INT935

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 124
Total Number 124
Disease Relevance 35.72
Pain Relevance 43.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
pituitary 7
hypothalamus 5
anterior pituitary 5
nucleus 4
brain 4
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 63 100.00 Very High Very High Very High
cytokine 60 100.00 Very High Very High Very High
Neuropeptide 43 100.00 Very High Very High Very High
Opioid 38 100.00 Very High Very High Very High
Nerve growth factor 30 100.00 Very High Very High Very High
substance P 26 100.00 Very High Very High Very High
Somatostatin 22 100.00 Very High Very High Very High
c fibre 8 100.00 Very High Very High Very High
bradykinin 4 100.00 Very High Very High Very High
Enkephalin 35 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 45 100.00 Very High Very High Very High
Natriuresis 23 100.00 Very High Very High Very High
Cancer 23 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Hypotension 4 100.00 Very High Very High Very High
Hepatocellular Cancer 4 100.00 Very High Very High Very High
Retinoblastoma 3 100.00 Very High Very High Very High
Diabetes Mellitus 113 99.84 Very High Very High Very High
Apoptosis 132 99.80 Very High Very High Very High
Injury 60 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that intrathecal administration of substance P produces a neurally mediated increase in arterial pressure and heart rate and induces the release of an adrenal opioid factor which slows the neurally-mediated cardioacceleration by an action in the periphery.
Localization (release) of factor in heart associated with opioid, substance p and intrathecal
1) Confidence 0.70 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7510372 Disease Relevance 0.05 Pain Relevance 0.76
Hypophysectomy, but not adrenalectomy, decreased (relative to sham-operated controls) the swelling and Evans blue dye extravasation responses of the anesthetized rat's pawskin to thermal injury. alpha-Helical CRF (9-41), a synthetic competitive antagonist of corticotropin-releasing factor (CRF) on isolated pituitary cells, did not affect in sham-operated rats the swelling response after immersion of the paw in 58 degrees C water for 30 s.
Localization (releasing) of factor in paw associated with pressure and volume under development, antagonist and injury
2) Confidence 0.61 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1970186 Disease Relevance 0.52 Pain Relevance 0.24
Decreased inflammatory responsiveness of hypophysectomized rats to heat is reversed by a corticotropin-releasing factor (CRF) antagonist.
Localization (releasing) of factor associated with inflammation and antagonist
3) Confidence 0.61 Published 1990 Journal Regul. Pept. Section Title Doc Link 1970186 Disease Relevance 0.52 Pain Relevance 0.30
At T9 in adrenalectomized animals and at T2 in intact animals, the cardioacceleration was more abrupt than in intact animals injected at T9 suggesting that the adrenals are not necessary for the cardiovascular responses and that the adrenals may have released a factor which slows the neurally mediated cardioacceleration.
Localization (released) of factor
4) Confidence 0.61 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7510372 Disease Relevance 0.09 Pain Relevance 0.56
Finally, microdialysis sampling has demonstrated in vivo elevation of glial cell line-derived neurotrophic factor following grafting of primed fetal human neural stem cells into brain-injured rats, the first in vivo demonstration of the release of a neurotrophic factor by grafted stem cells.
Localization (release) of factor in brain
5) Confidence 0.58 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18436292 Disease Relevance 0.40 Pain Relevance 0.38
The aim of study was to investigate a contribution of hypothalamic-pituitary-adrenocortical (HPA) axis and opioid system in corticotrophin-releasing factor (CRF)-induced analgesic effect in conscious rats during thermal stimulus.
Localization (releasing) of factor in pituitary associated with analgesic and opioid
6) Confidence 0.55 Published 2010 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 20432720 Disease Relevance 0 Pain Relevance 0.75
Rats were prepared with a cannula implanted above the lateral cerebral ventricle, or bilateral cannulae above the hypothalamic paraventricular nuclei (PVN), the site of the perikarya of corticotropin-releasing factor (CRF)-secreting neurons regulating adrenocortical secretion.
Localization (secreting) of factor in ventricle
7) Confidence 0.53 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8510803 Disease Relevance 0 Pain Relevance 0.23
[Mechanisms of corticotropin-releasing factor-induced analgesic effect in conscious rats].
Localization (releasing) of factor associated with pain and analgesic
8) Confidence 0.52 Published 2010 Journal Ross Fiziol Zh Im I M Sechenova Section Title Doc Link 20432720 Disease Relevance 0 Pain Relevance 1.32
The colonic transit was accelerated by 5-HT (10 mg/kg, s.c.), 2-methyl-5-HT (30 mg/kg, s.c.), neostigmine (0.03-0.1 mg/kg, s.c.), corticotropin releasing factor (CRF; 1 microgram intracerebroventricular administration) and restraint stress (for 45 minutes).
Localization (releasing) of factor associated with stress and intracerebroventricular
9) Confidence 0.48 Published 1995 Journal Obes. Res. Section Abstract Doc Link 8653566 Disease Relevance 0.23 Pain Relevance 0.19
Two kappa agonists, fedotozine and trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolydinyl)-cyclohexyl ]- benzeneacetamide methanesulfonate [(+/-)U-50,488H] were used to reverse the gastrointestinal transit inhibition induced by either peritoneal irritation (PI) or intracisternal (i.c.) administration of corticotropin releasing factor (CRF).
Localization (releasing) of factor associated with agonist
10) Confidence 0.48 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932195 Disease Relevance 0.07 Pain Relevance 0.09
Corticotropin releasing factor (CRF) has a peripheral site of action for antinociception.
Localization (releasing) of factor associated with antinociception and analgesic
11) Confidence 0.41 Published 1989 Journal Eur. J. Pharmacol. Section Title Doc Link 2620699 Disease Relevance 0.80 Pain Relevance 0.72
One, the 5-HT1a receptor, releases a growth factor from astroglial cells.
Localization (releases) of factor
12) Confidence 0.39 Published 1992 Journal Brain Res. Section Abstract Doc Link 1535269 Disease Relevance 0.07 Pain Relevance 0.32
These results suggest that enhanced responsiveness of arteries from diabetic animals to alpha-adrenoceptor stimulation is not the result of a decrease in endothelium-derived relaxing factor (EDRF) release in diabetic blood vessels.
Localization (release) of factor in blood vessels associated with diabetes mellitus
13) Confidence 0.32 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2850927 Disease Relevance 0.79 Pain Relevance 0.26
Tripeptide growth factor, glycyl-L-histidyl-L-lysine (GHK), was employed as a ligand for activation or attachment of cells from a rat hepatoma cell line, H4-H-E-C3, and immobilized at the terminus of the dendrimer (GHK-dendrimer) to develop a suitable surface for use as a culture substratum in the bioartificial liver support system (BAL).
Localization (immobilized) of factor in liver associated with hepatocellular cancer
14) Confidence 0.31 Published 1999 Journal J. Biosci. Bioeng. Section Abstract Doc Link 16232640 Disease Relevance 0.29 Pain Relevance 0.08
The heart has an endocrine activity which depends on the secretion of a natriuretic, diuretic and hypotensive factor contained in osmophilic, secretory granules localized in the myocardiocytes and called "atrial specific granules" (the atrial natriuretic factor, ANF).
Localization (secretion) of factor in heart associated with natriuresis and hypotension
15) Confidence 0.29 Published 1993 Journal Medicina (B Aires) Section Abstract Doc Link 8084246 Disease Relevance 0.58 Pain Relevance 0.06
Corticotropin releasing factor (CRF) injected intracerebroventricularly in doses from 15-150 pmoles (10-1000 nanograms) produced a prolonged locomotor activation in rats previously habituated to a test cage environment.
Localization (releasing) of factor
16) Confidence 0.29 Published 1985 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 3878524 Disease Relevance 0.05 Pain Relevance 0.15
Stimulant and anxiogenic effects of corticotropin releasing factor.
Localization (releasing) of factor associated with narcan
17) Confidence 0.29 Published 1985 Journal Prog. Clin. Biol. Res. Section Title Doc Link 3878524 Disease Relevance 0.07 Pain Relevance 0.26
Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor.
Localization (releasing) of factor in visceral associated with hyperalgesia and nociceptor
18) Confidence 0.29 Published 2007 Journal Neurogastroenterol. Motil. Section Title Doc Link 17640185 Disease Relevance 0.19 Pain Relevance 0.31
Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor.
Localization (release) of factor
19) Confidence 0.24 Published 1981 Journal Agents Actions Section Abstract Doc Link 6280466 Disease Relevance 0.36 Pain Relevance 0.35
Clonidine prevents corticotropin releasing factor-induced epileptogenic activity in rats.
Localization (releasing) of factor associated with clonidine
20) Confidence 0.23 Published 1992 Journal Epilepsia Section Title Doc Link 1592016 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox