INT93503

Context Info Confidence 0.69 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 6 Disease Relevance 6.22 Pain Relevance 0.45

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2) DNA binding (Erbb2) cytoplasm (Erbb2)

Anatomy Link Frequency spinal cord 2 Erbb2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 3 100.00 Pain 5 85.72 cytokine 2 75.00 intrathecal 1 63.28 withdrawal 1 54.88 central sensitization 1 28.32 Lasting pain 1 25.00 nociceptor 1 25.00 medulla 8 17.48 headache 4 5.00

Disease Link Frequency Relevance Heat Breast Cancer 21 99.84 Malignant Neoplastic Disease 144 98.68 Recurrence 8 98.14 Cancer 99 97.96 Pheochromocytoma 204 97.80 Prostate Cancer 12 97.52 Paraganglioma 56 95.48 Glioblastoma 8 90.72 Phyllodes Tumor 2 84.24 Pain 2 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpression of ERBB-2 was more frequently detected in malignant than benign pheochromocytomas by multiplex ligation-dependent probe amplification and immunohistochemistry To analyze the genetic alterations of pheochromocytomas and evaluate the difference among malignant, extra-adrenal, and benign pheochromocytomas.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ERBB-2 associated with malignant neoplastic disease and pheochromocytoma

1) Confidence 0.69 Published 2008 Journal Endocrine-Related Cancer Section Title Doc Link PMC2254511 Disease Relevance 1.18 Pain Relevance 0

Overexpression of the ERBB-2, a breast cancer marker, is associated with rapid tumor growth, increased risk of recurrence after surgery, poor response to conventional chemotherapy, and shortened survival, and this ERBB-2 overexpression has also been implicated in the neoplastic transformation of prostate cancer (Ross & Fletcher 1998, Yu et al. 1998).

Positive_regulation (overexpression) of Gene_expression (overexpression) of ERBB-2 associated with cancer, breast cancer, prostate cancer and recurrence

2) Confidence 0.50 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2254511 Disease Relevance 1.24 Pain Relevance 0

Overexpression of the ERBB-2, a breast cancer marker, is associated with rapid tumor growth, increased risk of recurrence after surgery, poor response to conventional chemotherapy, and shortened survival, and this ERBB-2 overexpression has also been implicated in the neoplastic transformation of prostate cancer (Ross & Fletcher 1998, Yu et al. 1998).

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ERBB-2 associated with cancer, breast cancer, prostate cancer and recurrence

3) Confidence 0.50 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2254511 Disease Relevance 1.14 Pain Relevance 0

The overexpression of ERBB-2 identified by IHC suggested that this oncogene could be associated with the malignancy of pheochromocytomas and paragangliomas.

Positive_regulation (overexpression) of Gene_expression (overexpression) of ERBB-2 associated with malignant neoplastic disease, paraganglioma and pheochromocytoma

4) Confidence 0.46 Published 2008 Journal Endocrine-Related Cancer Section Abstract Doc Link PMC2254511 Disease Relevance 1.49 Pain Relevance 0

We observed that expression of NRG1 mRNA and the neuregulin receptors, ErbB2 and ErbB4 in the lumbar spinal cord was facilitated by the presence of progesterone in female rats following L5 nerve root ligation.

Positive_regulation (facilitated) of Gene_expression (expression) of ErbB2 in spinal cord associated with spinal cord

5) Confidence 0.41 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17459743 Disease Relevance 0.07 Pain Relevance 0.39

Positive p53 nuclear immunoreaction but negative c-erbB-2 overexpression by immunohistochemical staining was observed in this tumor.

Positive_regulation (overexpression) of Gene_expression (overexpression) of c-erbB-2 associated with cancer

6) Confidence 0.03 Published 2001 Journal Breast Cancer Section Abstract Doc Link 11180771 Disease Relevance 1.10 Pain Relevance 0.06

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