INT9358

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 26
Total Number 31
Disease Relevance 11.00
Pain Relevance 17.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
blood vessels 2
plasma 1
smooth muscle 1
tail 1
nucleus 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 6 100.00 Very High Very High Very High
agonist 68 99.88 Very High Very High Very High
Triptan 171 99.86 Very High Very High Very High
Sumatriptan 133 99.84 Very High Very High Very High
trigeminal ganglion 32 99.68 Very High Very High Very High
Migraine 303 99.36 Very High Very High Very High
Pain 140 99.00 Very High Very High Very High
Serotonin 45 98.94 Very High Very High Very High
Central nervous system 15 98.64 Very High Very High Very High
Antinociceptive 2 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Glioma 10 100.00 Very High Very High Very High
Hypertension 2 99.82 Very High Very High Very High
Increased Venous Pressure Under Development 41 99.80 Very High Very High Very High
Ganglion Cysts 35 99.68 Very High Very High Very High
Migraine Disorders 128 99.36 Very High Very High Very High
Pain 140 99.00 Very High Very High Very High
Anxiety Disorder 14 98.88 Very High Very High Very High
Headache 281 98.50 Very High Very High Very High
Cluster Headache 19 97.68 Very High Very High Very High
Cirrhosis 1 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No differences in magnitude of the effect of the two receptor subtypes were found, indicating that stimulation of either 5-HT1A or 5-HT1B receptors was equipotent in producing the antinociceptive tail-flick response.
Positive_regulation (stimulation) of 5-HT1B in tail associated with tail-flick and antinociceptive
1) Confidence 0.67 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1410132 Disease Relevance 0.30 Pain Relevance 0.40
The selective 5HT1B/1D agonist naratriptan has no significant activity at 5HT2 receptors; however, like all 5HT1B/1D agonists developed for the acute treatment of migraine, naratriptan could potentially constrict coronary arteries by activation of 5HT1B receptors.
Positive_regulation (activation) of 5HT1B associated with migraine and agonist
2) Confidence 0.67 Published 2000 Journal Neurology Section Abstract Doc Link 10891912 Disease Relevance 0.17 Pain Relevance 0.40
It is concluded that 5-HT-evoked contraction of human coronary arteries is most probably mediated via the activation of both 5-HT1B and 5-HT2A receptors.
Positive_regulation (activation) of 5-HT1B
3) Confidence 0.67 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0 Pain Relevance 0.15
These findings suggest that 5-HT-induced NO production is mediated by both of 5-HT1B and 5-HT2B receptor activation in HCAECs.
Positive_regulation (activation) of 5-HT1B
4) Confidence 0.67 Published 1998 Journal Kobe J Med Sci Section Abstract Doc Link 10036860 Disease Relevance 0 Pain Relevance 0.33
Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory.
Positive_regulation (Stimulation) of 5-HT1B
5) Confidence 0.67 Published 2007 Journal Behav. Brain Res. Section Title Doc Link 17692935 Disease Relevance 0 Pain Relevance 0.38
Recent advances in basic and applied clinical neuroscience have led to the development of sumatriptan, a new class of selective serotonin (5-hydroxytryptamine (5-HT)) receptor agonists that activate 5-HT 1B/1D receptors.
Positive_regulation (activate) of 5-HT 1B associated with sumatriptan, agonist and serotonin
6) Confidence 0.67 Published 2003 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15152455 Disease Relevance 0.52 Pain Relevance 0.96
Na(+)-dependent metabolic coupling upon 5-HT1B receptor activation by sumatriptan and related agonists.
Positive_regulation (activation) of 5-HT1B associated with sumatriptan and agonist
7) Confidence 0.67 Published 1998 Journal Recept. Channels Section Title Doc Link 9826913 Disease Relevance 0.45 Pain Relevance 0.70
In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release.
Positive_regulation (activation) of 5-HT1B in plasma associated with sumatriptan
8) Confidence 0.67 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9040124 Disease Relevance 0 Pain Relevance 0.47
In addition, co-activation of the adenosine A1 receptor (but not the 5-HT1B receptor) potentiates the hydrolysis of inositol phospholipids elicited by receptors coupled to Gq-proteins (Dickenson and Hill, 1996.
Positive_regulation (activation) of 5-HT1B associated with adenocard
9) Confidence 0.67 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0 Pain Relevance 0.09
The observation that 5-HT1B receptor activation can potentiate Gq-coupled receptor stimulated second messenger responses may have an important physiological role in the regulation of vascular smooth muscle contraction.
Positive_regulation (activation) of 5-HT1B in smooth muscle
10) Confidence 0.67 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0.17 Pain Relevance 0.27
This in turn activates 5-HT1A and 5-HT1B receptors resulting in inhibition of serotonin release into the synaptic cleft.
Positive_regulation (activates) of 5-HT1B in synaptic cleft associated with serotonin
11) Confidence 0.67 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846147 Disease Relevance 0.47 Pain Relevance 0.52
In conclusion, triptans induce vasoconstriction in arteries and veins from the thoracic wall, most likely by activation of 5-HT1B receptors.
Spec (likely) Positive_regulation (activation) of 5-HT1B in thoracic associated with triptan and increased venous pressure under development
12) Confidence 0.49 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821444 Disease Relevance 0.39 Pain Relevance 0.85
By activating 5HT1B/1D-receptors they lead to vasoconstriction of cerebral blood vessels which are dilated during migraine attacks[2].
Positive_regulation (activating) of 5HT1B in blood vessels associated with migraine and increased venous pressure under development
13) Confidence 0.49 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2706221 Disease Relevance 0.70 Pain Relevance 0.71
5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.
Positive_regulation (contribution) of 5-HT1B
14) Confidence 0.49 Published 2006 Journal Pharmacogenet. Genomics Section Title Doc Link 16847428 Disease Relevance 0 Pain Relevance 0.22
Activation of 5-HT1B/1D receptors at the level of the CNS (trigeminal nucleus caudalis) may interrupt central aspects of the headache process.
Positive_regulation (Activation) of 5-HT1B in nucleus associated with headache and central nervous system
15) Confidence 0.49 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.89 Pain Relevance 1.11
Chronic exposure to 5-HT can contribute to pulmonary hypertension through activation of constrictor 5-HT1B receptors and proliferative 5-HT2B receptors, and possibly through direct intracellular effects.
Spec (possibly) Positive_regulation (activation) of 5-HT1B associated with hypertension
16) Confidence 0.49 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16960982 Disease Relevance 0.73 Pain Relevance 0.23
By stimulating 5-HT1B/1D receptors, triptans inhibit the release of CGRP from the perivascular nerve terminals and the trigeminal ganglion cells.
Positive_regulation (stimulating) of 5-HT1B in nerve associated with ganglion cysts, trigeminal ganglion, triptan and calcitonin gene-related peptide
17) Confidence 0.49 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.88 Pain Relevance 1.24
These data suggested that zolmitriptan inhibited IBa by activating 5-HT1B/1D receptors.
Positive_regulation (activating) of 5-HT1B
18) Confidence 0.49 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.07 Pain Relevance 0.23
The results of these studies and the findings of autoradiography and neuroimaging studies, pointed to a possible role of the 5-HT1B/1D receptor in the pathophysiology of OCD.
Spec (possible) Positive_regulation (role) of 5-HT1B associated with anxiety disorder
19) Confidence 0.49 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11041318 Disease Relevance 0.61 Pain Relevance 0.34
In contrast, activation of vascular 5-HT1B receptors would constrict meningeal vessels hence recovering their pre-migraine diameter.
Positive_regulation (activation) of 5-HT1B in vessels associated with migraine
20) Confidence 0.49 Published 1999 Journal Can J Neurol Sci Section Abstract Doc Link 10563226 Disease Relevance 0.90 Pain Relevance 1.08

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