INT93607

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 8
Total Number 21
Disease Relevance 5.93
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CHPT1) lipid metabolic process (CHPT1)
Anatomy Link Frequency
amygdala 10
forearm 1
CHPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 1134 99.84 Very High Very High Very High
Pain 590 99.52 Very High Very High Very High
imagery 127 98.20 Very High Very High Very High
abdominal pain 1 91.00 High High
Lasting pain 14 89.64 High High
drug abuse 14 80.08 Quite High
alcohol 37 79.32 Quite High
addiction 14 78.96 Quite High
Pain threshold 6 36.88 Quite Low
intrathecal 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 299 99.52 Very High Very High Very High
Stress 102 97.68 Very High Very High Very High
Congenital Anomalies 2 97.36 Very High Very High Very High
Metastasis 30 96.28 Very High Very High Very High
Hypertension 9 94.08 High High
Stomach Cancer 3 94.04 High High
Colon Cancer 12 92.24 High High
Abdominal Pain 1 91.00 High High
Increased Venous Pressure Under Development 42 90.52 High High
Heart Rate Under Development 140 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active engagement in CPT also decreased subjective pain experience in our subjects (see Supporting Information S1).


CPT Binding (engagement) of associated with pain
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.10 Pain Relevance 0.60
CPT, i.e., to examine amygdala activation during the period of actual engagement in the CPT; 3) anticipation of heat +CPT versus anticipation of heat +CPT/RT, i.e., to examine the degree to which the period of actual engagement versus the entire engagement period affects amygdala activity, and 4) 2-way ANOVA model with repeated measures (3dANOVA2) with anticipation (fixed factor: -CPT, +CPT and +CPT/RT) and subject as a random factor to examine whether amygdala activation is proportional to anticipatory time (AT).


CPT Binding (engagement) of in amygdala associated with amygdala
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.33
As hypothesized, RT period, i.e., active engagement in the CPT, powered the attenuation of amygdala activity during +CPT condition.
CPT Binding (engagement) of in amygdala associated with amygdala
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.09 Pain Relevance 0.58
16), engagement in the CPT during a task with fixed trial duration produced the expected attenuation of amygdala activation, but close analysis suggested that the attenuation occurred during the period of active engagement in CPT, and that amygdala activity increased proportionately during the remainder of each trial, when subjects were passively exposed to the pain cue.
CPT Binding (engagement) of in amygdala associated with pain and amygdala
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2993966 Disease Relevance 0.09 Pain Relevance 0.51
As in Study 1, we first identified for each subject and each trial the (1) RT (reaction time), i.e., the specific time of active engagement in the CPT during the pain anticipation trials.
CPT Binding (engagement) of associated with pain
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.61 Pain Relevance 0.45
16), engagement in the CPT during a task with fixed trial duration produced the expected attenuation of amygdala activation, but close analysis suggested that the attenuation occurred during the period of active engagement in CPT, and that amygdala activity increased proportionately during the remainder of each trial, when subjects were passively exposed to the pain cue.
CPT Binding (engagement) of in amygdala associated with pain and amygdala
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2993966 Disease Relevance 0.09 Pain Relevance 0.51
CPT versus anticipation of heat +CPT, i.e., to directly examine the degree to which engagement in the CPT affected amygdala activity during aversive anticipation; 2) anticipation of heat +CPT/RT versus anticipation of heat ?
CPT Spec (examine) Binding (engagement) of in amygdala associated with amygdala
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.32
These results demonstrated the importance of combining CPT-11 with fluoropyrimidines.
CPT-11 Binding (combining) of
8) Confidence 0.31 Published 2004 Journal BMC Cancer Section Body Doc Link PMC476737 Disease Relevance 0.39 Pain Relevance 0
The binding of camptothecin (CPT) to the DNA-topoisomerase complex is reversible, but it needs to be maintained for maximal inhibitory activity.
CPT Binding (binding) of
9) Confidence 0.31 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11193899 Disease Relevance 0 Pain Relevance 0
This design allowed us to better characterize the effects of active engagement in a CPT on amygdala activity during anticipation of pain and to explicitly examine the role of time in this process.


CPT Spec (examine) Binding (engagement) of in amygdala associated with pain and amygdala
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.29 Pain Relevance 0.51
We performed two separate functional magnetic resonance imaging (fMRI) studies in two sets of healthy human subjects in order to examine activation in the amygdala during cued anticipation of a painful heat stimulus while subjects were engaged in a continuous performance task (CPT) of either a fixed (Study 1) or a parametrically varied (Study 2) duration.
CPT Binding (engaged) of in amygdala associated with pain, amygdala and imagery
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.30 Pain Relevance 0.42
Subjects were engaged in the CPT throughout the entire duration of the paradigm and a single temperature level that was subjectively rated as moderately painful (5 sec; 46–49°C) was delivered to subjects' left volar forearm following a cue.
CPT Binding (engaged) of in forearm associated with pain
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.42
To test the first hypothesis, we performed ROI analysis within bilateral amygdala and compared amygdala activation during anticipation of painful heat while subjects were engaged in the CPT (+CPT) to activation during anticipation of equally painful heat while subjects were not engaged in the CPT (-CPT) (Fig. 1A).
CPT Binding (engaged) of in amygdala associated with pain and amygdala
13) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.07 Pain Relevance 0.72
To test the first hypothesis, we performed ROI analysis within bilateral amygdala and compared amygdala activation during anticipation of painful heat while subjects were engaged in the CPT (+CPT) to activation during anticipation of equally painful heat while subjects were not engaged in the CPT (-CPT) (Fig. 1A).
CPT Binding (engaged) of in amygdala associated with pain and amygdala
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.07 Pain Relevance 0.72
In two separate experiments with two different groups of healthy volunteers, we systematically examined the effects of active engagement in a CPT (a model of “active coping”) on amygdala activity during cued anticipation of pain.
CPT Spec (examined) Binding (engagement) of in amygdala associated with pain and amygdala
15) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.82 Pain Relevance 0.73
This paradigm combined intermittent engagement in a continuous performance task (CPT) with the cued occurrence of thermal stimuli and had two temporal phases (i.e., anticipation and stimulation), two levels of attentional load (i.e., +CPT and -CPT) and two levels of stimulus strength (i.e., painful heat and non-painful warmth).
CPT Binding (engagement) of associated with pain and increased venous pressure under development
16) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.58 Pain Relevance 0.65
In this study, there was no association of CPT and PbB; however, the curve minimum of TWA was at 28 ?
CPT Neg (no) Binding (association) of
17) Confidence 0.30 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314913 Disease Relevance 0.25 Pain Relevance 0
Both SBP and DBP increased just after initiation of the CPT in 9 of 11 subjects.
CPT Binding (initiation) of
18) Confidence 0.24 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 0 Pain Relevance 0
In contrast, interestingly, BP decreased following initiation of CPT in two subjects.
CPT Binding (initiation) of
19) Confidence 0.24 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 1.31 Pain Relevance 0
In contrast, BP decreased for two subjects after initiation of CPT.
CPT Binding (initiation) of
20) Confidence 0.24 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 0 Pain Relevance 0

General Comments

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