INT9357

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.88
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
plasma 2
smooth muscle 2
tail 2
thoracic 1
veins 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 4 100.00 Very High Very High Very High
Triptan 5 99.98 Very High Very High Very High
Antinociceptive 1 99.28 Very High Very High Very High
tail-flick 3 98.64 Very High Very High Very High
Sumatriptan 16 98.12 Very High Very High Very High
antagonist 5 94.16 High High
agonist 14 87.60 High High
Potency 2 87.20 High High
Migraine 2 84.32 Quite High
withdrawal 2 56.28 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Nociception 4 94.40 High High
Bordatella Infection 4 88.80 High High
Hyperalgesia 1 75.44 Quite High
Headache 2 61.76 Quite High
Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No differences in magnitude of the effect of the two receptor subtypes were found, indicating that stimulation of either 5-HT1A or 5-HT1B receptors was equipotent in producing the antinociceptive tail-flick response.
Positive_regulation (equipotent) of Positive_regulation (stimulation) of 5-HT1B in tail associated with tail-flick and antinociceptive
1) Confidence 0.49 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1410132 Disease Relevance 0.30 Pain Relevance 0.40
In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release.
Positive_regulation (stimulates) of Positive_regulation (activation) of 5-HT1B in plasma associated with sumatriptan
2) Confidence 0.49 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9040124 Disease Relevance 0 Pain Relevance 0.47
In addition, co-activation of the adenosine A1 receptor (but not the 5-HT1B receptor) potentiates the hydrolysis of inositol phospholipids elicited by receptors coupled to Gq-proteins (Dickenson and Hill, 1996.
Positive_regulation (potentiates) of Positive_regulation (activation) of 5-HT1B associated with adenocard
3) Confidence 0.49 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0 Pain Relevance 0.09
The observation that 5-HT1B receptor activation can potentiate Gq-coupled receptor stimulated second messenger responses may have an important physiological role in the regulation of vascular smooth muscle contraction.
Positive_regulation (potentiate) of Positive_regulation (activation) of 5-HT1B in smooth muscle
4) Confidence 0.49 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0.17 Pain Relevance 0.27
It is concluded that 5-HT-evoked contraction of human coronary arteries is most probably mediated via the activation of both 5-HT1B and 5-HT2A receptors.
Spec (probably) Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT1B
5) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0 Pain Relevance 0.15
In conclusion, triptans induce vasoconstriction in arteries and veins from the thoracic wall, most likely by activation of 5-HT1B receptors.
Spec (likely) Positive_regulation (induce) of in veins Spec (likely) Positive_regulation (activation) of 5-HT1B in thoracic associated with triptan and increased venous pressure under development
6) Confidence 0.49 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821444 Disease Relevance 0.40 Pain Relevance 0.87
5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.
Positive_regulation (increased) of Positive_regulation (contribution) of 5-HT1B
7) Confidence 0.49 Published 2006 Journal Pharmacogenet. Genomics Section Title Doc Link 16847428 Disease Relevance 0 Pain Relevance 0.22

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