INT93565

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 3.75
Pain Relevance 0.91

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molecular_function (NAAA) transcription factor binding (NAAA) biological_process (NAAA)
lipid metabolic process (NAAA) lysosome (NAAA) cytoplasm (NAAA)
Anatomy Link Frequency
PLT 5
blood 1
EPI 1
NAAA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 135 92.08 High High
Inflammatory response 1 92.04 High High
Pain 5 91.92 High High
Inflammatory mediators 25 83.56 Quite High
Angina 2 78.16 Quite High
anesthesia 2 65.92 Quite High
diclofenac 8 50.00 Quite Low
cINOD 52 5.00 Very Low Very Low Very Low
aspirin 25 5.00 Very Low Very Low Very Low
COX-2 inhibitor 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 11 99.80 Very High Very High Very High
Coronary Heart Disease 8 97.64 Very High Very High Very High
Acute Coronary Syndrome 5 96.92 Very High Very High Very High
Hemolysis 2 95.12 Very High Very High Very High
INFLAMMATION 188 92.08 High High
Pain 5 91.92 High High
Fever 10 91.56 High High
Hemorrhage 30 89.84 High High
Myocardial Infarction 7 81.44 Quite High
Disease 310 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLT-reactive antibodies were not detectable.
Neg (not) Gene_expression (detectable) of PLT in PLT
1) Confidence 0.65 Published 2004 Journal Transfusion Section Body Doc Link 15265128 Disease Relevance 0.07 Pain Relevance 0
STUDY DESIGN AND METHODS: All sera samples were evaluated with standard serologic tests for the detection of red blood cells (RBCs) and platelet (PLT) antibodies in the presence of DCF, DCF-urine (DCF-U), and five chemically defined metabolites.
Gene_expression (detection) of PLT in PLT
2) Confidence 0.65 Published 2004 Journal Transfusion Section Body Doc Link 15265128 Disease Relevance 0.10 Pain Relevance 0
The aim of this study was to assess the PLT count, mean PLT volume (MPV), PLT mass, white blood cell (WBC; including eosinophils) and plasma interleukin (IL)-5, in patients with ACS and controls.
Gene_expression (mass) of PLT in PLT associated with acute coronary syndrome
3) Confidence 0.45 Published 2007 Journal Platelets Section Abstract Doc Link 17365849 Disease Relevance 1.06 Pain Relevance 0.20
So, we proposed that fibrinogen and PLT transfusion in combination should be better for infants with high HCT CCHD, but PLT alone might be enough for low HCT ones.
Gene_expression (transfusion) of PLT in PLT associated with coronary heart disease
4) Confidence 0.25 Published 2009 Journal Artif Organs Section Abstract Doc Link 20021469 Disease Relevance 0.10 Pain Relevance 0.05
After therapy, PLT function in both groups restored to T1 level (P > 0.05); Ffg at T4 was significantly better than at T1 (P < 0.01) in group H, but Ffg at T4 with still normal function was lower than at T1 in group L (P < 0.01).
Gene_expression (function) of PLT in PLT
5) Confidence 0.22 Published 2009 Journal Artif Organs Section Abstract Doc Link 20021469 Disease Relevance 0.18 Pain Relevance 0.07
in EC (Camacho et al, 1998), and the production of TXA2 and TXB2 in PLT (Anderson et al, 1978).
Gene_expression (production) of PLT
6) Confidence 0.16 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.23 Pain Relevance 0.03
The diameter of PMN and PLT was set to 10 and 2 ?
Gene_expression (diameter) of PLT
7) Confidence 0.16 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.20 Pain Relevance 0.04
PLT cells produce abundant TXA2, which is a potent inducer of PLT aggregation and vasoconstriction (Smith et al, 1980).
Gene_expression (aggregation) of PLT associated with increased venous pressure under development
8) Confidence 0.16 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.92 Pain Relevance 0.32
The concentration of PMN and PLT in the model is set to the same value as in human blood, that is, 4500 and 2.5 × 105 cells/?
Gene_expression (concentration) of PLT in blood
9) Confidence 0.16 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.25 Pain Relevance 0.03
Ordinary differential equations (ODEs) were constructed to simulate the dynamic course of AA metabolism, where 24, 29 and 11 equations were used for PMN, EC and PLT, respectively (see details in Supplementary information).
Gene_expression (used) of PLT
10) Confidence 0.16 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.53 Pain Relevance 0.18
In patients with severe EPI, the PLT was abnormal in 100% (13/13) and FE1 was abnormal in 85% (11/13) of the cases.
Gene_expression (abnormal) of PLT in EPI
11) Confidence 0.05 Published 2000 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11192324 Disease Relevance 0.11 Pain Relevance 0

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