INT93530

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 0.54
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
Granulosa cells 2
thalamus 2
dorsal root ganglia 2
parietal cortex 1
limb 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 12 99.24 Very High Very High Very High
alcohol 15 84.48 Quite High
cOX1 1 70.96 Quite High
cerebral cortex 6 56.24 Quite High
Hippocampus 48 54.88 Quite High
midbrain 6 53.04 Quite High
agonist 39 51.12 Quite High
long-term potentiation 174 31.48 Quite Low
antagonist 4 25.00 Low Low
cINOD 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 1 94.56 High High
Diuresis 1 93.92 High High
Targeted Disruption 103 65.68 Quite High
Hypertension 7 60.64 Quite High
Stress 7 57.24 Quite High
INFLAMMATION 1 25.00 Low Low
Fever 18 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Granulosa cells from human follicular aspirates were reported to express mRNA for EP2 and EP4, while EP1 and EP3 mRNA were not detected [31].
Neg (not) Transcription (detected) of EP1 in Granulosa cells
1) Confidence 0.42 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
In contrast, EP1 mRNA was not detected in any mouse oocyte preparation examined (n = 3).
Neg (not) Transcription (detected) of EP1 in oocyte
2) Confidence 0.42 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.04
EP1 and EP3 mRNA expression predominates in the collecting duct and thick limb, respectively, where their stimulation reduces NaCl and water absorption, promoting natriuresis and diuresis.
Transcription (expression) of EP1 in limb associated with diuresis and natriuresis
3) Confidence 0.35 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.31 Pain Relevance 0.04
These discrepancies are reminiscent of our studies of EP expression in monkey mural granulosa cells before administration of the ovulatory gonadotropin stimulus, when EP1 and EP4 mRNA were detected, but these EP proteins were not detected by immunofluorescence [8].
Transcription (detected) of EP1 in granulosa cells
4) Confidence 0.31 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.05
However, a recent study showed that the levels of EP1 mRNA are the highest in the parietal cortex and cerebellum and that the protein level of EP1 is high in cerebellum (Candelario-Jalil et al. 2005).
Transcription (levels) of EP1 in cerebellum
5) Confidence 0.31 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.16
Although EP1 mRNA is distributed mainly in the kidneys, lungs, and stomach, EP1 is also found in the neurons in thalamus and dorsal root ganglia (DRG) (Watabe et al. 1993).
Transcription (distributed) of EP1 in thalamus associated with thalamus
6) Confidence 0.30 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.06 Pain Relevance 0.05
Although EP1 mRNA is distributed mainly in the kidneys, lungs, and stomach, EP1 is also found in the neurons in thalamus and dorsal root ganglia (DRG) (Watabe et al. 1993).
Transcription (found) of EP1 in thalamus associated with thalamus
7) Confidence 0.30 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.05 Pain Relevance 0.05
However, a recent study showed that the levels of EP1 mRNA are the highest in the parietal cortex and cerebellum and that the protein level of EP1 is high in cerebellum (Candelario-Jalil et al. 2005).
Transcription (levels) of EP1 in parietal cortex
8) Confidence 0.10 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.16
Although EP1 mRNA is distributed mainly in the kidneys, lungs, and stomach, EP1 is also found in the neurons in thalamus and dorsal root ganglia (DRG) (Watabe et al. 1993).
Transcription (found) of EP1 in dorsal root ganglia associated with thalamus
9) Confidence 0.10 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.05 Pain Relevance 0.05
Although EP1 mRNA is distributed mainly in the kidneys, lungs, and stomach, EP1 is also found in the neurons in thalamus and dorsal root ganglia (DRG) (Watabe et al. 1993).
Transcription (distributed) of EP1 in dorsal root ganglia associated with thalamus
10) Confidence 0.10 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.06 Pain Relevance 0.05

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