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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
lung 1
Kras (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 7 98.80 Very High Very High Very High
aspirin 9 96.08 Very High Very High Very High
Inflammation 1 92.88 High High
dorsal root ganglion 1 92.08 High High
nociceptor 6 89.08 High High
Hyperalgesia 4 85.84 High High
COX-2 inhibitor 1 82.40 Quite High
Kinase C 7 75.84 Quite High
Inflammatory mediators 1 67.60 Quite High
IPN 2 62.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 6 99.90 Very High Very High Very High
INFLAMMATION 4 92.88 High High
Ganglion Cysts 1 92.08 High High
Hyperalgesia 4 85.84 High High
Nociception 1 64.60 Quite High
Inflammatory Pain 2 62.40 Quite High
Lung Cancer 2 56.08 Quite High
Cancer 12 50.00 Quite Low
Glioma 6 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that this inhibition of mouse lung tumorigenesis requires induction of apoptosis and inhibition of COX (cyclooxygenase)-1, COX-2, and the incidence of K-ras mutation.
Negative_regulation (inhibition) of K-ras in lung associated with apoptosis
1) Confidence 0.41 Published 2000 Journal Exp. Lung Res. Section Abstract Doc Link 11195467 Disease Relevance 0.49 Pain Relevance 0.61
The speed of control- and caRas-transfected cells was similarly inhibited in the presence of VPA (Figure 5c).
Negative_regulation (inhibited) of caRas
2) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Inhibitors of G(i/o)-proteins, Ras farnesyltransferases, and MEK decreased epinephrine-induced hyper-algesia.
Negative_regulation (Inhibitors) of Ras
3) Confidence 0.01 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.66 Pain Relevance 0.92

General Comments

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