INT93663

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 72
Total Number 75
Disease Relevance 33.38
Pain Relevance 19.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
chondrocytes 4
fibroblasts 4
plasma 2
keratinocytes 2
macrophage 1
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 971 100.00 Very High Very High Very High
COX2 37 100.00 Very High Very High Very High
cytokine 358 99.82 Very High Very High Very High
Osteoarthritis 658 99.64 Very High Very High Very High
rheumatoid arthritis 510 99.64 Very High Very High Very High
qutenza 21 99.18 Very High Very High Very High
endometriosis 108 98.44 Very High Very High Very High
Arthritis 115 98.20 Very High Very High Very High
tolerance 4 98.08 Very High Very High Very High
Inflammation 561 97.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 41 100.00 Very High Very High Very High
Acute Coronary Syndrome 126 99.96 Very High Very High Very High
Osteoarthritis 630 99.64 Very High Very High Very High
Rheumatoid Arthritis 511 99.64 Very High Very High Very High
Apoptosis 171 99.50 Very High Very High Very High
Arthritis 164 99.24 Very High Very High Very High
Wound Healing 59 99.16 Very High Very High Very High
Endometriosis 138 98.44 Very High Very High Very High
Aging 24 98.04 Very High Very High Very High
Myocardial Infarction 67 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, upregulation of matrix-metallo proteinases (MMPs) and other protease-receptor pairs, like protease-activated receptor 1 (PAR1), facilitate invasion through the basement membrane, providing necessary access to either the lymphatic or vascular circulations [24].
Positive_regulation (upregulation) of MMP in basement membrane
1) Confidence 0.67 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.67 Pain Relevance 0.04
(Beside this, upregulation of MMP-1 takes place physiologically during growth, wound healing, and angiogenesis, and therefore even an upregulation of MMP-1 would not be interpretable automatically as undesired damaging effect.)
Positive_regulation (upregulation) of MMP-1 associated with wound healing
2) Confidence 0.66 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.18 Pain Relevance 0
(Beside this, upregulation of MMP-1 takes place physiologically during growth, wound healing, and angiogenesis, and therefore even an upregulation of MMP-1 would not be interpretable automatically as undesired damaging effect.)
Positive_regulation (upregulation) of MMP-1 associated with wound healing
3) Confidence 0.66 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.17 Pain Relevance 0
The increased protein levels of MMP-1 and MMP-3 were also reduced by 1000 microg/ml HA.
Positive_regulation (increased) of MMP-1 associated with metalloproteinase
4) Confidence 0.61 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.20 Pain Relevance 0.89
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Positive_regulation (Activated) of MMP1 associated with metalloproteinase
5) Confidence 0.56 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.87 Pain Relevance 0.23
Activated MMP1, MMP3, and latent forms of MMP2 and MMP9 bind to and are inhibited by TIMP1 and TIMP2.
Positive_regulation (Activated) of MMP1
6) Confidence 0.56 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.63 Pain Relevance 0.50
Overexpression of TRPV1 greatly increased heat-shock-induced MMP-1 promoter activity in HEK 293 cells.
Positive_regulation (increased) of MMP-1 associated with shock and metalloproteinase
7) Confidence 0.55 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.67 Pain Relevance 0.52
In comparison to the expression data in tissue described above, these results confirm that circulating MMPs and TIMPs do not always reflect the direct tissue situation.
Positive_regulation (circulating) of MMP associated with metalloproteinase
8) Confidence 0.49 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.46 Pain Relevance 0.19
Matrix metalloproteinases (MMPs), angiogenic growth factors, and their receptors are the main targets of an increasing number of clinical trials approved to test the tolerance and therapeutic efficacy of antiangiogenic agents.
Positive_regulation (increasing) of MMP associated with tolerance and metalloproteinase
9) Confidence 0.49 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772931 Disease Relevance 0.60 Pain Relevance 0.10
The activity of MMPs is increased by gene transcription, extracellular activation of the secreted inactive zymogen form, and reduced activity of tissue inhibitors of metalloproteinases.
Positive_regulation (increased) of MMP associated with metalloproteinase
10) Confidence 0.45 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.03 Pain Relevance 0.25
A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells.
Positive_regulation (induced) of MMP associated with qutenza and metalloproteinase
11) Confidence 0.45 Published 2009 Journal J. Cell. Physiol. Section Title Doc Link 19206161 Disease Relevance 0.07 Pain Relevance 0.80
Overexpression and activation of MMPs contributes to many pathologies, including arthritis, cardiovascular disease, tumour progression and lung disease.
Positive_regulation (activation) of MMP in lung associated with pulmonary disease, cancer, cardiovascular disease, metalloproteinase and arthritis
12) Confidence 0.45 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 16101546 Disease Relevance 1.03 Pain Relevance 0.56
Consistent with these findings, upregulation of MMP1, 2, 3 has previously been reported in endometriosis [38-42].
Positive_regulation (upregulation) of MMP1 associated with endometriosis
13) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.07 Pain Relevance 0.37
Even following repeated exposure during up to 10 passages (with single exposure of 340 J/cm² wIRA(+RL), cumulated exposure 3400 J/cm² wIRA(+RL), corresponding to 3000 J/cm² wIRA), there was no systematic induction (less than twofold expression) of the MMP-1 mRNA as assessed with real-time RT-PCR (see Figure 7).
Neg (no) Positive_regulation (induction) of MMP-1 mRNA
14) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.07 Pain Relevance 0
Of note, MMP-1 has been described to be inducible by heat-shock in a temperature-dependent manner in foreskin cells, mediated via an IL-6-dependent autocrine mechanism [50].
Positive_regulation (inducible) of MMP-1 associated with shock
15) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.19 Pain Relevance 0
Both conventional Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and quantitative real-time RT-PCR techniques were used to determine the induction of MMP-1 mRNA at two physiologic temperatures for skin fibroblasts (30°C and 37°C) in single exposure regimens (15-60 minutes wIRA(+RL), 340-1360 J/cm² wIRA(+RL), 300-1200 J/cm² wIRA; 30 minutes UV-A(+BL), 50 J/cm² UV-A(+BL)) and in addition at 30°C in a repeated exposure protocol (up to 10 times 15 minutes wIRA(+RL) with 340 J/cm² wIRA(+RL), 300 J/cm² wIRA at each time).
Positive_regulation (induction) of MMP-1 mRNA in fibroblasts
16) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
induction of MMP-1 and MMP-13 while having either a very modest effect (MMP-9) or no effect (MMP-2, MMP-3, and MMP-14) on other MMP family members (Figure 2).
Positive_regulation (induction) of MMP-1
17) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.06 Pain Relevance 0.12
TRPV1 has been localized in keratinocytes and is suggested to be a mediator of heat-induced matrix metalloproteinase-1 (MMP-1).
Positive_regulation (induced) of MMP-1 in keratinocytes associated with metalloproteinase
18) Confidence 0.39 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19206161 Disease Relevance 0.06 Pain Relevance 0.52
With regard to the multimodal activation of TRPV1, we hypothesize that TRPV1 might also mediate UV-induced MMP-1 in keratinocytes.
Spec (might) Positive_regulation (induced) of MMP-1 in keratinocytes associated with metalloproteinase
19) Confidence 0.39 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19206161 Disease Relevance 0.07 Pain Relevance 0.57
As devices emitting longer wavelengths are widely used in therapeutic and cosmetic interventions and as the induction of MMP-1 by water-filtered infrared-A (wIRA) had been discussed, it was of interest to assess effects of wIRA on the cellular and molecular level known to be possibly involved in cutaneous degeneration.
Positive_regulation (induction) of MMP-1
20) Confidence 0.39 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.18 Pain Relevance 0.05

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