INT93677

Context Info Confidence 0.70 First Reported 2000 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 5 Disease Relevance 2.89 Pain Relevance 0.90

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency lymph node 2 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 6 97.80 Morphine 2 97.12 opiate 1 90.76 cocaine 1 79.08 anesthesia 1 78.96 addiction 2 73.76 palliative 6 5.00 methotrexate 3 5.00

Disease Link Frequency Relevance Heat Breast Cancer 106 98.16 Metastasis 44 98.16 Disease 21 91.96 Cancer 86 84.96 Peptic Ulcer 2 83.92 Malignant Neoplastic Disease 3 73.64 Drug Dependence 1 67.04 Body Weight 1 65.60 Recurrence 30 65.52 Aggression 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, low uPA mRNA expression was not significantly associated with longer metastasis-free survival (p = 0.41) (Figure 4).

Transcription (expression) of uPA associated with metastasis

1) Confidence 0.70 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.37 Pain Relevance 0

Cellular studies also highlight the relevance of other ATF/CREB family members which can affect Ca2+/cAMP response element (CRE) controlled transcription as well as other transcription factors which make the opioid induction longer lasting.

Transcription (transcription) of ATF associated with opioid

2) Confidence 0.67 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200184 Disease Relevance 0.07 Pain Relevance 0.82

Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer Background

Transcription (expression) of urokinase plasminogen activator in lymph node associated with breast cancer

3) Confidence 0.52 Published 2006 Journal BMC Cancer Section Title Doc Link PMC1564186 Disease Relevance 0.58 Pain Relevance 0

Irsogladine failed to inhibit proliferation, tubular formation, and the uPA/MMP-1 mRNA expression of HUVEC cells.

Transcription (expression) of uPA

4) Confidence 0.52 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14758089 Disease Relevance 1.01 Pain Relevance 0.08

To our knowledge, we are the first to evaluate the prognostic impact of uPA and PAI-1 at the mRNA level in a specific group of lymph node positive- and hormone receptor-positive breast cancers.

Transcription (level) of uPA in lymph node associated with breast cancer

5) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.88 Pain Relevance 0

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