INT93665

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 41 100.00 Very High Very High Very High
rheumatoid arthritis 63 99.52 Very High Very High Very High
cytokine 2 97.48 Very High Very High Very High
Inflammation 11 97.12 Very High Very High Very High
Arthritis 5 89.20 High High
pulpitis 2 78.16 Quite High
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 115 99.84 Very High Very High Very High
Rheumatoid Arthritis 63 99.52 Very High Very High Very High
Cancer 53 99.48 Very High Very High Very High
INFLAMMATION 10 97.12 Very High Very High Very High
Prostate Cancer 45 92.80 High High
Experimental Arthritis 1 90.24 High High
Melanoma 5 85.08 High High
Apoptosis 14 79.92 Quite High
Pulpitis 2 71.84 Quite High
Arthritis 5 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A relation between TIMP-2 expression and topoisomerase II activity has also been suggested [25].
Negative_regulation (relation) of Gene_expression (expression) of TIMP-2
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.12 Pain Relevance 0.42
This is the first published report describing the expression of SMOC1 and TIMP2 in BPH tissue.
Negative_regulation (describing) of Gene_expression (expression) of TIMP2 associated with benign prostatic hypertrophy
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.82 Pain Relevance 0
On the other hand, TIMP-1 production was slightly elevated; and TIMP-2 production was markedly inhibited by all of the extracts.
Negative_regulation (inhibited) of Gene_expression (production) of TIMP-2
3) Confidence 0.31 Published 2000 Journal J Endod Section Abstract Doc Link 11199767 Disease Relevance 0.07 Pain Relevance 0.27
In our study celecoxib was able to neutralize the inductive potential of the tumor cell microenvironment by decreasing levels of MMPs, TIMP1, TIMP2, and laminin (Figures 4 and 5).
Negative_regulation (decreasing) of Gene_expression (levels) of TIMP2 associated with cancer and metalloproteinase
4) Confidence 0.26 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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