INT93673

Context Info Confidence 0.66 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 19 Total Number 21 Disease Relevance 9.27 Pain Relevance 8.26

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)

Anatomy Link Frequency neurons 2 neuronal 1 spinal nerve 1 brain 1 cerebellum 1 Creb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 188 99.76 Spinal nerve ligature 2 99.50 Calcitonin gene-related peptide 23 99.48 Morphine 14 99.36 antidepressant 28 99.10 COX2 2 98.92 long-term potentiation 56 98.44 antagonist 20 98.28 Opioid 12 97.80 Desipramine 1 97.32

Disease Link Frequency Relevance Heat Diabetes Mellitus 270 99.00 Aids-related Complex 84 98.80 Schizophrenia 443 98.44 Apoptosis 62 98.12 Stress 76 97.40 Drug Dependence 7 95.52 Congenital Anomalies 94 95.38 Anxiety Disorder 10 94.04 Nociception 45 92.88 Pain 51 92.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CGRP increased phosphorylated CREB immunoreactivity and CRE-dependent transcription in neurons, indicating the involvement of the transcription factor CREB.

Transcription (transcription) of CREB in neurons associated with calcitonin gene-related peptide

1) Confidence 0.66 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12629185 Disease Relevance 0.13 Pain Relevance 0.79

We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.

Transcription (transcription) of CREB associated with dopamine and diabetes mellitus

2) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.80 Pain Relevance 0.44

This study demonstrated for the first time that STZ-induced diabetes produces a marked attenuation of cerebral cortical and cerebellum function mediated through dopaminergic receptors, phospholipase C activity and transcription factor CREB in the Wistar rats.

Transcription (transcription) of CREB in cerebellum associated with diabetes mellitus

3) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 1.55 Pain Relevance 0.13

The dopamine D1 signal transduction pathway, activation of the transcription factor CREB, and dopamine-mediated gene expression are critically involved in memory processing, behavioural responses and drug addiction [63].

Transcription (transcription) of CREB associated with drug dependence, addiction and dopamine

4) Confidence 0.64 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.51 Pain Relevance 0.43

Phospho-CREB-induced gene transcription and strengthened synaptic transmission were widely reported in neuronal processing of various extracellular signals [8,13,14,17,20-22].

Transcription (transcription) of Phospho-CREB in neuronal

5) Confidence 0.59 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0 Pain Relevance 0.14

Here, we provide direct evidence that a brief increase in CREB-dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors.

Transcription (transcription) of CREB-dependent in neurons associated with pain and anxiety disorder

6) Confidence 0.59 Published 2009 Journal Hippocampus Section Abstract Doc Link 19004015 Disease Relevance 0.28 Pain Relevance 0.14

Synaptic activity-dependent phosphorylation of the transcription factor cAMP response element binding protein (CREB) leads to CREB-dependent gene transcription, a process thought to underlie long-term hippocampal synaptic plasticity and memory formation.

Transcription (transcription) of CREB-dependent

7) Confidence 0.59 Published 2009 Journal Hippocampus Section Abstract Doc Link 19004015 Disease Relevance 0 Pain Relevance 0.04

Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity.

Transcription (activity) of CREB associated with calcitonin gene-related peptide

8) Confidence 0.51 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.05 Pain Relevance 1.35

Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE-dependent gene COX-2 (cyclooxygenase 2), which also depends strictly on Ca(V)1.2 activation.

Transcription (transcription) of CREB in spinal nerve associated with spinal nerve ligature and cox2

9) Confidence 0.49 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089916 Disease Relevance 0.68 Pain Relevance 1.05

Subsequently, CREB phosphorylated at serine133 (p-CREB) further induces transcription of genes containing cAMP response element (CRE) binding sites in their promoter regions [31], such as c-fos, NK-1, BDNF, and trkB [32-34].

Transcription (transcription) of cAMP response element

10) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.38 Pain Relevance 0.44

such as the MAPK/ERK [41], the transcription factor CREB [42, 43] as well as the IEGs Arc [7], Zif268 [9, 44], and Egr3 [45] have been shown to be crucial for

Transcription (transcription) of CREB associated with aids-related complex

11) Confidence 0.33 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.47 Pain Relevance 0.14

The discussion of abnormalities in synaptogenesis discussed above described the possible role of MAPK in BPA impairment of estrogen-induced hippocampal synaptogenesis.109 Schizophrenia and BPA exposure may be further related through MAPK by BPA's effects on the transcription factor cAMP-responsive element-binding protein (CREB).

Transcription (transcription) of cAMP-responsive element-binding protein associated with congenital anomalies and schizophrenia

12) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.74 Pain Relevance 0.15

The discussion of abnormalities in synaptogenesis discussed above described the possible role of MAPK in BPA impairment of estrogen-induced hippocampal synaptogenesis.109 Schizophrenia and BPA exposure may be further related through MAPK by BPA's effects on the transcription factor cAMP-responsive element-binding protein (CREB).

Transcription (transcription) of CREB associated with congenital anomalies and schizophrenia

13) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.74 Pain Relevance 0.15

Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy.

Transcription (transcription) of cAMP-responsive element binding factor associated with morphine

14) Confidence 0.23 Published 2008 Journal FEBS J. Section Title Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.87

We found brain region-specific alterations in mRNA and protein levels of CAM-L1, laminin, and pCREB in rats chronically treated with the noradrenergic antidepressant desipramine and, to a lesser extent, in those treated with fluoxetine.

Transcription (levels) of pCREB in brain associated with desipramine, antidepressant and fluoxetine

15) Confidence 0.21 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.56 Pain Relevance 0.35

Cellular studies also highlight the relevance of other ATF/CREB family members which can affect Ca2+/cAMP response element (CRE) controlled transcription as well as other transcription factors which make the opioid induction longer lasting.

Transcription (transcription) of CREB associated with opioid

16) Confidence 0.19 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200184 Disease Relevance 0.07 Pain Relevance 0.82

These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I?

Transcription (transcription) of CREB

17) Confidence 0.15 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.54 Pain Relevance 0.03

These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I?

Transcription (transcription) of cAMP-response element binding protein

18) Confidence 0.15 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.53 Pain Relevance 0.03

BDNF has been reported to activate transcription factors, such as CREB and NF?

Transcription (transcription) of CREB

19) Confidence 0.15 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.03

Chronic antidepressant treatment leads to enhanced TrkB signaling, CREB activation [20, 59–61], and transcription of genes associated with BDNF-induced LTP.

Transcription (transcription) of CREB associated with antidepressant and long-term potentiation

20) Confidence 0.10 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.52

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