INT93505

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
melanocytes 2
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 18 100.00 Very High Very High Very High
agonist 2 66.12 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 4 75.00 Quite High
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In D10 cells, however, up-regulation could not be reproduced in vivo, suggesting that MC1R up-regulation is more dependent on the physiological environment.
Positive_regulation (dependent) of Positive_regulation (up-regulation) of MC1R associated with melanocortin 1 receptor
1) Confidence 0.70 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503610 Disease Relevance 0.33 Pain Relevance 0.87
E(+)/E(+) melanocytes express the wild-type melanocortin 1 receptor, e/e melanocytes express a loss-of-function mutation in the melanocortin 1 receptor that results in a yellow coat color, and E(so)/E(so) is a mutation that causes constitutive activation of the melanocortin 1 receptor and renders melanocytes unresponsive to (alpha)-melanocyte stimulating hormone.
Positive_regulation (causes) of Positive_regulation (activation) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
2) Confidence 0.43 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.59

General Comments

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