INT93664

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 40
Disease Relevance 36.67
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
chondrocytes 3
cartilage 3
stroma 2
plasma 2
brain 2
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 417 100.00 Very High Very High Very High
Inflammation 108 100.00 Very High Very High Very High
Arthritis 20 99.92 Very High Very High Very High
alcohol 10 99.28 Very High Very High Very High
Osteoarthritis 382 99.16 Very High Very High Very High
cocaine 59 99.08 Very High Very High Very High
rheumatoid arthritis 252 98.84 Very High Very High Very High
fibrosis 15 98.60 Very High Very High Very High
cytokine 46 96.80 Very High Very High Very High
spinal stenosis 154 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 460 100.00 Very High Very High Very High
Prostate Cancer 215 100.00 Very High Very High Very High
INFLAMMATION 123 100.00 Very High Very High Very High
Stress 34 100.00 Very High Very High Very High
Cancer 439 99.96 Very High Very High Very High
Arthritis 27 99.92 Very High Very High Very High
Obesity 729 99.38 Very High Very High Very High
Reprotox - General 1 39 99.24 Very High Very High Very High
Osteoarthritis 382 99.16 Very High Very High Very High
Osteogenic Sarcomas 4 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tumours, TIMP-2 is coexpressed with mutant p53 and BCL-2 [19].
Gene_expression (coexpressed) of TIMP-2 associated with cancer
1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.26 Pain Relevance 0.39
Overexpression of TIMP-1 and TIMP-2 is associated with inhibition of apoptosis and invasive tumour growth [18-20].
Gene_expression (Overexpression) of TIMP-2 associated with cancer and apoptosis
2) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.16 Pain Relevance 0.32
A relation between TIMP-2 expression and topoisomerase II activity has also been suggested [25].
Gene_expression (expression) of TIMP-2
3) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.11 Pain Relevance 0.41
Cells showed a constitutive expression of matrix-metalloproteinase (MMP)-2 as well as tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 mRNAs.
Gene_expression (expression) of TIMP-2 associated with metalloproteinase
4) Confidence 0.65 Published 2002 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11918086 Disease Relevance 0.62 Pain Relevance 0.64
Inhibition of p38MAPK by the specific inhibitor SB203580 resulted in downregulation of MMP-2 mRNA and protein levels as well as gelatinolytic activity, while expression levels of TIMP-1 and TIMP-2 mRNAs were not changed.
Gene_expression (expression) of TIMP-2 associated with metalloproteinase
5) Confidence 0.65 Published 2002 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11918086 Disease Relevance 0.64 Pain Relevance 0.63
1, TIMP-1 and TIMP-2 by ELISA assay
Gene_expression (assay) of TIMP-2
6) Confidence 0.63 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0 Pain Relevance 0.03
1, TIMP-1 and TIMP-2 following the manufacturer's recommendations, using an enzyme-linked immunosorbent assay (ELISA) kit with antibodies that recognized human TGF-?
Gene_expression (following) of TIMP-2
7) Confidence 0.63 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0 Pain Relevance 0
This is the first published report describing the expression of SMOC1 and TIMP2 in BPH tissue.
Gene_expression (expression) of TIMP2 associated with benign prostatic hypertrophy
8) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.82 Pain Relevance 0
Plasma concentrations of MMP1, MMP3, MMP9, TIMP2, and MTC1 did not correlate to tumour stage and grade (Table 2), but also to lymph node involvement or distant metastasis (data not indicated).


Gene_expression (concentrations) of TIMP2 in lymph node associated with cancer and metastasis
9) Confidence 0.57 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.78 Pain Relevance 0.12
Separate analyzes of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, and MTC1 in plasma do not allow a prognostic prediction for tumour grading, staging, or metastasis, but certain combinations could be very helpful.
Spec (analyzes) Gene_expression (analyzes) of TIMP2 in plasma associated with cancer and metastasis
10) Confidence 0.57 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.39 Pain Relevance 0.07
Plasma concentrations of MMPs, TIMPs, and MTC1 except for TIMP2 were higher in the group of metastasized tumours compared to the patients of non-metastasized TCC (Table 1).


Gene_expression (higher) of TIMP2 in Plasma associated with cancer, metalloproteinase and transitional cell carcinoma
11) Confidence 0.57 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.71 Pain Relevance 0.13
Especially, increased expressions of TIMP-1 and TIMP-2 have been implicated in increased fibrosis of a wide variety of human organs, including the liver, kidney, lungs, and heart, by reduced MMPs activities15-19.
Gene_expression (expressions) of TIMP-2 in kidney associated with fibrosis
12) Confidence 0.56 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 1.16 Pain Relevance 0.12
1, TIMP-1 and TIMP-2 produced by fibroblasts might have been attributed to hypertrophy of the ligamentum flavum in patients with lumbar spinal stenosis via autocrine or paracrine fashions.
Gene_expression (produced) of TIMP-2 in spinal associated with hypertrophy and spinal stenosis
13) Confidence 0.56 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 1.16 Pain Relevance 0.22
These are EMP3, FGF2, FGFBP1, IGF1, IGF2, TGFB3, TGFBR2, and TIMP2.
Gene_expression (These) of TIMP2
14) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.72 Pain Relevance 0.03
Taking into consideration that TIMP-2 functions predominantly as an MMP9 inhibitor (through its catalytic domain) and a proMMP2 activator (through its noncatalytic haemopexin domain), the presence of anti-TIMP-2 antibodies may favour accumulation of functional MMP2.
Gene_expression (functions) of TIMP-2
15) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.54 Pain Relevance 0.30
The probes were diluted with assay buffers (MMP1 1:5, MMP2 1:51, MMP3 1:1, MMP9 1:11, TIMP1 1:101, TIMP2 1:4, and MTC1 1:11).
Gene_expression (1:5) of TIMP2
16) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0 Pain Relevance 0.05
In our study celecoxib was able to neutralize the inductive potential of the tumor cell microenvironment by decreasing levels of MMPs, TIMP1, TIMP2, and laminin (Figures 4 and 5).
Gene_expression (levels) of TIMP2 associated with cancer and metalloproteinase
17) Confidence 0.47 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.46 Pain Relevance 0.14
On the other hand, TIMP-1 production was slightly elevated; and TIMP-2 production was markedly inhibited by all of the extracts.
Gene_expression (production) of TIMP-2
18) Confidence 0.42 Published 2000 Journal J Endod Section Abstract Doc Link 11199767 Disease Relevance 0.07 Pain Relevance 0.27
Based on this BMI-dependent leptin dose-response of chondrocytes, we demonstrated that the stimulatory effect of leptin at 100 ng/ml on the expression of IGF-1, collagen type 2 and TIMP-2 was negatively related to the BMI of the patients while a positive association between chondrocyte responsiveness and BMI was found at 500 ng/ml of leptin for IGF-1, collagen type 2 and MMP-13 (Figure 3).


Gene_expression (expression) of TIMP-2 in chondrocyte associated with obesity
19) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.12 Pain Relevance 0.11
One of the most relevant findings arising from this study is the BMI-dependent effect of leptin on the expression of the genes encoding TIMP-2 and MMP-13 in chondrocytes.
Gene_expression (expression) of TIMP-2 in chondrocytes associated with obesity
20) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.53 Pain Relevance 0.18

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