INT93527

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Context Info
Confidence 0.28
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
glomerulus 4
sympathetic 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 69.60 Quite High
antagonist 7 53.76 Quite High
cOX1 2 42.80 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 3 93.08 High High
Targeted Disruption 3 90.84 High High
Chronic Renal Failure 64 85.92 High High
Diuresis 2 79.32 Quite High
Natriuresis 2 78.80 Quite High
Disease 10 76.12 Quite High
Stress 3 70.24 Quite High
INFLAMMATION 4 68.16 Quite High
Death 6 40.28 Quite Low
Cv Unclassified Under Development 18 26.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renin is stored in secretory granules and is released in response to decreases in renal perfusion pressure, decreases in Cl- in the distal tubule fluid or increased sympathetic nerve stimulation via ?
Positive_regulation (response) of Localization (released) of Renin in sympathetic
1) Confidence 0.28 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.37 Pain Relevance 0
In contrast, EP4 receptor mRNA is predominantly expressed in the glomerulus, where it may contribute to the regulation of glomerular hemodynamics and renin release.
Spec (may) Positive_regulation (contribute) of Localization (release) of renin in glomerulus
2) Confidence 0.15 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.11
The IP receptor mRNA is highly expressed near the glomerulus, in the afferent arteriole, where it may also dilate renal arterioles and stimulate renin release.
Positive_regulation (stimulate) of Localization (release) of renin in glomerulus
3) Confidence 0.15 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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