INT9354

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Context Info
Confidence 0.21
First Reported 1984
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.09
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
tolerance 5 100.00 Very High Very High Very High
analgesia 2 98.64 Very High Very High Very High
opioid receptor 3 97.60 Very High Very High Very High
Dynorphin 1 97.28 Very High Very High Very High
Intracerebroventricular 1 96.96 Very High Very High Very High
narcan 1 92.24 High High
agonist 3 87.88 High High
mu opioid receptor 3 85.92 High High
Analgesic 5 84.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral treatment with oxytocin blocked the development of heroin-enkephalin cross-tolerance.
Negative_regulation (blocked) of heroin-enkephalin Binding (cross-tolerance) of associated with tolerance and enkephalin
1) Confidence 0.21 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1409803 Disease Relevance 0.09 Pain Relevance 0.89
This crossreactivity could be blocked following pre-absorption with the appropriate enkephalin, but not by pre-absorption with synthetic beta-endorphin (1-31) or dynorphin (1-13).
Negative_regulation (blocked) of enkephalin Binding (pre-absorption) of associated with dynorphin and enkephalin
2) Confidence 0.06 Published 1984 Journal Cell Tissue Res. Section Abstract Doc Link 6321029 Disease Relevance 0 Pain Relevance 0.53
They also inhibited the binding of [3H]DPDPE ([D-Pen(2),D-Pen(5)]enkephalin) and [3H]DAGO ([D-Ala(2),Mephe(4),Gly-ol(5)]enkephalin) to opioid receptors in mouse brain membranes.
Negative_regulation (inhibited) of enkephalin Binding (binding) of in brain associated with opioid receptor and enkephalin
3) Confidence 0.03 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11672562 Disease Relevance 0 Pain Relevance 0.88

General Comments

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