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Context Info
Confidence 0.00
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zic5) nucleus (Zic5) intracellular (Zic5)
DNA binding (Zic5)
Anatomy Link Frequency
hind limb 1
Zic5 (Mus musculus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 1 99.62 Very High Very High Very High
Dorsal horn 2 98.40 Very High Very High Very High
opioid receptor 8 98.32 Very High Very High Very High
Arthritis 1 97.24 Very High Very High Very High
Central nervous system 1 96.94 Very High Very High Very High
agonist 2 93.08 High High
mu opioid receptor 1 89.16 High High
antagonist 1 86.36 High High
Analgesic 1 85.92 High High
Dorsal horn neuron 1 85.76 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 99.46 Very High Very High Very High
Experimental Arthritis 1 97.60 Very High Very High Very High
Nociception 5 82.96 Quite High
Hyperalgesia 1 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using cloned cDNA for OPRs, we demonstrated (1) the distribution of mRNAs for OPRs in the rat central nervous system, (2) coexistence of each type of mRNA for mu-, delta- and kappa-OPRs and pre-protachykinin A mRNA in the dorsal root ganglion neurons, (3) an increased expression of mu- and kappa-OPR mRNAs in the I-II layers of rat lumbar dorsal horn with an adjuvant arthritis in the hind limb, (4) the inhibitions of N- and Q-types of Ca2+ channels by mu- and kappa-OPR agonists and (5) cross-desensitization of the inhibition through a common intracellular phosphorylation-independent mechanism, (6) pharmacological characterization of "antagonist analgesics" as partial agonists at every type of OPRs, and (7) the key-structure(s) of OPRs for discriminative binding of DAMGO to mu-OPR.
Gene_expression (expression) of kappa-OPR in hind limb associated with ganglion cysts, analgesic, dorsal horn, opioid receptor, experimental arthritis, antagonist, root ganglion neuron, agonist, central nervous system and arthritis
1) Confidence 0.00 Published 2000 Journal Yakugaku Zasshi Section Abstract Doc Link 11193380 Disease Relevance 0.57 Pain Relevance 1.25

General Comments

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