INT93559

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.58
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbd) plasma membrane (Thbd) embryo development (Thbd)
molecular_function (Thbd)
Anatomy Link Frequency
plasma 1
endothelial cell 1
white blood cell 1
tail 1
alveolar macrophages 1
Thbd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 98.74 Very High Very High Very High
rheumatoid arthritis 6 98.60 Very High Very High Very High
Inflammation 20 95.16 Very High Very High Very High
cytokine 19 93.04 High High
Inflammatory response 16 89.00 High High
cva 137 75.00 Quite High
Percutaneous transluminal coronary angioplasty 1 59.88 Quite High
Bile 7 49.52 Quite Low
COX2 2 10.00 Low Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis Related Under Development 109 99.84 Very High Very High Very High
Adhesions 8 99.72 Very High Very High Very High
Injury 14 99.26 Very High Very High Very High
Rheumatoid Arthritis 6 98.60 Very High Very High Very High
Cancer 129 98.58 Very High Very High Very High
Thrombosis 28 98.14 Very High Very High Very High
INFLAMMATION 37 95.16 Very High Very High Very High
Autoimmune Disease 2 94.64 High High
Stroke 205 93.24 High High
Adenocarcinoma 5 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are needed to determine whether this association is due to population stratification, linkage to a nearby functional polymorphism, or variation in thrombomodulin expression or function.


Gene_expression (expression) of thrombomodulin
1) Confidence 0.75 Published 2004 Journal BMC Neurol Section Body Doc Link PMC538749 Disease Relevance 0.26 Pain Relevance 0
The thrombomodulin protein is expressed primarily on the luminal surface of vascular endothelial cells and consists of 557 amino acids (aa) (60,300 Dalton): an N-terminal lectin-like module (aa 1–154), a hydrophobic region (aa 155–222), six epidermal growth factor (EGF)-like modules (aa 223–462), a serine and threonine rich region (aa 463–497), a single transmembrane segment (aa 498–521), and a short cytoplasmic tail (aa 522–557) [6].
Gene_expression (expressed) of thrombomodulin protein in tail
2) Confidence 0.58 Published 2004 Journal BMC Neurol Section Body Doc Link PMC538749 Disease Relevance 0.56 Pain Relevance 0.08
Further studies are needed to determine whether this polymorphism is functionally related to thrombomodulin expression or whether the association is due to population stratification or linkage to a nearby functional polymorphism.



Gene_expression (expression) of thrombomodulin
3) Confidence 0.58 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC538749 Disease Relevance 0.74 Pain Relevance 0.04
Furthermore, two polymorphisms close to the Ala455Val polymorphism, Arg385Ser and Pro477Ser, have been shown to influence the expression and function of thrombomodulin in a tissue culture model [23].


Gene_expression (expression) of thrombomodulin
4) Confidence 0.58 Published 2004 Journal BMC Neurol Section Body Doc Link PMC538749 Disease Relevance 0.35 Pain Relevance 0
Decrease in circulating endothelial cell adhesion molecule and thrombomodulin levels during oral iloprost treatment in rheumatoid arthritis patients: preliminary results.
Gene_expression (levels) of thrombomodulin in endothelial cell associated with pain, rheumatoid arthritis and adhesions
5) Confidence 0.21 Published 2006 Journal Rheumatol. Int. Section Title Doc Link 15700117 Disease Relevance 0.65 Pain Relevance 0.41
METHODS: Plasma thrombomodulin levels and the values of the plasma adhesion molecules VCAM-1 (vascular cell adhesion molecule 1), E-selectin (CD62E), and ICAM-1 (intercellular adhesion molecule 1, CD 54) were measured by ELISA during a 7-day period of treatment with orally-administered iloprost in 14 patients with active rheumatoid arthritis.
Gene_expression (levels) of thrombomodulin in plasma
6) Confidence 0.21 Published 2006 Journal Rheumatol. Int. Section Body Doc Link 15700117 Disease Relevance 0.19 Pain Relevance 0
Bacterial LPS increases the expression of thrombomodulin in alveolar macrophages and this effect could enhance the activation of Protein C in the thrombin-thrombomodulin complex.
Gene_expression (expression) of thrombomodulin in alveolar macrophages
7) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 0.20 Pain Relevance 0
RESULTS: Naproxen suppressed biosynthesis of PGE-M, prostacyclin metabolites and thromboxane metabolites and thrombomodulin levels.
Gene_expression (biosynthesis) of thrombomodulin
8) Confidence 0.11 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
None of the coxibs exerted significant effects on the expression of platelet activation markers, cAMP generation, platelet-leukocyte formation, or on thrombomodulin plasma levels.
Gene_expression (expression) of thrombomodulin in platelet
9) Confidence 0.09 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
Arterial blood gases, pulmonary function, mean pulmonary arterial pressure, left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF), white blood cell count, C-reactive protein and the plasma concentrations of fibrinopeptide A, beta-thromboglobulin, platelet factor 4 and thrombomodulin were evaluated before and 2 and 12 months after SH administration.
Gene_expression (evaluated) of thrombomodulin in white blood cell
10) Confidence 0.07 Published 2000 Journal J. Int. Med. Res. Section Abstract Doc Link 11191719 Disease Relevance 0.64 Pain Relevance 0.08
In a rabbit stasis/injury model of arterial thrombosis, local overexpression of thrombomodulin using Ad was assessed.
Gene_expression (overexpression) of thrombomodulin associated with injury and thrombosis related under development
11) Confidence 0.06 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.98 Pain Relevance 0.08
Immunohistochemically, the tumour cells showed positivity for EMA, CEA, Ca125, and CK7 (fig 2) and were negative for CK20, PSA, PAP, calretinin, and thrombomodulin.
Neg (negative) Gene_expression (negative) of thrombomodulin associated with cancer
12) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2000863 Disease Relevance 1.02 Pain Relevance 0
promote thrombosis at the vascular wall by inducing endothelial expression of tissue factor and downregulating expression of thrombomodulin, the endothelial thrombin receptor that plays a key role in the activation of the anticoagulant protein C pathway.
Gene_expression (expression) of thrombomodulin associated with thrombosis
13) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496976 Disease Relevance 0.99 Pain Relevance 0.10

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