INT93620

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 51
Total Number 57
Disease Relevance 59.45
Pain Relevance 12.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
synovium 20
apoptotic cells 14
sciatic nerve 9
T cells 8
Macrophages 4
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1286 99.92 Very High Very High Very High
Demyelination 146 99.60 Very High Very High Very High
Inflammation 1015 99.42 Very High Very High Very High
Sciatic nerve 312 99.24 Very High Very High Very High
cINOD 30 98.68 Very High Very High Very High
aspirin 9 98.20 Very High Very High Very High
Inflammatory response 62 97.40 Very High Very High Very High
Spinal cord 371 96.72 Very High Very High Very High
Inflammatory mediators 19 95.64 Very High Very High Very High
cytokine 466 92.80 High High
Disease Link Frequency Relevance Heat
Apoptosis 2003 100.00 Very High Very High Very High
Arthritis 72 100.00 Very High Very High Very High
Spinal Cord Injury 366 99.98 Very High Very High Very High
Targeted Disruption 325 99.98 Very High Very High Very High
Gastritis 4 99.98 Very High Very High Very High
Rheumatoid Arthritis 1286 99.92 Very High Very High Very High
Lymphatic System Cancer 286 99.84 Very High Very High Very High
Infection 383 99.60 Very High Very High Very High
Demyelinating Disease 191 99.60 Very High Very High Very High
Severe Combined Immunodeficiency 630 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined administration of the intra-articular gene transfer of FasL with other genes and/or certain anti-inflammatory drugs might be an ideal complementary therapeutic approach for the local treatment of RA and other arthropathies.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL in articular associated with inflammation, rheumatoid arthritis, cinod and arthropathy
1) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.16 Pain Relevance 0.43
FasL gene transfer increases the expression of FasL protein and the frequency of apoptotic cells in RA synovium
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis and apoptosis
2) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.94 Pain Relevance 0.24
To investigate the adenovirus vector mediated, time dependent FasL transgene expression in engrafted human synovium in vivo, 1011 virus particles of Ad-FasL per dose were injected into the middle of the implanted human synovium in SCID mice.
Spec (investigate) Positive_regulation (dependent) of Spec (investigate) Gene_expression (expression) of FasL in synovium associated with severe combined immunodeficiency
3) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.58 Pain Relevance 0.03
Time dependent FasL transgene expression in engrafted human synovium in vivo in SCID mice
Positive_regulation (dependent) of Gene_expression (expression) of FasL in synovium associated with severe combined immunodeficiency
4) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.60 Pain Relevance 0.03
Experiments with blocking antibodies or FasL- or Fas-deficient mutant mice demonstrated that in this setting, TCR restimulation causes the expression of FasL, which induces autocrine and/or paracrine killing of Fas-expressing T cells (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Positive_regulation (causes) of Gene_expression (expression) of FasL in T cells
5) Confidence 0.64 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.32 Pain Relevance 0
SCI leads to increased expression of Fas and FasL, which results in the continued activation of microglia and the inflammatory response, inducing a cascade of apoptotic cell death and extension of the initial damage [67].
Positive_regulation (leads) of Gene_expression (expression) of FasL in apoptotic cell associated with inflammatory response, spinal cord injury, apoptosis and death
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.91 Pain Relevance 0.17
These results show that bacterial Sags upregulate the expression of Fas and Fas-L on lymphoma T cells expressing the appropriate TCR V?
Positive_regulation (upregulate) of Gene_expression (expression) of Fas-L in T cells associated with lymphatic system cancer
7) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.91 Pain Relevance 0
In order to study whether Sags were able to induce increases in Fas and Fas-L expression in vivo, CFSE-stained T5 and T8 lymphoma cells were intraperitoneally inoculated and 1 hour later mice received SEE, SEI, SEB or PBS.
Spec (whether) Positive_regulation (induce) of Gene_expression (expression) of Fas-L associated with lymphatic system cancer
8) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.09 Pain Relevance 0
are also crucially involved and closely associated to apoptotic processes, that occur in FasL expression induced by DNA-damaging agents, such as a genotoxic drug and UV radiation [48].
Positive_regulation (induced) of Gene_expression (expression) of FasL associated with apoptosis
9) Confidence 0.55 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.80 Pain Relevance 0.08
are also crucially involved and closely associated to apoptotic processes, that occur in FasL expression induced by DNA-damaging agents, such as a genotoxic drug and UV radiation [48].
Positive_regulation (occur) of Gene_expression (expression) of FasL associated with apoptosis
10) Confidence 0.55 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.79 Pain Relevance 0.08
Consecutive brain sections were evaluated for Fas and FasL expression, in situ DNA fragmentation (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling; TUNEL), morphologic characteristics of apoptotic cell death and leukocyte infiltration.
Positive_regulation (evaluated) of Gene_expression (expression) of FasL in apoptotic cell associated with apoptosis and death
11) Confidence 0.49 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 1.46 Pain Relevance 0.24
Compared with Ad-LacZ gene transfer, Ad-FasL gene transfer induces a significantly increased frequency of apoptotic cells in RA synovium (Figs 3e,f and 4), even though adenovirus vector itself shows a slight effect on enhancing apoptosis in synoviocytes (Fig. 4) and certain other kinds of cells [38,39].
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis and apoptosis
12) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.07 Pain Relevance 0.11
From the point of view that repeated FasL gene transfer can remove RA synovium in vivo (Fig. 5b; Table 1), the FasL gene may function as a sharp scalpel for molecular synovectomy.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis
13) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.08 Pain Relevance 0.23
The survival of macrophages after FasL gene transfer may be necessary for the phagocytosis of apoptotic cells during 'molecular synovectomy' using the 'FasL gene scalpel'.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in apoptotic cells associated with apoptosis
14) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.03 Pain Relevance 0.09
The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene associated with targeted disruption
15) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.75 Pain Relevance 0.13
The survival of macrophages after FasL gene transfer may be necessary for the phagocytosis of apoptotic cells during 'molecular synovectomy' using the 'FasL gene scalpel'.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in apoptotic cells associated with apoptosis
16) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.05 Pain Relevance 0.07
Three days after Ad-FasL gene transfer into RA synovium in vivo, augmented FasL protein expression was observed (Fig. 3c), and an increased frequency of apoptotic cells in RA synovium was detected by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining (Fig. 3f).
Positive_regulation (observed) of Gene_expression (expression) of FasL protein in apoptotic cells associated with rheumatoid arthritis and apoptosis
17) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.22 Pain Relevance 0.34
To investigate the adenovirus vector mediated, time dependent FasL transgene expression in engrafted human synovium in vivo, 1011 virus particles of Ad-FasL per dose were injected into the middle of the implanted human synovium in SCID mice.
Spec (investigate) Positive_regulation (dependent) of Spec (investigate) Gene_expression (expression) of FasL in synovium associated with severe combined immunodeficiency
18) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.58 Pain Relevance 0.03
To identify the clinical potential of FasL gene transfer, RA synovium from six patients was grafted into SCID mice at 200 mg tissue per mouse subcutaneously.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL gene in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
19) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.68 Pain Relevance 0.13
Three days after Ad-FasL gene transfer, the frequency of apoptotic cells increased 15 to 20-fold (Fig. 4).
Positive_regulation (increased) of Gene_expression (transfer) of FasL gene in apoptotic cells associated with apoptosis
20) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.74 Pain Relevance 0.49

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