INT93715

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 69
Total Number 71
Disease Relevance 36.05
Pain Relevance 11.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
macrophage 2
extracellular matrix 2
plasma 1
coronary sinus 1
fibroblasts 1
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1923 100.00 Very High Very High Very High
COX-2 inhibitor 46 99.84 Very High Very High Very High
Inflammation 539 99.70 Very High Very High Very High
methotrexate 14 99.70 Very High Very High Very High
rheumatoid arthritis 206 98.26 Very High Very High Very High
cytokine 275 97.22 Very High Very High Very High
sodium channel 15 97.20 Very High Very High Very High
Osteoarthritis 85 96.56 Very High Very High Very High
Arthritis 240 96.16 Very High Very High Very High
corticosteroid 8 94.28 High High
Disease Link Frequency Relevance Heat
Death 111 100.00 Very High Very High Very High
Cancer 1141 99.88 Very High Very High Very High
Skin Cancer 50 99.86 Very High Very High Very High
Urological Neuroanatomy 56 99.74 Very High Very High Very High
INFLAMMATION 595 99.70 Very High Very High Very High
Necrosis 80 99.60 Very High Very High Very High
Arthritis 270 99.48 Very High Very High Very High
Corneal Neovascularization 12 99.30 Very High Very High Very High
Breast Cancer 116 99.08 Very High Very High Very High
Prostate Cancer 249 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of human gingival gelatinases (MMP-2 and MMP-9) by metal salts.
Negative_regulation (Inhibition) of MMP-9
1) Confidence 0.55 Published 2000 Journal Dent Mater Section Title Doc Link 11203530 Disease Relevance 0.27 Pain Relevance 0.22
Inhibition of MMP-2 and MMP-9 activities was partly prevented by the addition of 1,10 phenanthroline, a divalent metal chelator, to the amalgam conditioned buffers.
Negative_regulation (Inhibition) of MMP-9
2) Confidence 0.55 Published 2001 Journal Biomaterials Section Abstract Doc Link 11426881 Disease Relevance 0.23 Pain Relevance 0.23
The proteolytic activities of MMP-2 and MMP-9 were strongly inhibited by dispersed phase amalgams conditioned buffers.
Negative_regulation (inhibited) of MMP-9
3) Confidence 0.55 Published 2001 Journal Biomaterials Section Abstract Doc Link 11426881 Disease Relevance 0.24 Pain Relevance 0.23
Taking into consideration that TIMP-2 functions predominantly as an MMP9 inhibitor (through its catalytic domain) and a proMMP2 activator (through its noncatalytic haemopexin domain), the presence of anti-TIMP-2 antibodies may favour accumulation of functional MMP2.
Negative_regulation (inhibitor) of MMP9
4) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.55 Pain Relevance 0.30
Further, transfection of promoter genes of MMPs and their transcription factors clearly exhibited that inhibition of MMP-2 and MMP-9 was due to down-regulation of transcription factor, NF-kappaB.
Negative_regulation (inhibition) of MMP-9
5) Confidence 0.49 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.48 Pain Relevance 0.20
Since MMPs involve in joint inflammation, it can be presumed that inhibition of MMP-2 and MMP-9 can be one of the mechanisms of SGlc to be an effective drug in relieving the symptoms of osteoarthritis.
Negative_regulation (inhibition) of MMP-9 in joint associated with inflammation, osteoarthritis and arthritis
6) Confidence 0.49 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.52 Pain Relevance 0.22
It also lowered down the activity of MMP-2 and MMP-9, and could reduce of MMP-2 secretion of cell lines.
Negative_regulation (lowered) of MMP-9
7) Confidence 0.46 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15803368 Disease Relevance 0.26 Pain Relevance 0
The use of an ELISA and zymography demonstrated that MMP-2 and MMP-9 enzyme activity were decreased in HT-29 cells by treatment with various concentration of 5-aminosalicylic acid.
Negative_regulation (decreased) of MMP-9 in HT-29
8) Confidence 0.42 Published 2009 Journal Dig Liver Dis Section Body Doc Link 18976971 Disease Relevance 0.14 Pain Relevance 0
These inhibitors did not appear to alter 15-PGDH mRNA levels but down-regulate matrix metalloproteinase-9 (MMP-9).
Negative_regulation (down-regulate) of matrix metalloproteinase-9 associated with metalloproteinase
9) Confidence 0.41 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.51 Pain Relevance 0.43
PC3/SiRNA clones also exhibited maximum decrease in MMP-9 activity.
Negative_regulation (decrease) of MMP-9
10) Confidence 0.38 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.28 Pain Relevance 0.03
MMP-9 activity is significantly reduced in PC3/OPN (RGA) (B, lanes 7–10) although these individual clones express maximum levels of mutated OPN as shown in Figure 1A (lane 5).
Negative_regulation (reduced) of MMP-9
11) Confidence 0.38 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.37 Pain Relevance 0.04
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Negative_regulation (inhibited) of MMP9 associated with metalloproteinase
12) Confidence 0.38 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.83 Pain Relevance 0.23
According to Sobrin et al, MMP-3 independently activated MMP-9 on the ocular surface, and doxycycline decreased MMP-9 activity in corneal epithelial cultures.8 Zylberberg et al found that both pro-MMP-2 and pro-MMP-9 were secreted by the lacrimal gland, and were likely up-regulated by estrogen.19 Kobayashi reported that leptomycin B reduced MMP-9 expression.4 During corneal wound healing, transforming growth factor-?
Negative_regulation (decreased) of MMP-9 in lacrimal gland associated with disorders of the lacrimal system and wound healing
13) Confidence 0.37 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915870 Disease Relevance 0.84 Pain Relevance 0.20
On the other hand, it is also possible that a prolonged exposure of cells to n-3 fatty acids is necessary for inhibition of AA-triggered MMP-9 activity [19].
Negative_regulation (inhibition) of MMP-9
14) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.07 Pain Relevance 0.03
This corresponded to a mean decrease in MMP-9 concentration of 25 %.
Negative_regulation (decrease) of MMP-9
15) Confidence 0.37 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0 Pain Relevance 0
Importantly, we showed that TIMP-2 antibodies purified from RA patients were functionally active, since they were able to neutralize TIMP-2-mediated inhibition of MMP9.
Negative_regulation (inhibition) of MMP9 associated with rheumatoid arthritis
16) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.77 Pain Relevance 0.28
Furthermore, flurbiprofen was shown to induce the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9.
Negative_regulation (inhibitor) of MMP-9 associated with metalloproteinase
17) Confidence 0.35 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.33 Pain Relevance 0.28
RESULTS: ZnSO4 was a strong inhibitor of MMP-2 (I50 = 15 microM) and MMP-9 (I50 = 40 microM), whereas CuSO4, HgSO4 and SnCl2 showed less efficient inhibition potential.
Negative_regulation (inhibitor) of MMP-9
18) Confidence 0.35 Published 2000 Journal Dent Mater Section Body Doc Link 11203530 Disease Relevance 0 Pain Relevance 0
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of MMP9 associated with methotrexate
19) Confidence 0.34 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.53 Pain Relevance 0.22
It also lowered down the activity of MMP-2 and MMP-9, and could reduce of MMP-2 secretion of cell lines.
Negative_regulation (lowered) of MMP-9
20) Confidence 0.33 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15803368 Disease Relevance 0.26 Pain Relevance 0

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