8 ?
Negative_regulation (inhibitors) of Positive_regulation (activation) of AP-1
9) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
In this series, many compounds were strong inhibitors of the TPA-induced activation of AP-1, such as 46, 47, 48, 49and 51(Table 1).
Negative_regulation (inhibitors) of Positive_regulation (activation) of AP-1
10) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Assay of the activities of substituted trans-stilbeness as inhibitors of the TPA-induced activation of AP-1
Negative_regulation (inhibitors) of Positive_regulation (activation) of AP-1
11) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Anti-oxidant activities of enhancers and inhibitors of TPA-induced activation of AP-1
Negative_regulation (inhibitors) of Positive_regulation (activation) of AP-1
12) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.17 Pain Relevance 0.08
Inhibition or enhancement of the TPA-induced activation of AP-1 by analogs of trans-stilbenes
Negative_regulation (Inhibition) of Positive_regulation (activation) of AP-1
13) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Inhibition or enhancement of the TPA-induced activation of AP-1 by resveratrol and phenolic trans-stilbenes
Negative_regulation (Inhibition) of Positive_regulation (activation) of AP-1
14) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
Some of the compounds were strong inhibitors of the activation of AP-1.
Negative_regulation (inhibitors) of Positive_regulation (activation) of AP-1
15) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0 Pain Relevance 0
CPS itself does not affect the DNA-binding ability of NF-kappaB but it prevents IkappaB kinase activation and IkappaBalpha degradation in a dose-dependent manner, without inhibiting the activation of the mitogen-activated protein kinases, p38, extracellular regulated kinase and c-Jun N-terminal protein kinase.
Negative_regulation (inhibiting) of Positive_regulation (activation) of c-Jun associated with qutenza
16) Confidence 0.41 Published 2002 Journal Eur. J. Immunol. Section Abstract Doc Link 12115659 Disease Relevance 0.25 Pain Relevance 0.49
NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2.
Negative_regulation (suppress) of Positive_regulation (induced) of activator protein 1 associated with cox2
17) Confidence 0.41 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12433932 Disease Relevance 0.16 Pain Relevance 0.21
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Negative_regulation (diminished) of Positive_regulation (induced) of AP-1
18) Confidence 0.40 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis.
Negative_regulation (suppresses) of Positive_regulation (activation) of AP-1 in epidermis associated with qutenza
19) Confidence 0.37 Published 2001 Journal Cancer Lett. Section Title Doc Link 11179825 Disease Relevance 0.19 Pain Relevance 0.70
Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment.
Negative_regulation (abolished) of Positive_regulation (activation) of AP-1 associated with qutenza
20) Confidence 0.36 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.17 Pain Relevance 0.59

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