INT93684

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 66
Total Number 72
Disease Relevance 34.42
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
HSG 4
myocardium 3
nucleus 3
circulatory system 2
Th17 cells 2
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 513 100.00 Very High Very High Very High
anesthesia 70 99.82 Very High Very High Very High
cINOD 24 98.68 Very High Very High Very High
imagery 116 97.44 Very High Very High Very High
Inflammation 471 95.88 Very High Very High Very High
Crohn's disease 343 95.48 Very High Very High Very High
Inflammatory mediators 30 95.08 Very High Very High Very High
Inflammatory response 58 91.32 High High
spinal inflammation 41 90.04 High High
dexamethasone 67 83.16 Quite High
Disease Link Frequency Relevance Heat
Glioma 646 99.98 Very High Very High Very High
Cancer 1441 99.90 Very High Very High Very High
Disease 659 99.80 Very High Very High Very High
INFLAMMATION 561 99.60 Very High Very High Very High
Cirrhosis 173 99.54 Very High Very High Very High
Injury 125 99.40 Very High Very High Very High
Hepatitis 99 99.36 Very High Very High Very High
Chronic Hepatitis 93 99.34 Very High Very High Very High
Fibromyalgia 2 99.12 Very High Very High Very High
Glioblastoma 363 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sulfone metabolite of sulindac, which lacks cyclooxygenase-inhibitory activity, did not affect either Stat3 expression or Stat3 phosphorylation.
Gene_expression (expression) of Stat3
1) Confidence 0.78 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.72 Pain Relevance 0.14
Treatment of HSY and HSG cells with the NSAID sulindac, but not other COX inhibitors, induced significant decreases in cell proliferation and increases in apoptosis, accompanied by down-regulation of Stat3 and survivin expression.
Gene_expression (expression) of Stat3 in HSG
2) Confidence 0.78 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19272804 Disease Relevance 0.12 Pain Relevance 0
RESULTS: Messenger RNA and protein expression of Stat3 and survivin was detected in HSY and HSG cell lines.
Gene_expression (expression) of Stat3 in HSG
3) Confidence 0.78 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19272804 Disease Relevance 0.16 Pain Relevance 0
In addition, the effects of the NSAID sulindac and other cyclooxygenase (COX) inhibitors on Stat3 and survivin expression and on cell proliferation and apoptosis of HSY and HSG cells were analyzed.
Gene_expression (expression) of Stat3 in HSG
4) Confidence 0.78 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19272804 Disease Relevance 0.17 Pain Relevance 0
Targeting of Stat3 constitutive expression by the nonsteroidal antiinflammatory drug (NSAID) sulindac has been demonstrated to exert antineoplastic effects in oral squamous cell carcinoma cells in vitro and in vivo.
Gene_expression (expression) of Stat3 associated with inflammation, cinod and skin cancer
5) Confidence 0.78 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 19272804 Disease Relevance 0.55 Pain Relevance 0.17
Perhaps it is the tumor expression of IL-23, IL-6, epidermal growth factor or Janus kinase 2 or an undefined factor that ultimately regulates the expression of PBMC p-STAT-3 levels, but this was not determined in our current study.
Gene_expression (expression) of PBMC p-STAT-3 associated with cancer
6) Confidence 0.76 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.54 Pain Relevance 0.08
The levels of PTH (0 pg/ml), PTH-related peptide, vitamin D, vitamin A, IGF-1, STH, 5-HIES and interleukin 6 were within normal limits.
Gene_expression (levels) of HIES
7) Confidence 0.75 Published 2001 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 11200666 Disease Relevance 0.09 Pain Relevance 0
Immunohistochemical analysis of muscle cross-sections was performed for the quantification of SCs (Pax7+ cells) as well as the expression of phosphorylated STAT3, IL-6, IL-6R?
Gene_expression (expression) of STAT3 in muscle
8) Confidence 0.73 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0.04
Although STATs are known to play critical roles as transcription factors for regulating cell proliferation and survival,6 recent studies have identified other roles, including association at FAC and cell-cell junctions that may contribute to cell motility via alteration in adhesions and/or the cytoskeleton.7-10 Of the six different STATs reported in humans, STAT3 is found to be widely expressed and also known to prevent apoptosis in different cell types.11 STAT3 has become a recent focus of interest in cardiac research since its activation has been demonstrated during hypertrophy.12, 13 Indeed, cardiac-restricted STAT3 knockout in mice14, 15 implicated its importance to cardiac physiology as deletion leads to several detrimental effects, including increased sensitivity to injury, decreased LV capillary formation, increased fibrosis, and decreased contractile function.
Gene_expression (expressed) of STAT3 in capillary associated with targeted disruption, fibrosis, hypertrophy, injury, apoptosis and adhesions
9) Confidence 0.71 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.73 Pain Relevance 0.04
Presence of STAT3 at FAC sites has been demonstrated previously7 to enhance FAK activity.39 Furthermore, evidence exists for STAT3 interaction with other components of the cytoskeleton, including paxillin, p130Cas, and stathmin.10 Therefore, STAT3 presence in the MSK of 48 h PO myocardium is indicative of its possible role at the FAC for cytoskeletal remodeling, independent of its transcriptional role.
Gene_expression (presence) of STAT3 in myocardium
10) Confidence 0.71 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Further analysis in vivo in 48 h PO myocardium showed the presence of both STAT3 and BMX in the detergent-insoluble fraction with their complex formation and phosphorylation.
Gene_expression (presence) of STAT3 in myocardium
11) Confidence 0.71 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.36 Pain Relevance 0
In sham control cat ventricles, STAT3 was predominantly cytoplasmic and P-STAT3 was barely detectable.
Gene_expression (detectable) of STAT3 in ventricles
12) Confidence 0.71 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
However, we do find many of the MSK proteins in the CSK fraction obtained during low-speed centrifugation.3 In the present in vitro studies, analysis of the detergent soluble and insoluble-pellet (CSK+MSK) fractions revealed that STAT3 was predominantly present in the detergent soluble fraction under normal conditions (Figure 1c, top panel), similar to what was observed in in vivo control tissue.
Gene_expression (present) of STAT3
13) Confidence 0.71 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Moreover, the cell-type and line specific differences in STAT3 and ERK signaling were not due different expression of the signaling proteins as demonstrated by the comparable expression level of total STAT3 and ERK proteins among the cell types (Fig. 1C).


Gene_expression (expression) of STAT3
14) Confidence 0.70 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.24 Pain Relevance 0.15
However, many factors have been identified that induce p-STAT-3 expression, including growth factors and cytokines, such as IL-6 [44], elaborated by reactive astrocytes [45], epidermal growth factor [43], and Janus kinase 2 [46], and it is uncertain which of these, either individually or in combination, is the etiological agent for inducing p-STAT-3 in PBMC.
Gene_expression (expression) of STAT-3 in astrocytes associated with cytokine
15) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.54 Pain Relevance 0.08
Higher percentage of PBMCs expresses p-STAT-3 in glioma patients than in healthy donors
Gene_expression (expresses) of STAT-3 associated with glioma
16) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 1.16 Pain Relevance 0
To ascertain if PBMC expression of p-STAT-3 correlated with the degree of immune suppression, we directed our attention specifically to the Treg fraction in the CD4 compartment since the Treg fraction is elevated in patients with malignant glioma patients [35].
Gene_expression (expression) of STAT-3 associated with glioma
17) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.48 Pain Relevance 0.08
However, we did not find a statistically significant correlation between PBMC expression of p-STAT-3 and an increase in the Treg fraction; this is similar to our previous finding of a lack of correlation between glioma-expressed p-STAT-3 and the presence of intratumoral Tregs [3].
Gene_expression (expression) of STAT-3 associated with glioma
18) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.48 Pain Relevance 0.07
Anderson, insufficient sample numbers were obtained from patients with low-grade gliomas (denoted by stars), precluding a sufficiently powered conclusion; however, the low-grade glioma samples that were analyzed and also drawn during general anesthesia did not express p-STAT-3 levels above levels expressed in samples from healthy donors.
Neg (not) Gene_expression (express) of STAT-3 associated with anesthesia and glioma
19) Confidence 0.66 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.81 Pain Relevance 0.21
Association with disease was also detected for 2 variants within STAT3 (rs6503695, P?
Gene_expression (detected) of STAT3 associated with disease
20) Confidence 0.66 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 1.33 Pain Relevance 0.60

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