INT93614

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ngf, Ntrk1) cell differentiation (Ntrk1) endosome (Ntrk1)
cytoplasm (Ntrk1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
neurons 1
sympathetic 1
Ngf (Rattus norvegicus)
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 18 100.00 Very High Very High Very High
Trk A 9 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
lidocaine 1 83.96 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High
Injury 7 94.20 High High
Hypertrophy 1 91.40 High High
Tooth Injuries 2 83.68 Quite High
Nociception 1 60.20 Quite High
Arrhythmias 2 Under Development 4 38.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus our results suggest that NGF may be mediating repair and pain responses by the sustained upregulation of its cell surface receptor, trk A, in neurons of the trigeminal ganglia.
NGF Positive_regulation (upregulation) of trk A in neurons associated with pain, nerve growth factor and trk a
1) Confidence 0.52 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.75 Pain Relevance 0.67
In summary, this study provides evidence that high-rate electrical stimulation of sympathetic neurons mediates nerve sprouting by an increase in NGF expression that targets the TrkA receptor in an autocrine/paracrine manner.
NGF Positive_regulation (targets) of TrkA receptor in sympathetic associated with nerve growth factor
2) Confidence 0.09 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.09 Pain Relevance 0.38

General Comments

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