INT937

Context Info Confidence 0.70 First Reported 1972 Last Reported 2010 Negated 8 Speculated 2 Reported most in Abstract Documents 195 Total Number 197 Disease Relevance 37.82 Pain Relevance 49.30

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)

Anatomy Link Frequency uterine 20 plasma 18 myometrium 6 neurons 4 cervix 4 Oxt (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 179 100.00 epidural 149 100.00 anesthesia 38 100.00 Enkephalin 14 100.00 Dynorphin 3 100.00 Morphine 64 99.98 narcan 48 99.98 analgesia 156 99.90 fluoxetine 15 99.84 Antinociceptive 6 99.78

Disease Link Frequency Relevance Heat Appetite Loss 16 99.90 Reprotox - General 1 62 99.86 Hypertension 22 99.86 Dysmenorrhea 154 99.76 Pain 160 99.70 Asthma 136 99.70 Embryonal Carcinoma 161 99.68 Targeted Disruption 31 99.60 Cicatrix 2 99.60 Asphyxia 158 99.58

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth.

Positive_regulation (increased) of oxytocin in plasma

1) Confidence 0.70 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.15 Pain Relevance 0.11

During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases.

Positive_regulation (increases) of oxytocin

2) Confidence 0.69 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.06 Pain Relevance 0.49

This opioid restraint is the predominant damper of oxytocin cells before and during parturition, limiting stimulation by extraneous stimuli, and perhaps facilitating optimal spacing of births and economical use of the store of oxytocin accumulated during pregnancy.

Positive_regulation (accumulated) of oxytocin associated with opioid

3) Confidence 0.69 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.06 Pain Relevance 0.51

When our results were compared to those of others who used oxytocin liberally we found that oxytocin augmentation was not a major factor in increasing significantly the success and vaginal delivery rate.

Positive_regulation (augmentation) of oxytocin

4) Confidence 0.68 Published 1987 Journal Am J Perinatol Section Abstract Doc Link 3566882 Disease Relevance 0.08 Pain Relevance 0.25

During a trial of labor, oxytocin induction or augmentation is effective in a majority of patients.

Positive_regulation (induction) of oxytocin

5) Confidence 0.68 Published 1987 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3799769 Disease Relevance 0.06 Pain Relevance 0.07

We hypothesize that this forward shift in the initiation of the estradiol surge induces nocturnal uterine contractions by oxytocin release and/or increase in uterine oxytocin receptors and generates molecular messages that are the genesis for labor and delivery in the baboon.

Positive_regulation (increase) of oxytocin in uterine associated with dismenorea

6) Confidence 0.68 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1957886 Disease Relevance 0.28 Pain Relevance 0.33

The high rates of oxytocin augmentation in these primiparous labours may account for the failure of delayed pushing to increase the spontaneous delivery rate in our population.

Positive_regulation (augmentation) of oxytocin

7) Confidence 0.68 Published 1991 Journal Br J Clin Pract Section Abstract Doc Link 1793712 Disease Relevance 0 Pain Relevance 0.23

A temporary increase in the uterotonic effects of endogenous or exogenous oxytocin may then produce a tetanic uterine contraction with subsequent decrease fetal oxygen delivery and resultant fetal bradycardia.

Positive_regulation (increase) of oxytocin in uterine associated with cv unclassified under development

8) Confidence 0.68 Published 1996 Journal Drug Saf Section Abstract Doc Link 8713692 Disease Relevance 0.33 Pain Relevance 1.35

Women at term with prelabour rupture of the membranes should therefore be reassured that immediate induction with oxytocin currently appears to be the best policy with respect to maternal and neonatal morbidity.

Positive_regulation (induction) of oxytocin associated with rupture

9) Confidence 0.68 Published 1999 Journal Aust N Z J Obstet Gynaecol Section Abstract Doc Link 10554936 Disease Relevance 0.64 Pain Relevance 0.06

Although epidural anesthesia was observed to be a very safe procedure, three of the variables (higher use of low forceps, increased use of oxytocin, and greater total costs) may be of some clinical importance and should be considered by both the delivering physician and the patients when choosing obstetrical anesthesia.

Positive_regulation (increased) of oxytocin in forceps associated with anesthesia and epidural

10) Confidence 0.68 Published 1982 Journal J Fam Pract Section Abstract Doc Link 7077246 Disease Relevance 0 Pain Relevance 1.21

OBJECTIVE: To determine the gradient of pressure between the upper and the lower uterine segments of parturients with non-progressing labor and to see whether the gradient correlates with subsequent successful oxytocin augmentation.

Spec (whether) Positive_regulation (augmentation) of oxytocin in uterine

11) Confidence 0.68 Published 1993 Journal Obstet Gynecol Section Abstract Doc Link 8459952 Disease Relevance 0.07 Pain Relevance 0.07

When oxytocin was used electively there was a reduction in the length of the first stage of labour from 696 min to 578 min, (P < 0.05) even though more than half of the control group (53%) required oxytocin augmentation.

Positive_regulation (augmentation) of oxytocin

12) Confidence 0.68 Published 1995 Journal Int J Obstet Anesth Section Abstract Doc Link 15636982 Disease Relevance 0.07 Pain Relevance 0.28

The studied variables were age, weight, height, sensory and motor block, mean blood pressure and maternal-fetal heart rates, number of bolus doses, total local anesthetic administered, duration and type of delivery, oxytocin increase, Apgar at 1 and 5 minutes, plasma levels of local anesthetic (30 minutes after the initial dose, at the end of dilation, in the umbilical vein, and 30 minutes after switching off the perfusion pump), time to clearance, elimination half-life, and a test of histamine release by radioimmunoassay.

Positive_regulation (increase) of oxytocin in umbilical vein

13) Confidence 0.68 Published 2004 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 15200183 Disease Relevance 0 Pain Relevance 0

Increasing the oxytocin infusion earlier, could cause excessive uterine contractions and fetal distress.

Positive_regulation (Increasing) of oxytocin in uterine associated with dismenorea and fetal distress

14) Confidence 0.68 Published 1995 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 7611820 Disease Relevance 0.20 Pain Relevance 0.10

Naloxone prevents interruption of parturition and increases plasma oxytocin following environmental disturbance in parturient sows.

Positive_regulation (increases) of oxytocin in plasma associated with narcan

15) Confidence 0.68 Published 1992 Journal Physiol. Behav. Section Title Doc Link 1484848 Disease Relevance 0.07 Pain Relevance 0.38

Our data also indicate that OT mRNA levels evaluated by in situ hybridization significantly increased within the hypothalamic paraventricular nucleus of WT animals after induced sodium ingestion, giving support to former evidence indicating an inhibitory role for central OT in the control of sodium appetite.

Positive_regulation (increased) of OT in nucleus

16) Confidence 0.67 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.32 Pain Relevance 0.20

ITN were also associated with increased oxytocin use and a trend toward more cesarean births.

Positive_regulation (increased) of oxytocin

17) Confidence 0.67 Published 2000 Journal J Fam Pract Section Body Doc Link 10923551 Disease Relevance 0 Pain Relevance 0

Intrathecal narcotics are associated with prolonged second-stage labor and increased oxytocin use.

Positive_regulation (increased) of oxytocin associated with intrathecal

18) Confidence 0.67 Published 2000 Journal J Fam Pract Section Title Doc Link 10923551 Disease Relevance 0 Pain Relevance 0.29

The increase in the oxytocin response in onapristone-treated animals was not associated with an increase in myometrial oxytocin receptor concentrations either during late pregnancy or before term.

Positive_regulation (increase) of oxytocin

19) Confidence 0.65 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1661070 Disease Relevance 0.09 Pain Relevance 0.17

Onapristone priming increased the ability of oxytocin to induce delivery during late pregnancy and before term by factors of greater than or equal to 30 and approximately 10, respectively.

Positive_regulation (increased) of oxytocin

20) Confidence 0.65 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1661070 Disease Relevance 0.09 Pain Relevance 0.17

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