INT9355

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1982
Last Reported 2009
Negated 9
Speculated 2
Reported most in Abstract
Documents 81
Total Number 84
Disease Relevance 10.41
Pain Relevance 24.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 8
spinal 2
pituitary 2
radial 1
gland 1
pcp (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 41 100.00 Very High Very High Very High
Morphine 34 100.00 Very High Very High Very High
fortral 32 100.00 Very High Very High Very High
Clonidine 1 100.00 Very High Very High Very High
MU agonist 11 99.96 Very High Very High Very High
antinociception 4 99.92 Very High Very High Very High
opiate 47 99.86 Very High Very High Very High
dopamine receptor 16 99.84 Very High Very High Very High
local anesthetic 12 99.84 Very High Very High Very High
Dopamine 30 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pneumocystis Pneumonia 168 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 99.98 Very High Very High Very High
Gastritis 5 99.44 Very High Very High Very High
Schizophrenia 2 99.24 Very High Very High Very High
Substance Withdrawal Syndrome 2 99.04 Very High Very High Very High
Nociception 12 98.96 Very High Very High Very High
Ataxia 4 98.64 Very High Very High Very High
Drug Induced Neurotoxicity 5 98.60 Very High Very High Very High
Systemic Lupus Erythematosus 18 98.56 Very High Very High Very High
Polyps 5 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of mice for 1, 7, 14, and 21 days with PCP (10 mg.kg-1.day-1) failed to induce variations in sigma p, sigma h, and PCP receptor binding.
PCP receptor Binding (binding) of
1) Confidence 0.46 Published 1989 Journal FASEB J. Section Abstract Doc Link 2541039 Disease Relevance 0 Pain Relevance 0.25
Among their many pharmacological actions, drugs which bind to the PCP receptor antagonize the actions of glutamic acid mediated via the NMDA excitatory amino acid receptor, leading to their potential use as anti-ischemic and anticonvulsant agents.
PCP Binding (bind) of associated with anticonvulsant and excitatory amino acid
2) Confidence 0.41 Published 1988 Journal Neuropeptides Section Abstract Doc Link 2843788 Disease Relevance 0 Pain Relevance 0.74
The PCP-induced decrease in MAC was not altered by naloxone treatment indicating that an interaction of PCP with opiate mechanisms is unlikely.
PCP Binding (interaction) of associated with narcan and opiate
3) Confidence 0.40 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6802034 Disease Relevance 0 Pain Relevance 0.37
Effects of drugs that bind to PCP and sigma receptors on punished responding.
PCP Binding (bind) of
4) Confidence 0.40 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1653832 Disease Relevance 0 Pain Relevance 0.17
There was a high correlation (0.95) between the relative potency of these drugs in increasing punished responding and their relative affinity for PCP receptors.
PCP Binding (affinity) of associated with potency
5) Confidence 0.40 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1653832 Disease Relevance 0 Pain Relevance 0.20
PCP had no effect on the kinetic properties of IK and the block failed to show use dependency, suggesting that PCP may bind to the IK channel via a hydrophobic mechanism not requiring open channels.
PCP Neg (not) Binding (bind) of
6) Confidence 0.40 Published 1989 Journal J. Neurosci. Section Abstract Doc Link 2555461 Disease Relevance 0 Pain Relevance 0.15
However, similar treatment with haloperidol (4 mg.kg-1.day-1) induced: 1) complete elimination of the binding to sigma h sites, 2) up-regulation of D-2 dopamine receptors, and 3) no change in sigma p and PCP receptor binding after 14 or 21 days of treatment.
PCP receptor Binding (binding) of associated with dopamine receptor
7) Confidence 0.40 Published 1989 Journal FASEB J. Section Abstract Doc Link 2541039 Disease Relevance 0 Pain Relevance 0.21
However, the psychotomimetic effects induced by PCP are believed to be mediated by specific PCP receptors, where PCP binds with greater potency than sigma compounds.
PCP Binding (mediated) of associated with potency
8) Confidence 0.37 Published 1987 Journal Mol. Neurobiol. Section Abstract Doc Link 2855791 Disease Relevance 0 Pain Relevance 0.36
However, the psychotomimetic effects induced by PCP are believed to be mediated by specific PCP receptors, where PCP binds with greater potency than sigma compounds.
PCP Binding (binds) of associated with potency
9) Confidence 0.37 Published 1987 Journal Mol. Neurobiol. Section Abstract Doc Link 2855791 Disease Relevance 0 Pain Relevance 0.36
They do, however, demonstrate that sigma-ligands with little to no affinity for PCP receptors are capable of antagonizing the (+)NANM stimulus.
PCP Neg (no) Binding (affinity) of
10) Confidence 0.37 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8105490 Disease Relevance 0 Pain Relevance 0.10
The present results neither establish a role for sigma involvement in the stimulus properties of (+)NANM nor eliminate a role for PCP receptors.
PCP Neg (neither) Binding (role) of
11) Confidence 0.37 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8105490 Disease Relevance 0 Pain Relevance 0.11
PCP also interacts with sigma, mu opioid, muscarinic, and nicotinic receptors.
PCP Binding (interacts) of associated with opioid
12) Confidence 0.36 Published 1987 Journal Mol. Neurobiol. Section Abstract Doc Link 2855791 Disease Relevance 0 Pain Relevance 0.36
Recently, however, there have been several reports demonstrating significant differences between the binding of PCP and SKF 10,047, a sigma opioid agonist, which suggests that there may be distinct PCP and sigma opioid receptors.
PCP Binding (binding) of associated with mu agonist and opioid receptor
13) Confidence 0.34 Published 1987 Journal Synapse Section Abstract Doc Link 2850620 Disease Relevance 0 Pain Relevance 0.32
Is this reflective of new developments in palliative care and chemotherapy regimens being given among younger patients, particularly when they are first admitted to the PCP?
PCP Binding (admitted) of associated with palliative
14) Confidence 0.32 Published 2006 Journal BMC Palliat Care Section Body Doc Link PMC1557663 Disease Relevance 0.55 Pain Relevance 0.10
Animals sensitized to the effects of either d- or l-NAN exhibited cross-sensitization to PCP.
PCP Binding (cross-sensitization) of
15) Confidence 0.32 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3088640 Disease Relevance 0.09 Pain Relevance 0.60
Mice were used for a study of the interaction between morphine and phencyclidine (PCP) in relation to lethality, motor incoordination, locomotor activity and rearing, together with the half-life of PCP, following continuous administration of morphine by pellet (75 mg base) implantation for 72 h and after removal of the pellets for 6 and 24 h.
PCP Binding (interaction) of associated with ataxia, eae and morphine
16) Confidence 0.31 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6499921 Disease Relevance 0.18 Pain Relevance 0.66
Inhibition of specific binding of tritiated PCP, morphine, or quinuclidinyl benzylate (QNB) in rat brain homogenates was measured for these compounds.
PCP Binding (binding) of in brain associated with morphine
17) Confidence 0.31 Published 1982 Journal J. Med. Chem. Section Abstract Doc Link 6279847 Disease Relevance 0 Pain Relevance 0.16
The most characteristic effects of hydroxylation of PCP on the cyclohexyl, piperidine, or phenyl moieties are the following: (i) it generally decreases its activity in inhibiting [3H]PCP binding by a factor of 10 to 80; (ii) it does not produce a large variation in the affinity for the morphine receptor; (iii) it produces a considerable decrease of the affinity for the muscarinic receptor.
PCP Binding (binding) of associated with morphine
18) Confidence 0.31 Published 1982 Journal J. Med. Chem. Section Abstract Doc Link 6279847 Disease Relevance 0 Pain Relevance 0.29
Inhibition of PCP binding for selected compounds correlated with mouse rotarod assay activity.
PCP Binding (binding) of
19) Confidence 0.31 Published 1982 Journal J. Med. Chem. Section Abstract Doc Link 6279847 Disease Relevance 0 Pain Relevance 0.17
However, the psychotomimetic effects induced by PCP are believed to be mediated by specific PCP receptors, where PCP binds with greater potency than sigma compounds.
PCP Binding (binds) of associated with potency
20) Confidence 0.31 Published 1987 Journal Mol. Neurobiol. Section Abstract Doc Link 2855791 Disease Relevance 0 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox