INT93534

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 185
Total Number 188
Disease Relevance 119.26
Pain Relevance 33.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoclast 24
osteoblasts 19
T cells 16
joints 8
stromal cells 6
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2270 100.00 Very High Very High Very High
cytokine 1971 100.00 Very High Very High Very High
antagonist 213 100.00 Very High Very High Very High
rheumatoid arthritis 2454 99.96 Very High Very High Very High
Infliximab 26 99.74 Very High Very High Very High
dexamethasone 5 99.62 Very High Very High Very High
withdrawal 17 99.32 Very High Very High Very High
methotrexate 26 99.14 Very High Very High Very High
Arthritis 1942 99.02 Very High Very High Very High
Snapping jaw 36 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2332 100.00 Very High Very High Very High
Rheumatoid Arthritis 2454 99.96 Very High Very High Very High
Hypercalcemia 1659 99.96 Very High Very High Very High
Bone Cancer 298 99.96 Very High Very High Very High
Cancer 1133 99.84 Very High Very High Very High
Reprotox - General 1 92 99.84 Very High Very High Very High
Osteoporosis 1413 99.80 Very High Very High Very High
Breast Cancer 188 99.66 Very High Very High Very High
Osteolysis 251 99.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 228 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The expressions of RANKL mRNA and protein in synovial cells were increased with compressive force.
Gene_expression (expressions) of RANKL mRNA in synovial cells
1) Confidence 0.77 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17321443 Disease Relevance 0.08 Pain Relevance 0
Compressive mechanical stress promotes osteoclast formation through RANKL expression on synovial cells.
Gene_expression (expression) of RANKL in synovial cells associated with stress
2) Confidence 0.77 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 17321443 Disease Relevance 0.20 Pain Relevance 0.09
CONCLUSION: Our results indicated that the expression of RANKL in compressed synovial cells enhanced osteoclast formation, whereas continuous compressive force may induce osteoclastic bone destruction in the TMJ.


Gene_expression (expression) of RANKL in TMJ
3) Confidence 0.77 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 17321443 Disease Relevance 0.06 Pain Relevance 0
Expression of osteoprotegerin in synovial tissue and degradation of articular cartilage: comparison with arthroscopic findings of temporomandibular joint disorders.
Gene_expression (Expression) of osteoprotegerin in articular cartilage associated with snapping jaw
4) Confidence 0.77 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 12973279 Disease Relevance 0.52 Pain Relevance 0.42
Both ST2 and MC3T3-E1 cells showed similar levels of increased RANKL protein expression at 1, 2, and 3 days after the addition of MIP-1alpha.
Gene_expression (expression) of RANKL protein in MC3T3-E1
5) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.27 Pain Relevance 0.10
RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner.
Gene_expression (expressions) of RANKL mRNA in MC3T3-E1
6) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.31 Pain Relevance 0.11
In the present study, our group investigated the mechanism by which RANKL expression is induced by MIP-1alpha and the effects of MIP-1alpha on the activation of osteoclasts.
Gene_expression (expression) of RANKL in osteoclasts
7) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.33 Pain Relevance 0.12
RANKL mRNA expression began to increase at 1 h after the addition of MIP-1alpha; the increase became remarkable at 2 h, and continuous expression was observed subsequently.
Gene_expression (expression) of RANKL mRNA
8) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.30 Pain Relevance 0.11
When SB203580, a p38MAPK inhibitor, was added, RANKL mRNA and RANKL protein expression were increased in these cells.
Gene_expression (expression) of RANKL protein
9) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.45 Pain Relevance 0.04
Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways.
Gene_expression (expression) of RANKL in bone marrow associated with inflammation
10) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Title Doc Link 17549607 Disease Relevance 0.36 Pain Relevance 0.14
RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner.
Gene_expression (expressions) of RANKL protein in MC3T3-E1
11) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.31 Pain Relevance 0.11
This substance also indirectly induces osteoclastic differentiation through the promotion of RANKL expression in bone-marrow stromal cells and osteoblasts.
Gene_expression (expression) of RANKL in osteoblasts associated with osteoporosis
12) Confidence 0.77 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.53 Pain Relevance 0.04
RANKL is produced by prostate cancer bone metastases, enabling these metastases to induce osteolysis through osteoclast activation.
Gene_expression (produced) of RANKL in osteoclast associated with osteolysis, metastasis and reprotox - general 1
13) Confidence 0.75 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532187 Disease Relevance 1.93 Pain Relevance 0.11
Osteoprotegerin is produced when prostaglandin synthesis is inhibited causing osteoclasts to detach from the surface of mouse parietal bone and attach to the endocranial membrane.
Gene_expression (produced) of Osteoprotegerin in osteoclasts
14) Confidence 0.73 Published 2001 Journal Bone Section Title Doc Link 11182380 Disease Relevance 0.23 Pain Relevance 0.09
Unlike most of the other mediators previously implicated in myeloma bone disease, RANKL is expressed in various cell types as a transmembrane protein, although it can be cleaved, as occurs in activated T cells, to yield a soluble form that remains biologically active.
Gene_expression (expressed) of RANKL in T cells associated with bone cancer
15) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.88 Pain Relevance 0.05
This, in turn, upregulates levels of expression of RANKL and interleukin-6, which further exacerbates bone destruction and increases tumor burden [30].
Gene_expression (expression) of RANKL associated with cancer
16) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.05 Pain Relevance 0.21
Interestingly, canonical Wnt signaling was recently shown to modulate RANKL and OPG expression in osteoblasts in vitro, resulting in inhibition of osteoclastogenesis [34].
Gene_expression (expression) of OPG in osteoblasts
17) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.99 Pain Relevance 0.11
Interestingly, canonical Wnt signaling was recently shown to modulate RANKL and OPG expression in osteoblasts in vitro, resulting in inhibition of osteoclastogenesis [34].
Gene_expression (expression) of RANKL in osteoblasts
18) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.99 Pain Relevance 0.11
RANKL, which is abundantly produced by osteoblasts, stimulates osteoclastic lineage commitment, promotes cellular maturation and functions, and prolongs survival, which together enhance bone resorption [3].
Gene_expression (produced) of RANKL in osteoblasts associated with hypercalcemia and osteoporosis
19) Confidence 0.72 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.30 Pain Relevance 0.09
The effects of RANKL are counter-balanced by the endogenous decoy receptor osteoprotegerin (OPG), also produced by osteoblasts [4].
Gene_expression (produced) of OPG in osteoblasts
20) Confidence 0.72 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.44 Pain Relevance 0.04

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