INT93626

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 5
Speculated 4
Reported most in Body
Documents 118
Total Number 122
Disease Relevance 115.24
Pain Relevance 25.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
synovium 15
T cells 9
apoptotic cells 8
brain 5
macrophages 4
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 815 100.00 Very High Very High Very High
rheumatoid arthritis 2805 99.92 Very High Very High Very High
Inflammation 1840 99.60 Very High Very High Very High
Demyelination 155 99.60 Very High Very High Very High
Arthritis 326 99.32 Very High Very High Very High
Sciatic nerve 312 98.76 Very High Very High Very High
cINOD 60 98.68 Very High Very High Very High
Central nervous system 122 98.16 Very High Very High Very High
Infliximab 144 97.96 Very High Very High Very High
withdrawal 12 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 4323 100.00 Very High Very High Very High
Targeted Disruption 511 99.98 Very High Very High Very High
Sprains And Strains 78 99.98 Very High Very High Very High
Rheumatoid Arthritis 2805 99.92 Very High Very High Very High
Lymphatic System Cancer 287 99.84 Very High Very High Very High
Death 986 99.78 Very High Very High Very High
Gastritis 12 99.78 Very High Very High Very High
Toxicity 77 99.72 Very High Very High Very High
Cerebral Toxoplasmosis 22 99.64 Very High Very High Very High
INFLAMMATION 1991 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, reduced expression of the apoptosis regulatory proteins FasL and Bad was found after a single administration of methadone.
Gene_expression (expression) of FasL
1) Confidence 0.75 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.07 Pain Relevance 0
The protection was associated with decreased FasL-expressing cells, cytotoxicity against hepatocytes, and respiratory burst in hepatic leukocytes.
Gene_expression (expressing) of FasL in respiratory
2) Confidence 0.75 Published 2006 Journal Hepatology Section Abstract Doc Link 16729305 Disease Relevance 0.81 Pain Relevance 0.80
To identify the clinical potential of FasL gene transfer, RA synovium from six patients was grafted into SCID mice at 200 mg tissue per mouse subcutaneously.
Gene_expression (transfer) of FasL gene in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
3) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.68 Pain Relevance 0.13
In recent studies, endothelial cells were reported to constitutively express FasL and release soluble FasL [29-31].
Gene_expression (express) of FasL in endothelial cells
4) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.40 Pain Relevance 0.29
The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.
Gene_expression (expression) of FasL associated with targeted disruption
5) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.82 Pain Relevance 0.17
We determined Fas and FasL protein expression in engrafted RA synovium by immunohistochemistry using polyclonal anti-Fas and anti-FasL antibodies.
Spec (determined) Gene_expression (expression) of FasL protein in synovium associated with rheumatoid arthritis
6) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.04 Pain Relevance 0.31
The survival of macrophages after FasL gene transfer may be necessary for the phagocytosis of apoptotic cells during 'molecular synovectomy' using the 'FasL gene scalpel'.
Gene_expression (transfer) of FasL gene in apoptotic cells associated with apoptosis
7) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.03 Pain Relevance 0.09
From the point of view that repeated FasL gene transfer can remove RA synovium in vivo (Fig. 5b; Table 1), the FasL gene may function as a sharp scalpel for molecular synovectomy.
Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis
8) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.08 Pain Relevance 0.23
FasL gene transfer increases the expression of FasL protein and the frequency of apoptotic cells in RA synovium
Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis and apoptosis
9) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.94 Pain Relevance 0.24
FasL gene transfer increases the expression of FasL protein and the frequency of apoptotic cells in RA synovium
Gene_expression (expression) of FasL protein in synovium associated with rheumatoid arthritis and apoptosis
10) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.95 Pain Relevance 0.25
Fas protein is highly expressed in RA synovial lining cells and almost all kinds of inflammatory cells infiltrating the synovium, but FasL protein is poorly expressed in RA synovium [11].
Gene_expression (expressed) of FasL protein in synovium associated with inflammation and rheumatoid arthritis
11) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.05 Pain Relevance 0.31
Time dependent FasL transgene expression in engrafted human synovium in vivo in SCID mice
Gene_expression (expression) of FasL in synovium associated with severe combined immunodeficiency
12) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.60 Pain Relevance 0.03
Compared with Ad-LacZ gene transfer, Ad-FasL gene transfer induces a significantly increased frequency of apoptotic cells in RA synovium (Figs 3e,f and 4), even though adenovirus vector itself shows a slight effect on enhancing apoptosis in synoviocytes (Fig. 4) and certain other kinds of cells [38,39].
Gene_expression (transfer) of FasL gene in synovium associated with rheumatoid arthritis and apoptosis
13) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.07 Pain Relevance 0.11
To investigate the adenovirus vector mediated, time dependent FasL transgene expression in engrafted human synovium in vivo, 1011 virus particles of Ad-FasL per dose were injected into the middle of the implanted human synovium in SCID mice.
Spec (investigate) Gene_expression (expression) of FasL in synovium associated with severe combined immunodeficiency
14) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.58 Pain Relevance 0.03
Three days after Ad-FasL gene transfer into RA synovium in vivo, augmented FasL protein expression was observed (Fig. 3c), and an increased frequency of apoptotic cells in RA synovium was detected by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining (Fig. 3f).
Gene_expression (expression) of FasL protein in apoptotic cells associated with rheumatoid arthritis and apoptosis
15) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.21 Pain Relevance 0.34
The combined administration of the intra-articular gene transfer of FasL with other genes and/or certain anti-inflammatory drugs might be an ideal complementary therapeutic approach for the local treatment of RA and other arthropathies.
Gene_expression (transfer) of FasL in articular associated with inflammation, rheumatoid arthritis, cinod and arthropathy
16) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.16 Pain Relevance 0.43
The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.
Gene_expression (expressed) of FasL mRNA associated with targeted disruption
17) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.67 Pain Relevance 0.08
No transgenic FasL mRNA was detected in Ad-LacZ injected tissues samples (Fig. 2, lanes 7–11).
Neg (No) Gene_expression (detected) of FasL mRNA associated with targeted disruption
18) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.51 Pain Relevance 0
Transgenic FasL mRNA expression in tissue samples was detected by RT-PCR (Fig. 2).
Gene_expression (expression) of FasL mRNA associated with targeted disruption
19) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.46 Pain Relevance 0
The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.
Gene_expression (transfer) of FasL gene associated with targeted disruption
20) Confidence 0.74 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.75 Pain Relevance 0.13

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