INT93658

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Context Info
Confidence 0.72
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 6.85
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
nucleus 2
neuronal 1
bone marrow 1
TMJ 1
cortex 1
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 12 100.00 Very High Very High Very High
ganglionectomy 14 99.76 Very High Very High Very High
Snapping jaw 8 98.76 Very High Very High Very High
Arthritis 18 98.60 Very High Very High Very High
Sciatic nerve 3 98.54 Very High Very High Very High
ischemia 15 97.96 Very High Very High Very High
Clonidine 10 95.96 Very High Very High Very High
withdrawal 5 95.32 Very High Very High Very High
Antinociceptive 7 94.68 High High
phenol injection 4 94.64 High High
Disease Link Frequency Relevance Heat
Nociception 22 99.38 Very High Very High Very High
Injury 7 99.04 Very High Very High Very High
Endotoxemia 7 99.00 Very High Very High Very High
Temporomandibular Joint Syndrome 8 98.76 Very High Very High Very High
Arthritis 18 98.60 Very High Very High Very High
Apoptosis 12 98.58 Very High Very High Very High
Cv Unclassified Under Development 13 97.96 Very High Very High Very High
Cystitis 4 97.92 Very High Very High Very High
Pressure And Volume Under Development 7 95.96 Very High Very High Very High
Infection 29 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nNOS expression and nNOS mRNA were detected by immunohistochemistry and in situ hybridization for nNOS mRNA, respectively.
Transcription (detected) of nNOS
1) Confidence 0.72 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.73
Chronic renal injury caused by phenol was associated with decreased abundance of IL-1beta and nNOS in the PH.
Transcription (abundance) of nNOS associated with injury
2) Confidence 0.69 Published 2002 Journal Am. J. Hypertens. Section Abstract Doc Link 12160195 Disease Relevance 0.95 Pain Relevance 0.38
We examined the effects of nociceptive stimulation on the expression levels of neuronal nitric oxide synthase (nNOS) mRNA, heteronuclear (hn)RNA for AVP and AVP mRNA in the rat paraventricular nucleus (PVN) and supraoptic nucleus (SON), using in situ hybridization histochemistry.
Transcription (levels) of nNOS in nucleus associated with nociception and neuronal nitric oxide synthase
3) Confidence 0.67 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.35 Pain Relevance 0.05
In addition, the expression of AVP heteronuclear (hn) RNA and neuronal nitric oxide synthase (nNOS) mRNA was also examined in the PVN of a CP-induced cystitis model.
Spec (examined) Transcription (expression) of nNOS in neuronal associated with cystitis and neuronal nitric oxide synthase
4) Confidence 0.66 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.26 Pain Relevance 0.05
It has been demonstrated that NADPHd reactivity in the gracile nucleus is markedly increased in intact aged rats and is induced following sciatic nerve axotomy in young rats, accompanied by increased number of cells showing expression of nNOS proteins and mRNA (18,19). nNOS catalyzes the transformation of arginine to NO, which is an endogenous molecule produced in many cell types including neurons in the brain (20,21).
Transcription (expression) of nNOS in gracile nucleus associated with sciatic nerve
5) Confidence 0.64 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.20 Pain Relevance 1.15
However, rosuvastatin had no influence on nNOS mRNA and protein expression.
Transcription (expression) of nNOS
6) Confidence 0.64 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.66 Pain Relevance 0.45
We examined the effects of nociceptive stimulation on the expression levels of neuronal nitric oxide synthase (nNOS) mRNA, heteronuclear (hn)RNA for AVP and AVP mRNA in the rat paraventricular nucleus (PVN) and supraoptic nucleus (SON), using in situ hybridization histochemistry.
Transcription (levels) of neuronal nitric oxide synthase in nucleus associated with nociception and neuronal nitric oxide synthase
7) Confidence 0.59 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.35 Pain Relevance 0.05
CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.
Transcription (transcription) of nNOS
8) Confidence 0.57 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0
To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.
Transcription (levels) of nNOS associated with apoptosis
9) Confidence 0.57 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473255 Disease Relevance 0.56 Pain Relevance 0.13
The nNOS expression and nNOS mRNA were detected by immunohistochemistry and in situ hybridization for nNOS mRNA, respectively.
Transcription (detected) of nNOS
10) Confidence 0.53 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.73
Taking the nNOS molecules to exist in a 7 × 7 array and the extreme case of all of them being simultaneously active, and generating NO at the highest rate achievable from measurements of the activity of purified nNOS after adjusting for temperature (20 s?
Transcription (activity) of nNOS
11) Confidence 0.49 Published 2009 Journal Nitric Oxide Section Body Doc Link PMC2779337 Disease Relevance 0 Pain Relevance 0.19
Discernible down-regulation of nNOS mRNA was not detected until the last phase of endotoxemia.
Neg (not) Transcription (detected) of nNOS associated with endotoxemia
12) Confidence 0.48 Published 2001 Journal Shock Section Abstract Doc Link 11198360 Disease Relevance 0.72 Pain Relevance 0.27
In conclusion, nNOS immunoreactivity and mRNA expression are stable in the Sp5C during TMJ arthritis evolution, but its activity significantly increases in the chronic-phases supporting an antinociceptive role of the nNOS as evidenced by pain threshold experiment.
Transcription (expression) of nNOS in TMJ associated with pain threshold, snapping jaw, antinociceptive and arthritis
13) Confidence 0.45 Published 2009 Journal Brain Res. Section Abstract Doc Link 19769951 Disease Relevance 0.90 Pain Relevance 0.75
The mRNA expression for both nNOS and endothelial nitric oxide synthases (eNOS) presented no noticeable differences among the groups.
Transcription (expression) of nNOS
14) Confidence 0.45 Published 2009 Journal Brain Res. Section Abstract Doc Link 19769951 Disease Relevance 0.88 Pain Relevance 0.62
The mRNA of iNOS as well as eNOS and nNOS can be reliably detected in the mouse bone marrow [15].
Transcription (detected) of nNOS in bone marrow
15) Confidence 0.41 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
Reverse transcriptase-polymerase chain reaction showed augmented levels of mRNAs for both nNOS and iNOS when compared with controls at 8 h after ischemia.
Transcription (levels) of nNOS associated with ischemia
16) Confidence 0.41 Published 2002 Journal Brain Res. Section Abstract Doc Link 12113958 Disease Relevance 0.69 Pain Relevance 0.57
This view is further reinforced by the facts that in our experiments: (i) no significant variation was noticed in nNOS activity/protein and mRNA expression (data not shown); (ii) a specific iNOS inhibitor was capable of reducing the increase in NO production measured in the cortex of mice infected with T. b. brucei (data previously reported from our team [31]).
Transcription (expression) of nNOS in cortex
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.31 Pain Relevance 0.04

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