INT9356

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.26
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
nucleus accumbens 1
amygdala 1
hippocampus 1
frontal cortex 1
pcp (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 42 100.00 Very High Very High Very High
amygdala 32 100.00 Very High Very High Very High
Cancer pain 7 100.00 Very High Very High Very High
fortral 8 99.92 Very High Very High Very High
Morphine 5 99.58 Very High Very High Very High
narcan 3 99.50 Very High Very High Very High
Glutamate receptor 14 99.42 Very High Very High Very High
Dopamine 22 98.96 Very High Very High Very High
Pain 11 98.86 Very High Very High Very High
Delta-9-tetrahydrocannabinol 1 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
Schizophrenia 33 99.72 Very High Very High Very High
Adult Respiratory Distress Syndrome 25 99.40 Very High Very High Very High
Death 6 99.24 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 15 98.60 Very High Very High Very High
Pulmonary Hypertension 4 98.44 Very High Very High Very High
Urological Neuroanatomy 6 96.96 Very High Very High Very High
INFLAMMATION 3 93.64 High High
Anxiety Disorder 113 91.92 High High
Post-traumatic Stress Disorder 56 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice.
Regulation (regulation) of PCP
1) Confidence 0.58 Published 1989 Journal FASEB J. Section Title Doc Link 2541039 Disease Relevance 0 Pain Relevance 0.25
Other contrasts comparing male PCP-treated mice with male controls and female PCP-treated mice with female controls did not produce significant performance differences between the groups, on average across the blocks of trials, suggesting that there were no meaningful effects of PCP treatment as a function of Gender.
Neg (no) Regulation (effects) of PCP
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.06 Pain Relevance 0.03
As a result, the data from the two groups were combined and ANOVAs were conducted on the P2 PCP-treated mice and the combined control group in an effort to clarify the effects of PCP treatment on learning and memory.
Regulation (effects) of PCP
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.69 Pain Relevance 0.05
However, the lack of significant performance differences following comparisons conducted between the two male groups and between the two female groups suggested that there were no meaningful gender-based effects of PCP treatment.
Neg (no) Regulation (effects) of PCP
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0
As a result, the data from the two groups were combined and ANOVAs were conducted on the P2 PCP-treated mice and the combined control group in an effort to clarify the effects of PCP treatment on learning and memory.
Regulation (conducted) of PCP-treated
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.71 Pain Relevance 0.04
Analyses of the normal and deprived control groups again showed no significant differences on any learning and memory measures at any age (P30, P75, P170) so the data from the two groups were combined for statistical analyses conducted on the P2+P7 PCP-treated mice in an effort to simplify the interpretation of the effect of PCP treatment on learning and memory.
Regulation (effect) of PCP
6) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.29 Pain Relevance 0.08
After controlling for other potential predictors, involvement of the PCP was not a significant predictor of the total cost of the WRLBP claim.
Regulation (involvement) of PCP
7) Confidence 0.23 Published 2004 Journal Spine Section Body Doc Link 15105679 Disease Relevance 0 Pain Relevance 0
Because celiac pain was only a component of PCP in all patients, especially in those with a longer time course until death: 1) abolition of such pain did not ensure high percentages of complete pain relief (immediate pain relief in 40-52%; pain relief until death in 10-24%); 2) NCPB was effective in controlling PCP in a higher percentage of cases if performed early after pain onset, when the pain was still only or mainly of celiac type and responded well to nonsteroidal antiinflammatory drug therapy; and 3) the probability of patients remaining completely pain-free diminished with increased survival time.
Regulation (controlling) of PCP associated with pain, inflammation, cancer pain and death
8) Confidence 0.23 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1550278 Disease Relevance 1.95 Pain Relevance 1.40
In contrast, all divisions of the neocortex showed a high density of staining in mice exposed to PCP on P7 with the hippocampus, hypothalamus and amygdala being less prominently affected (Fig. 1).
Regulation (affected) of PCP in amygdala associated with hippocampus and amygdala
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.06 Pain Relevance 0.27
These results confirm previous research using pigeons that had shown antipunishment effects of PCP and provide further evidence for an overlap in the pharmacology of PCP-like drugs and depressant drugs such as barbiturates and benzodiazepines.
Regulation (effects) of PCP
10) Confidence 0.22 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2539469 Disease Relevance 0.08 Pain Relevance 0.30
Whereas, intravenous and intraventricular metaphit pretreatment failed to alter the locomotor stimulatory effects of PCP, direct injections of metaphit into the nucleus accumbens resulted in a dose-dependent reduction of PCP-induced hyperactivity.
Neg (failed) Regulation (alter) of PCP in nucleus accumbens associated with nucleus accumbens and attention deficit hyperactivity disorder
11) Confidence 0.21 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2820762 Disease Relevance 0.26 Pain Relevance 0.31
The present results clearly demonstrate the differential effects of PCP on cortical and striatal DA transmission, suggesting that PCP may facilitate DA release in the medial frontal cortex by increasing impulse flow in the DA neurons projecting to the cortical area, whereas PCP-induced elevation of extracellular DA in the striatum may be caused mainly by reuptake inhibition of DA liberated by basal activity of the striatal DA neurons.
Regulation (effects) of PCP in frontal cortex associated with dopamine and urological neuroanatomy
12) Confidence 0.17 Published 1996 Journal Synapse Section Abstract Doc Link 8867025 Disease Relevance 0.34 Pain Relevance 0.79
Physostigmine (0.1 mg/Kg i.v.), clonidine (0.1 mg/Kg i.v.), haloperidol (1 mg/Kg i.v.) and naloxone (10 mg/Kg i.v.) did not affect the inhibitory influence of PCP on epileptiform activity due to cortical application of penicillin.
Neg (not) Regulation (affect) of PCP associated with narcan and clonidine
13) Confidence 0.14 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 2996035 Disease Relevance 0.15 Pain Relevance 0.54
The study included: amphetamine, benzoylecgonine, 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH), morphine, and phencyclidine (PCP) as examples of the HHS regulated drug classes.
Regulation (regulated) of PCP associated with delta-9-tetrahydrocannabinol and morphine
14) Confidence 0.13 Published 1996 Journal J. Forensic Sci. Section Abstract Doc Link 8789844 Disease Relevance 0 Pain Relevance 0.23
Rats were used for comparing the behavioral response profiles of phencyclidine (PCP) and d,1-N-allylnormetazocine (NANM), two drugs that are proposed to exert their effects through the "PCP/sigma" receptor.
Regulation (effects) of PCP
15) Confidence 0.12 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3003779 Disease Relevance 0.08 Pain Relevance 0.33
In contrast, all divisions of the neocortex showed a high density of staining in mice exposed to PCP on P7 with the hippocampus, hypothalamus and amygdala being less prominently affected (Fig. 1).
Regulation (affected) of PCP in hippocampus associated with hippocampus and amygdala
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.06 Pain Relevance 0.27
In contrast, all divisions of the neocortex showed a high density of staining in mice exposed to PCP on P7 with the hippocampus, hypothalamus and amygdala being less prominently affected (Fig. 1).
Regulation (affected) of PCP in hypothalamus associated with hippocampus and amygdala
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.06 Pain Relevance 0.27
Assessment was made of the effects of PCP, MK-801, (+)-pentazocine, (+)- and (-)-N-allyl-normetazocine (NANM), (+)-amphetamine and BMY-14802 in rats responding under a multiple timeout 600 s (TO), differential reinforcement of low rates 10 s (DRL), fixed ratio (FR) 10 schedule of reinforcement.
Regulation (effects) of PCP associated with fortral
18) Confidence 0.05 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1410131 Disease Relevance 0 Pain Relevance 0.27
The ethanol-like discriminative stimulus effects of PCP, pentazocine and NANM, which are also sigma receptor ligands, are likely to be attributed to their activity at NMDA receptors.
Regulation (effects) of PCP associated with fortral and nmda receptor
19) Confidence 0.04 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9489933 Disease Relevance 0 Pain Relevance 0.59
The effect of LY404039 on PCP- or amphetamine-induced locomotor hyperactivity is absent in mGlu2 receptor- or mGlu2/3 receptor-null mice, but not in mGlu3 receptor-null mice [26].
Regulation (effect) of PCP associated with attention deficit hyperactivity disorder
20) Confidence 0.03 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 0.59 Pain Relevance 0.31

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