INT93717

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 85
Total Number 101
Disease Relevance 33.95
Pain Relevance 24.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
TMJ 6
chondrocytes 5
macrophage 5
endometrium 5
spinal cord neurons 3
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 1498 100.00 Very High Very High Very High
Snapping jaw 59 100.00 Very High Very High Very High
Pain 131 99.84 Very High Very High Very High
Spinal cord 285 99.82 Very High Very High Very High
nMDA receptor 548 99.68 Very High Very High Very High
spinal inflammation 34 99.28 Very High Very High Very High
cytokine 81 99.20 Very High Very High Very High
Osteoarthritis 482 98.96 Very High Very High Very High
dorsal root ganglion 115 98.76 Very High Very High Very High
Etanercept 34 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 166 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 59 100.00 Very High Very High Very High
Pain 126 99.84 Very High Very High Very High
Rotator Cuff Tears 360 99.48 Very High Very High Very High
Death 41 99.48 Very High Very High Very High
Ulcers 56 99.36 Very High Very High Very High
Low Back Pain 33 99.28 Very High Very High Very High
Necrosis 15 99.16 Very High Very High Very High
Apoptosis 36 99.04 Very High Very High Very High
Cancer 50 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Gene_expression (expression) of MMP-3 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.78 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.95 Pain Relevance 0.68
The results indicate that MMP9 and MMP3 were predominantly produced by disc cells, and these may be considered to play a pivotal role in ECM degradation during pathological conditions of the TMJ, such as IL-1-induced TMJ arthritis.
Gene_expression (produced) of MMP3 in TMJ associated with snapping jaw and arthritis
2) Confidence 0.68 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.49 Pain Relevance 0.63
The application of LPS to the pulp increased NOS activity, PGE(2), and MMP-3 production associated with iNOS overactivity.
Gene_expression (production) of MMP-3
3) Confidence 0.67 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.31
Moreover, PGE(2) and MMP-3 production were the result of cox-2 expression.
Gene_expression (production) of MMP-3
4) Confidence 0.67 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.32
Among the genes with changed expression levels, we focused on matrix metalloproteinase-3 (MMP-3, stromelysin-1) and CD163, a macrophage marker.
Gene_expression (expression) of MMP-3 in macrophage associated with metalloproteinase
5) Confidence 0.67 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.90 Pain Relevance 0.61
To analyse the cellular expression of MMP-3 we used an MMP-3-specific antibody for immunohistochemistry of cultured spinal cord neurons (Fig. 4).
Spec (analyse) Gene_expression (expression) of MMP-3 in spinal cord neurons associated with spinal cord
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.17
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Gene_expression (levels) of MMP-3 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
7) Confidence 0.60 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.95 Pain Relevance 0.67
PGE(2) and MMP-3 production were evaluated by an enzyme-linked immunosorbent assay (ELISA) and cyclooxygenase (cox-1 and cox-2) messenger RNA levels were measured using a reverse-transcriptase polymerase chain reaction by coamplification of target complementary DNA with a single set of primers.
Gene_expression (production) of MMP-3
8) Confidence 0.59 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.24 Pain Relevance 0.20
Pilocarpine (5 x 10(-11) mol/L to 5 x 10(-9) mol/L), acting on mAChRs, triggered a negative effect on NOS activity, PGE(2), and MMP-3 production.
Gene_expression (production) of MMP-3
9) Confidence 0.59 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.34
METHODS: MMP3 genotypes were examined in 229 pedigrees with AS, 131 sporadic AS cases and 87 Caucasian controls.
Spec (examined) Gene_expression (examined) of MMP3
10) Confidence 0.58 Published 2005 Journal Rheumatology (Oxford) Section Body Doc Link 15546966 Disease Relevance 0.10 Pain Relevance 0
In conclusion, our data are in agreement with the notion that cultured spinal cord neurons express MMP-3 which can be detected as proenzyme and as activated protein.


Gene_expression (express) of MMP-3 in spinal cord neurons associated with spinal cord
11) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.15
Consistent with the hypothesis that MMP-3 is involved in the cleavage of NR1 ectodomains we detected the activated forms of MMP-3 (45 and ?
Gene_expression (involved) of MMP-3 in cleavage
12) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
In control experiments we proved the activation of MMP-3 in the in vitro digestion assays by immunoblotting with an MMP-3-specific antibody, detecting the activated MMP-3 protein (44/45 kDa) (Fig. 3B).
Gene_expression (detecting) of MMP-3 protein
13) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.21
The latter finding indicates that MMP-3-dependent shedding of this signaling molecule is involved in regulating apoptotic cell death.
Gene_expression (shedding) of MMP-3-dependent in apoptotic cell associated with apoptosis and death
14) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0.69 Pain Relevance 0.18
Preabsorbtion of anti-MMP-3 antibody was done in 1?
Gene_expression (antibody) of MMP-3
15) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.05
Densitometry revealed that the level of the activated MMP-3 was slightly increased upon NMDA treatment (1.54±0.13 fold, mean±SEM; n?
Gene_expression (level) of MMP-3
16) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
As a result of immunohistochemical study, large ganglion neurons, but neither Schwann cells nor macrophages, predominantly expressed MMP-3.
Gene_expression (expressed) of MMP-3 in neurons associated with ganglion cysts
17) Confidence 0.53 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.94 Pain Relevance 0.67
The results showed decreased levels of MMP-3, sGAG and TNF-alpha compared with control levels.
Gene_expression (levels) of MMP-3
18) Confidence 0.51 Published 2008 Journal Phytother Res Section Abstract Doc Link 17726731 Disease Relevance 0.44 Pain Relevance 0.25
The expression of MMP-3 in the spinal cord culture was shown by immunoblotting and immunofluorescence microscopy.
Gene_expression (expression) of MMP-3 in spinal cord associated with spinal cord
19) Confidence 0.50 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.43
6 and matrix metalloproteinase (MMP3) gene expression.
Gene_expression (expression) of MMP3 associated with metalloproteinase
20) Confidence 0.49 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1560929 Disease Relevance 1.24 Pain Relevance 0.95

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