INT93647

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.13
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY1) aging (P2RY1) plasma membrane (P2RY1)
signal transducer activity (P2RY1)
Anatomy Link Frequency
platelet 2
blood 1
T cells 1
P2RY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 11 99.38 Very High Very High Very High
aspirin 41 93.08 High High
antagonist 62 92.28 High High
Angina 5 90.16 High High
Serotonin 4 81.44 Quite High
ischemia 1 78.80 Quite High
agonist 24 52.48 Quite High
carpal tunnel syndrome 7 50.00 Quite Low
dopamine receptor 3 47.80 Quite Low
Neuropeptide 2 27.36 Quite Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 13 96.48 Very High Very High Very High
Diabetes Mellitus 14 95.12 Very High Very High Very High
Diabetic Angiopathy 1 94.60 High High
Thrombosis 12 93.76 High High
Disease 15 91.72 High High
Stroke 8 91.52 High High
Myocardial Infarction 39 91.20 High High
Cv General 3 Under Development 10 90.16 High High
Cataract 2 82.08 Quite High
Hemorrhage 13 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study suggests that the residual 2MeS-ADP platelet reactivity after clopidogrel treatment is in part due to an inadequate antagonistic effect of clopidogrel on the P2Y12 receptor and partly due to the P2Y1 receptor, which is unaffected by clopidogrel.
Neg (unaffected) Regulation (unaffected) of P2Y1 in platelet
1) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.11 Pain Relevance 0.03
The distances of the purine P2Y1 receptor, the prostanoid FP receptor, and leukotriene receptor CysLT2 towards the other classes are all larger in substructure space than in sequence space, implicating that overall their ligands show little resemblance with ligands of the other GPCRs.
Regulation (larger) of purine P2Y1 receptor
2) Confidence 0.31 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.04
The remaining 2MeS-ADP activation was dependent on both insufficient P2Y12 blockade by clopidogrel and the unaffected ADP receptor P2Y1.
Neg (unaffected) Regulation (unaffected) of ADP receptor P2Y1
3) Confidence 0.31 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.09 Pain Relevance 0.16
This study also shows the relevance of designing drugs targeting the P2Y1 receptor.


Regulation (targeting) of P2Y1
4) Confidence 0.22 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.05
High glucose-induced release of extracellular nucleotides, acting on P2Y receptors to stimulate VSMC growth via NFAT (nuclear factor of activated T cells) activation, may provide a link between diabetes and diabetic vascular disease [143].
Regulation (acting) of P2Y in T cells associated with diabetic angiopathy and diabetes mellitus
5) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.06 Pain Relevance 0
Identification of the platelet ADP receptor targeted by antithrombotic drugs.
Regulation (targeted) of ADP receptor in platelet associated with cva
6) Confidence 0.01 Published 2001 Journal Nature Section Title Doc Link 11196645 Disease Relevance 0.37 Pain Relevance 0.14
It selectively alters the ADP receptor on the blood platelet resulting in lessened blood aggregation.
Regulation (alters) of ADP receptor in blood
7) Confidence 0.01 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2887503 Disease Relevance 0.51 Pain Relevance 0.14

General Comments

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