INT93562

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 1.87
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
reticulum 8
neuron 2
embryonic kidney 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 7 100.00 Very High Very High Very High
antagonist 24 99.52 Very High Very High Very High
Versed 129 98.08 Very High Very High Very High
Glutamate receptor 1 95.04 Very High Very High Very High
TRP channel 5 93.16 High High
Glutamate 4 92.56 High High
agonist 63 90.44 High High
opiate 18 85.28 High High
Opioid 2 81.20 Quite High
chemokine 1 80.40 Quite High
Disease Link Frequency Relevance Heat
Aging 5 96.32 Very High Very High Very High
Disease 76 94.88 High High
Increased Venous Pressure Under Development 139 85.60 High High
Stress 19 83.52 Quite High
Pressure And Volume Under Development 30 80.64 Quite High
Sleep Disorders 153 80.36 Quite High
Pulmonary Disease 2 71.76 Quite High
INFLAMMATION 16 69.52 Quite High
Pain 4 67.96 Quite High
Altitude Sickness 3 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Negative_regulation (decrease) of Localization (release) of Ca2 in reticulum associated with versed
1) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.16 Pain Relevance 0.27
In Ca2+-free medium pretreatment with 1 microM thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+ pump, abolished 100 microM fluoxetine-induced Ca2+ release.
Negative_regulation (abolished) of Localization (release) of Ca2 in reticulum associated with fluoxetine
2) Confidence 0.38 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11191831 Disease Relevance 0 Pain Relevance 0.60
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Negative_regulation (inhibition) of Localization (release) of Ca2 in reticulum associated with versed
3) Confidence 0.37 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.17 Pain Relevance 0.27
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Negative_regulation (inhibition) of Localization (decrease) of Ca2 in reticulum associated with versed
4) Confidence 0.37 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.17 Pain Relevance 0.27
Furthermore, the PLC pathway may play a role in this release, as suggested by the observation that the Echinacea-evoked increase in cytosolic Ca2+ is blocked by the PLC antagonist U-73122, but not by its inactive analog (U-73343).
Negative_regulation (blocked) of Neg (not) Localization (increase) of Ca2 associated with antagonist
5) Confidence 0.26 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.14 Pain Relevance 0.31
Moreover, although delta-i3L expression also attenuated drastically phospholipase C accumulation and Ca2+ release following mu- and delta-OR stimulation, it failed to inhibit carbachol-mediated stimulation of inositol phosphate accumulation in M1-muscarinic receptor-expressing human embryonic kidney 293 cells.
Negative_regulation (attenuated) of Localization (release) of Ca2 in embryonic kidney
6) Confidence 0.25 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.38
Consistent with our previous findings [20,21], pre-incubation with either Cicaprost or SIN-1 significantly impaired U46619-induced [Ca2+]i mobilization by TP?
Negative_regulation (impaired) of Localization (mobilization) of Ca2
7) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with those previous studies, pre-incubation with SIN-1 specifically impaired U46619-induced [Ca2+]i mobilization in HEK.TP?
Negative_regulation (impaired) of Localization (mobilization) of Ca2
8) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03
On the other hand, pre-stimulation with Cicaprost impaired U46619-induced [Ca2+]i mobilization and RhoA activation by TP?
Negative_regulation (impaired) of Localization (mobilization) of Ca2
9) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
Data presented are representative of at least four independent experiments, and are plotted as changes in intracellular Ca2+ (?
Negative_regulation (plotted) of Localization (changes) of Ca2
10) Confidence 0.23 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
For example, 2-ABP has been shown to potentiate and block Ca2+ entry into cells [180], and it inhibits InsP3 receptor-mediated Ca2+ release [181].
Negative_regulation (inhibits) of Localization (release) of Ca2
11) Confidence 0.22 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.14 Pain Relevance 0.03
The observation that verapamil inhibits ionophore-induced Ca2+ mobilization supports this notion.
Negative_regulation (inhibits) of Localization (mobilization) of Ca2
12) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0 Pain Relevance 0.04
Our results indicate that verapamil may not alter basal Ca2+ content, instead, the Ca2+ wave, possibly due to Ca2+ release from cytosolic compartments, was abolished (Fig. 11).
Negative_regulation (abolished) of Localization (release) of Ca2
13) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.26 Pain Relevance 0.05
Our results indicate that verapamil may not alter basal Ca2+ content, instead, the Ca2+ wave, possibly due to Ca2+ release from cytosolic compartments, was abolished (Fig. 11).
Negative_regulation (abolished) of Localization (release) of Ca2
14) Confidence 0.13 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.26 Pain Relevance 0.05
Why is Ca2+ so critical to the neuron?
Negative_regulation (is) of Localization (critical) of Ca2 in neuron
15) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.58 Pain Relevance 0.14

General Comments

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