INT93673
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
CGRP increased phosphorylated CREB immunoreactivity and CRE-dependent transcription in neurons, indicating the involvement of the transcription factor CREB. | |||||||||||||||
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We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control. | |||||||||||||||
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This study demonstrated for the first time that STZ-induced diabetes produces a marked attenuation of cerebral cortical and cerebellum function mediated through dopaminergic receptors, phospholipase C activity and transcription factor CREB in the Wistar rats. | |||||||||||||||
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The dopamine D1 signal transduction pathway, activation of the transcription factor CREB, and dopamine-mediated gene expression are critically involved in memory processing, behavioural responses and drug addiction [63]. | |||||||||||||||
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Phospho-CREB-induced gene transcription and strengthened synaptic transmission were widely reported in neuronal processing of various extracellular signals [8,13,14,17,20-22]. | |||||||||||||||
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Here, we provide direct evidence that a brief increase in CREB-dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors. | |||||||||||||||
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Synaptic activity-dependent phosphorylation of the transcription factor cAMP response element binding protein (CREB) leads to CREB-dependent gene transcription, a process thought to underlie long-term hippocampal synaptic plasticity and memory formation. | |||||||||||||||
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Acid elevated the transcriptional activity of CREB, which in turn stimulated CGRP gene promoter activity. | |||||||||||||||
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Moreover, spinal nerve ligation animals showed enhanced transcription of the CREB/CRE-dependent gene COX-2 (cyclooxygenase 2), which also depends strictly on Ca(V)1.2 activation. | |||||||||||||||
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Subsequently, CREB phosphorylated at serine133 (p-CREB) further induces transcription of genes containing cAMP response element (CRE) binding sites in their promoter regions [31], such as c-fos, NK-1, BDNF, and trkB [32-34]. | |||||||||||||||
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such as the MAPK/ERK [41], the transcription factor CREB [42, 43] as well as the IEGs Arc [7], Zif268 [9, 44], and Egr3 [45] have been shown to be crucial for | |||||||||||||||
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The discussion of abnormalities in synaptogenesis discussed above described the possible role of MAPK in BPA impairment of estrogen-induced hippocampal synaptogenesis.109 Schizophrenia and BPA exposure may be further related through MAPK by BPA's effects on the transcription factor cAMP-responsive element-binding protein (CREB). | |||||||||||||||
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The discussion of abnormalities in synaptogenesis discussed above described the possible role of MAPK in BPA impairment of estrogen-induced hippocampal synaptogenesis.109 Schizophrenia and BPA exposure may be further related through MAPK by BPA's effects on the transcription factor cAMP-responsive element-binding protein (CREB). | |||||||||||||||
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Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy. | |||||||||||||||
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We found brain region-specific alterations in mRNA and protein levels of CAM-L1, laminin, and pCREB in rats chronically treated with the noradrenergic antidepressant desipramine and, to a lesser extent, in those treated with fluoxetine. | |||||||||||||||
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Cellular studies also highlight the relevance of other ATF/CREB family members which can affect Ca2+/cAMP response element (CRE) controlled transcription as well as other transcription factors which make the opioid induction longer lasting. | |||||||||||||||
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These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I? | |||||||||||||||
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These include Gsk3, BAD, p21Cip1/WAF1, p27Kip1, and certain transcription factors and transcription factor regulators such as cAMP-response element binding protein (CREB), the FOXO family of Forkhead transcription factors, I? | |||||||||||||||
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BDNF has been reported to activate transcription factors, such as CREB and NF? | |||||||||||||||
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Chronic antidepressant treatment leads to enhanced TrkB signaling, CREB activation [20, 5961], and transcription of genes associated with BDNF-induced LTP. | |||||||||||||||
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